在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP28 Antibody

USP28 Antibody

  • 中文名稱：
    USP28兔多克隆抗體
  • 貨號：
    CSB-PA025718GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Deubiquitinating enzyme 28 antibody; KIAA1515 antibody; Ubiquitin carboxyl terminal hydrolase 28 antibody; Ubiquitin carboxyl-terminal hydrolase 28 antibody; ubiquitin carboxyl-terminal hydrolase 28 variant 1 antibody; Ubiquitin specific peptidase 28 antibody; Ubiquitin specific processing protease 28 antibody; Ubiquitin specific protease 28 antibody; Ubiquitin thioesterase 28 antibody; Ubiquitin thiolesterase 28 antibody; Ubiquitin-specific-processing protease 28 antibody; UBP28_HUMAN antibody; USP 28 antibody; USP28 antibody; USP28 protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human USP28
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.
  • 基因功能參考文獻(xiàn)：
    1. The authors identified 53BP1 and USP28 as essential components acting upstream of p53, evoking p21-dependent cell cycle arrest in response not only to centrosome loss, but also to other distinct defects causing prolonged mitosis. PMID: 27371829
    2. USP28 controls activation of both the TP53 branch and the GATA4/NFkB branch that controls the senescence-associated secretory phenotype (SASP) PMID: 29089421
    3. 53BP1-USP28 cooperation is essential for normal p53-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation. PMID: 27546791
    4. USP28-53BP1-p53-p21 signaling pathway is also required to arrest cell growth after a prolonged prometaphase. PMID: 27432896
    5. analysis of centrinone resistance identified a 53BP1-USP28 module as critical for communicating mitotic challenges to the p53 circuit and TRIM37 as an enforcer of the singularity of centrosome assembly. PMID: 27432897
    6. These results showed that USP28 is overexpressed in human glioblastomas and it contributes to glioma tumorigenicity. PMID: 26209720
    7. Data indicte that deubiquitinating enzyme USP28 was targeted by microRNA miR-4295. PMID: 25656529
    8. findings provide a first insight into understanding how the enzymatic activity of Usp28 is regulated by its non-catalytic UBR and endogenous ligands. PMID: 26268556
    9. identified Usp28 as a c-MYC target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC form a positive feedback loop that maintains high c-MYC protein levels in tumors PMID: 24960159
    10. USP28 has a chain preference activity for Lys(11), Lys(48), and Lys(63) diubiquitin linkages PMID: 25359778
    11. Usp28 expression was indentified as a independent predictors of survival (P = 0.001) and potentially valuable in prognostic evaluation of bladder cancer PMID: 24347490
    12. Study reveals a critical mechanism underlying the epigenetic regulation by USP28. PMID: 24075993
    13. USP28 is not a critical factor in double-strand break metabolism and is unlikely to be an attractive target for therapeutic intervention aimed at chemotherapy sensitization. PMID: 24687851
    14. USP28 gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species PMID: 23832602
    15. molecular cloning of USP28 & characterization of alternatively spliced products and tissue-specific isoforms PMID: 11597335
    16. Using a human cell line that faithfully recapitulated the Chk2-p53-PUMA pathway, we show that USP28 is required to stabilize Chk2 and 53BP1 in response to DNA damage. PMID: 16901786
    17. High expression levels of USP28 are found in colon and breast carcinomas, and stabilization of MYC by USP28 is essential for tumour-cell proliferation. PMID: 17558397

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus, nucleoplasm.
  • 蛋白家族：
    Peptidase C19 family, USP28 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12625

    OMIM: 610748

    KEGG: hsa:57646

    STRING: 9606.ENSP00000003302

    UniGene: Hs.503891



主站蜘蛛池模板： а天堂中文官网| 国产97色在线 | 国产| 亚洲自偷自拍另类11p| 无码国模产在线观看免费| 国产午夜成人免费看片| 国产精品无码一本二本三本色| 久久精品高清一区二区三区| 日产国产精品亚洲系列| 精品少妇人妻av无码久久| 国产麻传媒精品国产av| 丰满无码人妻熟妇无码区| 亚洲成在人线av品善网好看| 人人狠狠综合久久亚洲爱咲| 国产高清卡1卡2卡3麻豆| 日韩av高清无码| 人妻少妇精品视频二区| 欧美另类bbbxxxxx另类| 97人妻无码专区| 亚洲的天堂av无码| 性欧美熟妇videofreesex| 国产99久久久欧美黑人刘玥| 本道久久综合无码中文字幕| 亚洲欧美日本久久综合网站点击 | 精品综合久久久久久98| 中文字幕日韩人妻不卡一区| 欧美黑人异族videos| 欧美老熟妇喷水| 国产亚洲精品久久久网站好莱| 中文字幕日韩人妻在线视频| 人间精品视频在线播放| 成人a大片在线观看| 影音先锋人妻av中文字幕久久| 国产乱妇乱子在线播放视频| 精品一区二区三区免费毛片爱| 自拍偷自拍亚洲精品播放| 亚洲人成图片小说网站| 国产女人叫床高潮大片| 亚洲kkk4444在线观看| 精品久久久久久777米琪桃花| 人人妻人人爽人人澡欧美一区| 无码人妻精品一区二区三|