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  4. UNC5B Antibody

UNC5B Antibody

  • 中文名稱：
    UNC5B兔多克隆抗體
  • 貨號：
    CSB-PA025629LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA025629LA01HU diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA025629LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA025629LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UNC5B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UNC5B
  • 別名：
    6330415E02Rik antibody; A630020F16 antibody; D10Bwg0792e antibody; Netrin receptor UNC5B antibody; Netrin receptor UNC5B Precursor antibody; p53 regulated receptor for death and life antibody; p53 regulated receptor for death and life protein 1 antibody; p53-regulated receptor for death and life protein 1 antibody; p53RDL1 antibody; Protein unc-5 homolog 2 antibody; Protein unc-5 homolog B antibody; Protein XUNC 5 antibody; Transmembrane receptor Unc5H2 antibody; Unc 5 homolog 2 antibody; Unc 5 homolog B antibody; Unc 5 netrin receptor B antibody; UNC 5B antibody; Unc5 (C.elegans homolog) b antibody; Unc5b antibody; UNC5B_HUMAN antibody; UNC5H2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Netrin receptor UNC5B protein (404-517AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，UNC5B Antibody (CSB-PA025629LA01HU)，的標記方式是Non-conjugated。對于UNC5B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA025629LB01HU UNC5B Antibody, HRP conjugated ELISA
    FITC CSB-PA025629LC01HU UNC5B Antibody, FITC conjugated
    Biotin CSB-PA025629LD01HU UNC5B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • 基因功能參考文獻：
    1. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation. PMID: 27910960
    2. These findings point to a new important function of UNC5B and provide a potential basis for hASCs-mediated bone regeneration. PMID: 29158083
    3. Our results suggest that UNC5B overexpression inhibits the proliferation and migration of bladder cancer cells by inducing cell cycle arrest at G2/M phase. PMID: 27846823
    4. UNC5B expression is decreased in bladder cancer cells compared to normal bladder cell lines. PMID: 24528886
    5. Data indicate that dysregulation of expression of netrin-1 NTN1 in smooth muscle cell (SMC) and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques. PMID: 24122613
    6. unc5b expression is greater in adipose tissue of obese versus lean subjects. PMID: 24584118
    7. Higher netrin-1 and lower UNC5B expression in all prostate carcinoma cell lines indicated that netrin-1 and UNC5B could be used to predict metastasis. PMID: 23666553
    8. Low UNC5B expression was an independent risk factor for postoperative recurrence in patients with different stages and grades bladder cancer. PMID: 23055195
    9. UNC5B protein expressed in macrophages in hypoxic regions of atherosclerotic regions in human. PMID: 23599441
    10. UNC5B was downregulated in kidney carcinoma. PMID: 23526078
    11. Reducing Unc5b levels in Sip1 knockout slices and brains rescues cell migration in cortical interneurons. PMID: 23312517
    12. Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta PMID: 22252496
    13. The mRNA expression analysis using tissue samples revealed that UNC5B mRNA was down-expressed in about 20% of CRC patients, and the patients with low-UNC5B-expression tumors showed a significantly higher recurrence rate after curative surgery. PMID: 21922135
    14. Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B. PMID: 19570425
    15. Robo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors. PMID: 21238923
    16. The recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation. PMID: 21172653
    17. Down-regulation of UNC5b gene expression is related to angiogenesis of hepatocellular carcinoma. PMID: 20092749
    18. UNC5B receptor is localized to villous and extravillous cytotrophoblasts proximal to anchoring areas during the first trimester. PMID: 19826074
    19. Modulation of G(ialpha(2)) signaling by the axonal guidance of this protein PMID: 12359238
    20. In this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID: 19273616
    21. Stronger expression of UNC5B and UNC5C receptors in synovial fibroblasts might contribute to the disordered phenotype of rheumatoid arthritis and osteoarthritis. PMID: 19822088

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane raft.
  • 蛋白家族：
    Unc-5 family
  • 組織特異性：
    Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
  • 數據庫鏈接：

    HGNC: 12568

    OMIM: 607870

    KEGG: hsa:219699

    STRING: 9606.ENSP00000334329

    UniGene: Hs.522997



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