在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

USP10 Antibody

  • 中文名稱:
    USP10兔多克隆抗體
  • 貨號:
    CSB-PA025696GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Deubiquitinating enzyme 10 antibody; KIAA0190 antibody; MGC124997 antibody; MGC2621 antibody; Ubiquitin carboxyl terminal hydrolase 10 antibody; Ubiquitin carboxyl-terminal hydrolase 10 antibody; Ubiquitin specific peptidase 10 antibody; Ubiquitin specific processing protease 10 antibody; Ubiquitin specific protease 10 antibody; Ubiquitin thioesterase 10 antibody; Ubiquitin thiolesterase 10 antibody; Ubiquitin-specific-processing protease 10 antibody; UBP10_HUMAN antibody; UBPO antibody; USP 10 antibody; USP10 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human USP10
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization.
  • 基因功能參考文獻:
    1. By using a genome wide siRNA screen for deubiquitinating enzymes, we identified USP10 as a deubiquitinase for Slug in cancer cells. USP10 interacts with Slug and mediates its degradation by the proteasome. Importantly, USP10 is concomitantly highly expressed with Slug in cancer biopsies. PMID: 29803676
    2. Loss of USP10 expression is associated with small intestinal adenocarcinoma. PMID: 30375264
    3. One of the USP10 targets is TP53. Wildtype TP53 is usually rescued from proteasomal degradation by USP10. As most KMT2A leukemias display wildtype p53 alleles, one might argue that the disruption of an USP10 allele can be classified as a pro-oncogenic event. PMID: 30107050
    4. Deubiquitylase USP10 interacts with RNF168 and TOP2alpha, and restrains ubiquitylation of TOP2alpha as well as its chromatin binding. PMID: 27558965
    5. USP10 directly interacted with and stabilized PTEN via deubiquitination. PMID: 28852924
    6. A controlling role for USP10 after wounding in determining myofibroblast development and activation of fibrotic TGFbeta signaling. PMID: 28851806
    7. Investigate the expression of USP10 in the human normal adrenal gland and various adrenal tumors. In adrenal tumors, detectable levels of USP10 protein were found in 100 % (30/30) adrenocortical adenomas, 88.89 % (8/9) adrenocortical carcinomas, and 10 % (2/20) pheochromocytomas. PMID: 26555087
    8. G3BP mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10. PMID: 27022092
    9. Data demonstrated that AMPK-USP10 form a positive feedforward loop that ensures amplification of AMPK activation in response to fluctuation of cellular energy status. PMID: 26876938
    10. miR-191 could promote pancreatic cancer progression through targeting USP10, implicating a novel mechanism for the tumorigenesis. PMID: 25168367
    11. USP10 deubiquitinates and stabilizes SIRT6. PMID: 24332849
    12. this study identified USP10, a carboxyl-terminal ubiquitin-processing protease, could interact with T-bet in the nucleus. PMID: 24845384
    13. USP10 is a host factor that inhibits stress-induced reactive oxygen species production and apoptosis in HTLV-1-infected T cells. PMID: 23775713
    14. a novel function for USP10 in facilitating the deubiquitination of CFTR in early endosomes, thereby enhancing the endocytic recycling and cell surface expression of CFTR. PMID: 20215869
    15. Findings reveal USP10 to be a novel regulator of p53, providing an alternative mechanism of p53 inhibition in cancers with wild-type p53. PMID: 20096447
    16. The data indicate that USP10 is a new cofactor that binds to the androgen receptor (AR) and stimulates the androgen response of target promoters. This finding underlines the role of the ubiquitin/proteasome system in modulating the AR function. PMID: 16368182
    17. RTQ-LDA and RTQ identified ubiquitin specific protease 10 as significantly over-expressed in dead-of-disease compared to long-term survival glioblastoma multiforme patients. PMID: 16773218
    18. USP10 has a role in facilitating the deubiquitination of CFTR in early endosomes and thereby enhancing the endocytic recycling of CFTR PMID: 19398555
    19. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10. G3BP does not appear to be a substrate of USP10; it rather inhibits its ability to disassemble ubiquitin chains. PMID: 11439350

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Early endosome.
  • 蛋白家族:
    Peptidase C19 family, USP10 subfamily
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 12608

    OMIM: 609818

    KEGG: hsa:9100

    STRING: 9606.ENSP00000219473

    UniGene: Hs.136778



主站蜘蛛池模板: 色综亚洲国产vv在线观看| 肉体裸交丰满丰满少妇在线观看| 久久精品国产99国产精2020丨| 亚洲日韩小电影在线观看| 国产成人无码激情视频| 久久久久免费看黄a片app| 亚洲成av人在线视| 亚洲午夜无码久久久久蜜臀av| 国产无遮挡免费真人视频在线观看| 亚洲国产欧美在线人成app| 国产在线视频一区二区三区| 亚州av综合色区无码一区| 色综合av综合无码综合网站| 亚洲精品久久7777777国产| 免费午夜男女高清视频| 久久久噜噜噜久久| 狠狠色综合网丁香五月| 三级久久试看3分钟| 成人无码视频在线观看网址| 色欲国产麻豆一精品一av一免费| 美女裸体自慰在线观看| 久久久青草青草免费看| 成人免费无码大片a毛片18| 两个黑人大战嫩白金发美女| 日本sm/羞辱/调教/捆绑视频| 国产精品一区二区香蕉| 免费永久在线观看黄网站| 久久久久高潮综合影院| 无码中文av有码中文av| 18禁美女裸体无遮挡网站| 少妇人妻大乳在线视频| 欧美人妻一区二区三区| 中国国产野外1级毛片视频| 日本xxxx丰满老妇| 插b内射18免费视频| 自拍日韩亚洲一区在线| 久久精品国产欧美日韩99热| 羞羞影院午夜男女爽爽免费| 搡8o老女人老妇人老熟| 级r片内射在线视频播放| 亚洲中文字幕永久在线不卡|