在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UROS Antibody

UROS Antibody

  • 中文名稱：
    UROS兔多克隆抗體
  • 貨號：
    CSB-PA025679LA01HU
  • 規(guī)格：
    ￥440
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) UROS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UROS
  • 別名：
    congenital erythropoietic porphyria antibody; HEM4_HUMAN antibody; Hydroxymethylbilane hydrolyase [cyclizing] antibody; Hydroxymethylbilane hydrolyase antibody; OTTHUMP00000020709 antibody; OTTHUMP00000020710 antibody; UROIIIS antibody; Uroporphyrinogen III cosynthetase antibody; Uroporphyrinogen III synthase (congenital erythropoietic porphyria) antibody; Uroporphyrinogen III synthase antibody; Uroporphyrinogen-III cosynthase antibody; Uroporphyrinogen-III synthase antibody; UROS antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Uroporphyrinogen-III synthase protein (1-265AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，UROS Antibody (CSB-PA025679LA01HU)，的標記方式是Non-conjugated。對于UROS Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA025679LB01HU UROS Antibody, HRP conjugated ELISA
    FITC CSB-PA025679LC01HU UROS Antibody, FITC conjugated
    Biotin CSB-PA025679LD01HU UROS Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
  • 基因功能參考文獻：
    1. we show evidence that abnormal protein homeostasis is a prevalent mechanism responsible for UROS deficiency and that modulators of UROS proteolysis such as proteasome inhibitors or chemical chaperones may represent an attractive therapeutic option to reduce porphyrin accumulation and prevent skin photosensitivity in Congenital erythropoietic porphyria (CEP)patients when the genotype includes a missense variant. PMID: 28334762
    2. A, T to C change at nucleotide 34313, leading to a substitution of Leucine by Proline at codon 237, was observed in the homozygous state in a family with congenital erythropoietic porphyria. PMID: 22350154
    3. REVIEW: Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase and molecular basis of congenital erythropoietic porphyria PMID: 21570665
    4. Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R. PMID: 21343304
    5. Data show that branchpoint sequence (BPS)mutation reduced the wild-type transcript and UROS enzyme activity in CEP lymphoblasts to approximately 10% and 15% of normal, respectively. PMID: 19965637
    6. two novel misense mutations in the UROS gene. PMID: 17298225
    7. NMR analyses of URO-synthase titrated with competitive inhibitors N(D)-methyl-1-formylbilane or URO'gen III, revealed resonance perturbations of specific residues lining the cleft between 2 major domains of URO synthase that mapped enzyme's active site. PMID: 18004775
    8. The decrease in the expression of ubiquitous HMBS and UROS mRNAs under hypoxia is associated with accumulation of hypoxia-inducible factor 1alpha protein. PMID: 19021769
    9. UROS mutations related to erythropoietic porphyria identify a key helix for protein stability. PMID: 19099412

    顯示更多

    收起更多

  • 相關疾病：
    Congenital erythropoietic porphyria (CEP)
  • 蛋白家族：
    Uroporphyrinogen-III synthase family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12592

    OMIM: 263700

    KEGG: hsa:7390

    STRING: 9606.ENSP00000357775

    UniGene: Hs.501376



主站蜘蛛池模板： 成人精品一区日本无码网| 国产成年女人特黄特色毛片免| 欧美伊人色综合久久天天 | 国产精品久久久久不卡绿巨人| 久久久久无码精品国产人妻无码 | 色优久久久久综合网鬼色| 无码人妻少妇伦在线电影| 色综合欧美在线视频区| 香港经典a毛片免费观看hd| 九九热久久只有精品2| 少妇又色又紧又爽又刺激视频| 国产欧美日韩综合精品二区| 亚洲精品久久久一二三区 | 国产欧美成人xxx视频| 97久久超碰成人精品网站| 疯狂三人交性欧美| 天天爽夜夜爽人人爽一区二区| 毛片24种姿势无遮无拦| 国产情侣真实54分钟在线| 欧美老妇乱辈通奷| 国产精品h片在线播放| 国产人妻黑人一区二区三区 | 韩国三级中文字幕hd久久精品 | 亚洲a∨无码一区二区三区| 少妇脱了内裤让我添| 男女又色又爽又爽视频| 欧洲人免费视频网站在线| 亚洲国产日韩制服在线观看| 蜜桃臀无码内射一区二区三区 | 少妇人妻精品无码专区视频| 搡女人真爽免费视频大全| 欧美巨波霸乳影院| 久久九九精品国产av片国产| 国产偷国产偷亚洲清高app| 初尝人妻少妇中文字幕| 国内熟女啪啪自拍| 日韩~欧美一中文字幕| 少妇扒开腿让我爽了一夜| 伊人蕉久中文字幕无码专区| av激情亚洲男人的天堂| 亚洲精品网站在线观看你懂的|