在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

USP26 Antibody

  • 中文名稱:
    USP26兔多克隆抗體
  • 貨號:
    CSB-PA874835ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA874835ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA874835ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) USP26 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    USP26
  • 別名:
    Deubiquitinating enzyme 26 antibody; MGC120066 antibody; MGC120067 antibody; MGC120068 antibody; Ubiquitin carboxyl terminal hydrolase 26 antibody; Ubiquitin carboxyl-terminal hydrolase 26 antibody; Ubiquitin specific peptidase 26 antibody; Ubiquitin specific processing protease 26 antibody; Ubiquitin specific protease 26 antibody; Ubiquitin thioesterase 26 antibody; Ubiquitin thiolesterase 26 antibody; Ubiquitin-specific-processing protease 26 antibody; UBP26_HUMAN antibody; USP 26 antibody; USP26 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 26 protein (664-913AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
  • 基因功能參考文獻:
    1. findings demonstrate TGF-beta enhances expression of USP26 and reinforces SMAD7 stability by limiting the ubiquitin-mediated turnover of SMAD7; clinically, loss of USP26 correlates with high TGF-beta activity and confers poor prognosis in glioblastoma; data identify USP26 as a novel negative regulator of the TGF-beta pathway and suggest that loss of USP26 expression may be an important factor in glioblastoma pathogenesis PMID: 28381482
    2. Data show that USP26 interacts with PRC1 components chromobox (CBX)-containing proteins CBX4 and CBX6. PMID: 28839133
    3. A novel USP26 variant p.R344W is associated with nonobstructive azoospermia probably through affecting androgen receptor function. PMID: 27089915
    4. The interaction between USP26 and Mdm2, and the subsequent deubiquitination of Mdm2, serves, most probably to regulate Mdm2. Future therapeutic modalities that interfere with the association between USP26 and Mdm2 will be used to destabilize the ligase in malignancies where it is upregulated. PMID: 27810359
    5. identification in a normozoospermic man of a nonsense mutation (c.882C>A) which causes the production of a truncated protein, suggests a marginal role of USP26 in male spermatogenesis PMID: 27726449
    6. Evidence from both enzymatic and meta-analyses does not support a direct association between USP26 variants and male infertility PMID: 25755145
    7. There is an association of alteration in USP26 with male infertility, especially in azoospermia and in the Asian population. [Meta-Analysis] PMID: 24875820
    8. there is a significant difference in USP26 gene expression between the obstructive azoospermia, complete maturation arrest samples and Sertoli Cell-Only Syndrome samples PMID: 23779098
    9. results indicated the variation of USP26 was not directly associated with human sperm count but suggested it might be a potential role in sperm motility PMID: 21147082
    10. The nucleotide polymorphisms of the Usp26 gene might be closely related with idiopathic male infertility, and exert a negative effect on the testis function. PMID: 22568204
    11. USP26 assembles with androgen receptors (AR)and other cofactors in subnuclear foci and serves to counteract hormone-induced AR ubiquitination, thereby contributing to the regulation of AR transcriptional activity. PMID: 20501646
    12. Alterations in the USP26 gene may be involved in male infertility or might increase the risk of male infertility. These patients showed 370-371insACA, 494T>C and 1423C>T causing T123-124ins, L165S and H475Y, respectively PMID: 15562280
    13. The USP26 gene may be of importance in male reproduction. Mutations in this gene may be associated with male infertility, and may negatively affect testicular function. PMID: 15970005
    14. USP26 haplotype is present in significant frequencies in sub-Saharan African and South and East Asian populations, including in individuals with known fertility. This indicates that the allele is not associated with infertility. PMID: 16888075
    15. Sequencing can confirm the presence of the three changes of the USP26 gene in patients of Caucasian origin with cryptozoospermia or oligozoospermia. PMID: 17121659
    16. The USP26 gene might be of importance in male reproduction. Mutations in this gene might be associated with male infertility, and might negatively affect testicular function. PMID: 17968467
    17. Mutations of the USP26 gene do not appear to be a common cause of idiopathic azoospermia or severe oligozoospermia. PMID: 18377898
    18. Mutation within the USP26 gene is associated with risk of inguinal hernia leading to impaired male fertility. PMID: 18927127
    19. Some USP26 alleles and haplotypes are associated with spermatogenic defect in the Han nationality in Taiwan PMID: 18958354

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Peptidase C19 family
  • 數據庫鏈接:

    HGNC: 13485

    OMIM: 300309

    KEGG: hsa:83844

    STRING: 9606.ENSP00000359869

    UniGene: Hs.333137



主站蜘蛛池模板: 五级黄高潮片90分钟视频| 性开放的欧美大片| 欧美疯狂做受xxxx高潮 | 日韩精品一区二区三区色欲av| 超清av在线播放不卡无码| 国产午夜亚洲精品区| 久久三级中文欧大战字幕| 亚洲综合另类小说专区| 亚洲综合色成在线播放| 国产猛男猛女超爽免费视频| 黑人好猛厉害爽受不了好大撑| 国产高清-国产av| 午夜亚洲国产理论片二级港台二级 | 中文字幕无码不卡一区二区三区| 日本xxxx色视频在线观看| 国产精品18久久久久久欧美| 上司人妻互换中文字幕| 毛片免费全部无码播放| 久久久国产99久久国产久麻豆 | 九九热爱视频精品视频| 国产午夜福利精品一区二区三区 | 国产精品aⅴ视频在线播放| 国产精品亚洲综合一区二区三区| 中文天堂在线www| 欧美亚洲综合成人专区| 蜜柚av久久久久久久| 欧美激情a∨在线视频播放| 丰满少妇作爱视频免费观看| 无码国产片观看| 亚洲精品乱码久久久久久中文字幕| 中国少妇无码专区| 免费国产乱理伦片在线观看| 四虎影视永久免费观看在线| 国产特级毛片aaaaaaa高清| 欧美变态另类xxxx| 免费观看男女性高视频| 日韩精品人成在线播放 | 粗大猛烈进出高潮视频| 国产精品自产拍在线观看| 国产高清无套内谢| 国产女厕所盗摄老师厕所嘘嘘|