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UMPS Antibody, Biotin conjugated

  • 中文名稱:
    UMPS兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA728898LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UMPS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UMPS
  • 別名:
    ODC antibody; OMPdecase antibody; OPRT antibody; OPRTase antibody; Orotate phosphoribosyl transferase and orotidine 5' decarboxylase antibody; Orotate phosphoribosyltransferase antibody; Orotate phosphoribosyltransferase phosphoribosyltransferase antibody; Orotidine 5' phosphate decarboxylase antibody; Orotidine 5''-phosphate decarboxylase antibody; RP11-71H17.9 antibody; UMP synthase antibody; Umps antibody; UMPS_HUMAN antibody; Uridine 5' monophosphate synthase antibody; Uridine monophosphate synthetase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Uridine 5'-monophosphate synthase protein (314-444AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria. PMID: 28205048
    2. The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer PMID: 28347333
    3. OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes. PMID: 24158442
    4. The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer PMID: 22249354
    5. [review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity PMID: 19562503
    6. OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU. PMID: 22931617
    7. Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS. PMID: 21631301
    8. novel phosphoribosyltransferase transition states PMID: 20527751
    9. orotate phosphoribosyl transferase/DPD ratio has a relation to cancer staging and survival rate. PMID: 20647710
    10. Increased orotate phosphoribosyltransferase expression is associated with bladder cancers. PMID: 20112501
    11. expression of OPRT gene and the OPRT/dihydropyrimidine dehydrogenase ratio might be useful as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer PMID: 14562021
    12. thymidylate synthase and orotate phosphoribosyl transferase, but not dihydropyrimidine dehydrogenase, are more highly expressed in prostate cancer than in benign prostatic hyperplasia PMID: 15999119
    13. orotate phosphoribosyl transferase has a role in lymph node metastasis of gastric cancer PMID: 16142362
    14. The investigated SNPs of OPRT may have no major influence on 5-FU sensitivity. PMID: 16328050
    15. The OPRT Gly213Ala polymorphism seems to be a useful marker for predicting toxicity to bolus 5-FU chemotherapy. PMID: 16818689
    16. Overexpression of the OPRT gene plays an important role in the antiproliferative effect of 5-FU. PMID: 17237621
    17. High expression of OPRT is associated with the response to adjuvant chemotherapy in human pancreatic cancer PMID: 17549346
    18. data suggest that OPRT is involved in early events of pancreatic and gallbladder carcinogenesis and invasion of hepatocellular carcinomas PMID: 17607371
    19. decreased the sensitivities of the cultured tumor cells to 5-FU. These results suggest that the OPRT expression level in tumors is an additional determinant of the efficacy of 5-FU. PMID: 17854773
    20. OPRT activity levels in tumor tissue may be prognostic factor for survival in colorectal carcinoma with radical resection and 5-FU chemotherapy;postoperative survival was significantly better in patients with high OPRT activity PMID: 18597678
    21. determination of OPRT levels in gastric carcinoma tissue enables to predict the response to S-1-based neoadjuvant/adjuvant chemotherapy PMID: 18633253
    22. orotate phosphoribosyltransferase is involved in the invasion and metastasis of colorectal carcinoma PMID: 18949394
    23. decreased activity of OPRT plays an important role in the acquired resistance of gastric cancer cells towards 5-FU PMID: 19020740
    24. head & neck, gastric, colorectal, breast, lung & pancreatic cancer were examined; findings show mRNA expression & protein level of thymidylate synthase, dihydropyrimidine dehydrogenase & orotate phosphoribosyltransferase differed according to cancer type PMID: 19020767
    25. Immunohistochemical staining for Orotate phosphoribosyl transferase (OPRT)revealed strong expression of OPRT in prostate cancer cells. There was a significant correlation between OPRT mRNA expression levels and the tumor pathological grade PMID: 19082440
    26. High orotate phosphoribosyltransferase gene expression is associated with complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus PMID: 19307741

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  • 相關疾病:
    Orotic aciduria 1 (ORAC1)
  • 蛋白家族:
    Purine/pyrimidine phosphoribosyltransferase family; OMP decarboxylase family
  • 數據庫鏈接:

    HGNC: 12563

    OMIM: 258900

    KEGG: hsa:7372

    STRING: 9606.ENSP00000232607

    UniGene: Hs.2057



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