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  4. UNC5D Antibody, FITC conjugated

UNC5D Antibody, FITC conjugated

  • 中文名稱：
    UNC5D兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA740925LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UNC5D Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UNC5D
  • 別名：
    UNC5D antibody; KIAA1777 antibody; UNC5H4 antibody; UNQ6012/PRO34692 antibody; Netrin receptor UNC5D antibody; Protein unc-5 homolog 4 antibody; Protein unc-5 homolog D antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Netrin receptor UNC5D protein (90-212AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell.
  • 基因功能參考文獻：
    1. The authors identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores. Within this locus, the joint effects of two independent single nucleotide polymorphisms had a p-value of 4.38 x 10(-9) for mental composite scores. PMID: 28754176
    2. Unc5D is thus a newly identified transcriptional target of proapoptotic p53 and may also act upstream of p53 to induce p53dependent apoptosis by phosphorylation at ser15. PMID: 24691657
    3. the dependence receptor UNC5H4 may act as a putative tumor suppressor in neuroblastoma. PMID: 24519068
    4. UNC5D is a functional tumor suppressor that is frequently downregulated in RCCs due to promoter hypermethylation and LOH. PMID: 23589179
    5. UNC5D forms a positive feedback loop with p53 and E2F1 to promote NGF dependence-mediated programmed cell death during neuroblastoma regression. PMID: 23778138
    6. UNC5H4 amplifies p53-dependent apoptotic response. PMID: 18402767

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Unc-5 family
  • 數據庫鏈接：

    HGNC: 18634

    OMIM: 616466

    KEGG: hsa:137970

    STRING: 9606.ENSP00000385143

    UniGene: Hs.238889



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