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  4. UNC50 Antibody, HRP conjugated

UNC50 Antibody, HRP conjugated

  • 中文名稱：
    UNC50兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA687496LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) UNC50 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UNC50
  • 別名：
    UNC50; UNCL; HSD-23; HSD23; Protein unc-50 homolog; Periodontal ligament-specific protein 22; PDLs22; Protein GMH1 homolog; hGMH1; Uncoordinated-like protein
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein unc-50 homolog protein (15-82AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the cell surface expression of neuronal nicotinic receptors. Binds RNA.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that biallelic mutation in the UNC50 gene underlies AMC through a probable loss of AChR expression at the neuromuscular junction which is essential for the cholinergic transmission during human muscle development. PMID: 29016857
    2. depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosomal degradation of STx2. UNC50 acted by recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi. PMID: 28883040
    3. UNC50 may plays some roles in HCC progression by affecting the EGFR pathway PMID: 25738771
    4. UNCL plays important roles in the development, differentiation, and maintenance of periodontal tissues and in the mechanotransduction of periodontal ligament fibroblasts. PMID: 17004066
  • 亞細(xì)胞定位：
    Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Unc-50 family
  • 組織特異性：
    Present in periodontal ligament fibroblasts (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16046

    OMIM: 617826

    KEGG: hsa:25972

    STRING: 9606.ENSP00000350409

    UniGene: Hs.13370



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