在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

USP37 Antibody, FITC conjugated

  • 中文名稱:
    USP37兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA801223LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) USP37 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    USP37
  • 別名:
    Deubiquitinating enzyme 3 antibody; Deubiquitinating enzyme 37 antibody; EC 3.1.2.15 antibody; KIAA1594 antibody; MGC117261 antibody; OTTHUMP00000164146 antibody; tmp_locus_50 antibody; Ubiquitin carboxyl-terminal hydrolase 37 antibody; Ubiquitin specific peptidase 37 antibody; Ubiquitin specific processing protease 37 antibody; Ubiquitin specific protease 37 antibody; Ubiquitin thioesterase 37 antibody; Ubiquitin thiolesterase 37 antibody; Ubiquitin-specific-processing protease 37 antibody; UBP37_HUMAN antibody; USP37 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 37 protein (671-797AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
  • 基因功能參考文獻:
    1. these findings reveal a role for REST-associated G9a and histone H3K9 methylation in the repression of USP37 expression in medulloblastoma. Reactivation of USP37 by G9a inhibition has the potential for therapeutic applications in REST-expressing medulloblastomas PMID: 28483947
    2. USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 in vivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin. PMID: 27296872
    3. USP37 associates with cohesin and contributes to sister chromatid resolution. Cohesion defects are rescued by expression of an RNAi-resistant USP37, but not the catalytically impaired USP37(C350A) mutant. PMID: 26299517
    4. USP37 is significantly upregulated in human lung cancer tissues, where its expression is positively correlated with c-Myc protein expression. PMID: 25284584
    5. These results suggested that the UIMs in USP37 contribute to the full enzymatic activity, but not ubiquitin chain substrate specificity, of USP37 possibly by holding the ubiquitin chain substrate in the proximity of the catalytic core. PMID: 24324262
    6. our findings of USP37-modulating PLZF/RARA stability and cell transformation suggest that USP37 is a potential therapeutic target for PLZF/RARA-associated APL PMID: 23208507
    7. USP37 links REST to the control of p27 stability and cell proliferation. PMID: 22665064
    8. Skp1-Cul1-F-box ubiquitin ligase (SCF(betaTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry PMID: 23027877
    9. The deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F factors in G1, peaked at G1/S, and was degraded in late mitosis. Phosphorylation of USP37 by CDK2 stimulated its full activity. PMID: 21596315

    顯示更多

    收起更多

  • 蛋白家族:
    Peptidase C19 family
  • 組織特異性:
    Expressed in brain and prostate.
  • 數據庫鏈接:

    HGNC: 20063

    KEGG: hsa:57695

    STRING: 9606.ENSP00000258399

    UniGene: Hs.166068



主站蜘蛛池模板: 久久国产一区二区三区| 久久国产超碰女女av| 欧美变态口味重另类在线视频| 欧美丰满熟妇xxxx性大屁股| 日本欧美久久久久免费播放网| 少妇一边呻吟一边说使劲| 国内午夜熟妇又乱又伦| 久久综合九色综合久99| 亚洲欧美综合区丁香五月小说| 水蜜桃精品一二三| 亚洲综合欧美在线一区在线播放| 东京热加勒比无码少妇| 国产又色又爽又黄又免费软件| 永久免费男同av无码入口| 18禁黄久久久aaa片| 亚洲自偷自拍熟女另类| 国产成人av免费观看| 国产精品久久久久久无码五月| 在线a久青草视频在线观看| 国产女人和拘做受视频免费| 天干夜啦天干天干国产免费| 一本一道色欲综合网| 久久久久久国产精品免费免费 | 无码高潮喷水在线观看| 久久这里只有精品首页| 久久久精品2020免费观看| 日韩av高潮喷水在线观看| 日本精品高清一区二区| 经典国产乱子伦精品视频| 国产又黄又潮娇喘视频在线观看 | 久久国产精品国产四虎90后| 九九视频免费精品视频| 亚洲欧美日韩国产成人精品影院| 在线综合亚洲欧美网站| 真人啪啪高潮喷水呻吟无遮挡| 色婷婷综合久久久中文字幕| 六月丁香婷婷色狠狠久久| 天天槽夜夜槽槽不停| 欧美黑人乱大交| 国产互换人妻hd| 加勒比中文字幕无码一区|