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USF2 Antibody, HRP conjugated

  • 中文名稱:
    USF2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA621888LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) USF2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    USF2
  • 別名:
    bHLHb12 antibody; Class B basic helix-loop-helix protein 12 antibody; FIP antibody; FOS interacting protein antibody; FOS-interacting protein antibody; Major late transcription factor 2 antibody; Upstream stimulatory factor 2 antibody; Upstream transcription factor 2 antibody; USF 2 antibody; Usf2 antibody; USF2_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Upstream stimulatory factor 2 protein (21-162AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
  • 基因功能參考文獻:
    1. TCF21 modulates Steroidogenic factor-1 and estrogen receptor beta expression through the recruitment of USF2 in endometriotic stromal cells. PMID: 30018006
    2. USF2, and its target gene PAI-1, regulate serum-stimulated keratinocyte growth, and likely the cadence of cell cycle progression in replicatively competent cells as part of the injury repair program. PMID: 24905330
    3. RNA Pol II on HIF1 or HIF2 target genes is primarily associated with HIF1alpha or HIF2alpha in a STAT3 or USF2 dependent manner PMID: 23991099
    4. USF2 functionally interacts with YY1 blocking its inhibitory activity, in favor of CEBPB transactivation. PMID: 23560079
    5. USF2 and hypoxia-inducible factor 2alpha (HIF2alpha) cooperatively activate HIF2 target genes during hypoxia. PMID: 22966206
    6. Bone morphogenetic proteins and ID1 exerted an anti-apoptotic effect in mesangial cells by inhibition of USF2 transcriptional activity. PMID: 21921026
    7. data established that high glucose stimulated USF2 expression in HK-2 cells, at least in part, through angiotensin II-AT1-dependent activation of CREB, which can contribute to diabetic tubulointerstitial fibrosis PMID: 20814220
    8. Usf2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells PMID: 20626032
    9. Ddata indicate that USF2 is one of the components of the FoxA1/androgen receptor transcriptional protein complex that contributes to the expression of androgen-regulated and prostate-specific genes. PMID: 19846536
    10. Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia. Impaired ERK1/2 signalling pathways were activated only by GM-CSF but not by Epo. PMID: 11583024
    11. defect in USF function may contribute to down-regulation of IGF2R expression in cancer cells. PMID: 12857727
    12. Cotransfection experiments demonstrated that overexpression of upstream stimulatory factor 2 increases cyclic GMP-dependent protein kinase I promoter activity in human vascular smooth muscle cells. PMID: 15741164
    13. USF1 and USF2 mRNA levels were reduced in non-small cell lung carcinoma; AP2-alpha levels were elevated; regression analysis demonstrated that reduced USF2 mRNA & increased AP2-alpha mRNA levels were predictive of downregulated PIGR mRNA expressions PMID: 15864740
    14. Data show that the elevated levels of USF2 in endometriosis account for, in part, the aberrant expression of SF-1 and its target gene StAR and aromatase. PMID: 18165439
    15. down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of chronic myeloid leukemia implicating a miRNA in its abnormal behavior PMID: 19074828
    16. decreased expression of the Hint1 gene through epigenetic silencing may play a role in enhancing the growth of a subset of human hepatoma by increasing the expression of genes controlled by the transcription factors beta-catenin, USF2, and NFkappaB PMID: 19089909

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  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 12594

    OMIM: 600390

    KEGG: hsa:7392

    STRING: 9606.ENSP00000222305

    UniGene: Hs.454534



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