在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UGCG Antibody

UGCG Antibody

  • 中文名稱：
    UGCG兔多克隆抗體
  • 貨號：
    CSB-PA579990
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA579990(UGCG Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA579990(UGCG Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    UGCG
  • 別名：
    UGCG; Ceramide glucosyltransferase; GLCT-1; Glucosylceramide synthase; GCS; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human UGCG
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer. Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids.
  • 基因功能參考文獻：
    1. Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG) and multidrug resistance protein 1 (MDR1) overexpression and multidrug resistance development [Review]. PMID: 29409484
    2. Results suggest that the changes of DNA methylation status of the glucosylceramide synthase (GCS) promoter correlates with multidrug resistance in breast cancer. PMID: 27191984
    3. Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma. PMID: 26811497
    4. GCS was upregulated in colorectal carcinoma tissues compared to control tissues. PMID: 25535133
    5. We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women. PMID: 24960545
    6. Our data demonstrates a correlation between the expression of the GCS protein and ER-positive/HER-2 negative breast cancer PMID: 24456584
    7. our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD. PMID: 23913449
    8. GCS was upregulated in PTCs and might be an independent factor affecting prognosis. PMID: 24342307
    9. Glucosylceramide synthase mRNA were reduced by 62%. PMID: 24510559
    10. The results thus show that ARF6 regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels. PMID: 23555901
    11. DOX could modulate the expression of GCS through the Sp1 site of GCS promoter in ERalpha-positive breast cancer cells PMID: 23133636
    12. Ceramide glycosylation catalyzed by glucosylceramide synthase is important for cancer stem cells in drug resistance and tumorigenesis. PMID: 22936806
    13. Data indicate that a high expression of glucosylceramide synthase (GCS) seemed to be an indicator of poor prognosis. PMID: 20843709
    14. The authors conclude that hepatitis C virus proteins, especially NS5A and NS5B, have positive effects on the expression of human GlcT-1. PMID: 22270805
    15. GlcT-1 is up-regulated at the mRNA and protein levels during the course of U937 differentiation, resulting in increased amounts of GlcCer. PMID: 21558327
    16. Data show that nilotinib induces apoptosis through upregulating ceramide synthase genes and downregulating SK-1 in CML cells in addition to inhibition of BCR/ABL. PMID: 21756066
    17. GCS overexpression was highly associated with ER-positive and HER2-positive breast cancer with metastasis. PMID: 21617856
    18. Data show that GCS silencing increased the levels of phosphorylated p53 and p53-responsive genes. PMID: 21278235
    19. inhibition of the GCS gene affects the expression of MDR1 mRNA and P-gp function. PMID: 21380926
    20. GCSshRNA could efficiently suppress GCS and MDR1 expression in vitro and in vivo and these findings may be used as one of the methods to reverse multidrug resistance in breast cancer PMID: 19693666
    21. study demonstrates, for the first time, that GCS upregulates MDR1 expression modulating drug resistance of cancer. GSLs, in particular globo series GSLs mediate gene expression of MDR1 through cSrc and beta-catenin signaling pathway PMID: 20540746
    22. Positive correlation was detected between the expression of GCS and MDR1 mRNA in K562/A02 cells and MDR1 mRNA expression was down regulated after silencing the GCS gene expression. PMID: 20533270
    23. serve as negative regulator for ceramide PMID: 11915344
    24. Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. PMID: 12873973
    25. inhibition of glucosylceramide synthase led to increased CER galactosylation and protected U937 and HL-60 cells from DNR-induced apoptosis PMID: 14766899
    26. glucosylceramide synthase is not solely responsible for drug resistance in cancer cells PMID: 15263008
    27. p-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway GCS making a marked contribution to this resistance PMID: 15661399
    28. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. Transferase activity, transferring glycol groups PMID: 15747776
    29. the reticulon family member RTN-1C has been expressed and purified in Escherichia coli and its molecular structure has been analysed by fluorescence and Circular Dichroism spectroscopy PMID: 16500619
    30. it is suggested that a high level of GCS in leukemia is possible contributed to multidrug resistance of leukemia cells. PMID: 17709137
    31. Western analysis for glucosylceramide synthase showed a significant decrease in Alzheimer disease brain consistent with the hypothesis that enzyme dysfunction contributes to neuronal decay. PMID: 18155680
    32. High glucosylceramide synthase is associated with breast cancer. PMID: 18560890

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family
  • 組織特異性：
    Found in all tissues examined.
  • 數據庫鏈接：

    HGNC: 12524

    OMIM: 602874

    KEGG: hsa:7357

    STRING: 9606.ENSP00000363397

    UniGene: Hs.304249



主站蜘蛛池模板： 日韩av片无码一区二区三区| 国产av无码久久精品| 少妇内射兰兰久久| 欧美婷婷丁香五月社区| 久久久久久好爽爽久久| 天美传媒一区二区| 精品人妻伦九区久久aaa片69| 99久久精品午夜一区二区| 国产在线观看www污污污| 成人h动漫精品一区二区无码| 乱码丰满人妻一二三区| 99精品热在线在线观看视频 | 国产女人好紧好爽| 欧美一区二区三区视频在线观看| 日韩内射激情视频在线播放免费| 国产亚洲综合久久系列| 久久久精品国产免大香伊| 亚洲精品美女久久久久99| 伊人伊成久久人综合网996| 亚洲午夜精品久久久久久浪潮| 久久精品国产亚洲不av麻豆| 真人无码作爱免费视频| 老鸭窝视频在线观看| 日本免费一区二区三区日本| 国产午夜福利在线观看视频_| 影视先锋av资源噜噜| 精品国产一区二区三区色欲| 久久人午夜亚洲精品无码区| 亚洲愉拍99热成人精品热久久| 又粗又大又硬又长又爽| 亚洲熟妇久久国内精品| 最新777第四色米奇影视| 国产亚洲精品久久久久四川人| 欧美熟妇性开放| 国精品午夜福利视频导航| 欧美婷婷六月丁香综合色| 中文字幕乱妇无码av在线| 国产做a爰片久久毛片a片白丝| 自拍偷在线精品自拍偷免费 | 国产在线观看免费视频软件| 久久久久av无码免费网|