在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UFM1 Antibody, Biotin conjugated

  • 中文名稱:
    UFM1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA025560LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UFM1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UFM1
  • 別名:
    BM 002 antibody; BM002 antibody; C13orf20 antibody; Chromosome 13 open reading frame 20 antibody; Ubiquitin fold modifier 1 antibody; Ubiquitin-fold modifier 1 antibody; UFM1 antibody; UFM1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ubiquitin-fold modifier 1 protein (11-63AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription.
  • 基因功能參考文獻:
    1. UFM1 His 70 resembles UBA5 His336 and enters a negatively charged pocked on the other UFM1 molecule. PMID: 28360427
    2. Ufmylation may participate in regulation of the vascular smooth muscle cells phenotypic switch and endothelial cell injury, which may help in the understanding of vascular remodeling. PMID: 29461087
    3. These findings explicitly elucidate the role of UBA5 dimerization in UFM1 activation. PMID: 27653677
    4. This study, focused on identifying the mutated gene in patients with hypomyelination with atrophy of the basal ganglia and cerebellum without TUBB4A mutations, revealed a homozygous 3-bp deletion in the UFM1 promoter area, which perfectly segregates with the disease. PMID: 28931644
    5. Meta analysis identified a new gene, UFM1, that is associated with low von Willebrand factor levels. PMID: 26486471
    6. in the absence of UFSP2, a deconjugating enzyme for UFM1, ectopic expression of both UFL1 and UFBP1, which serve as the E3-ligase complex for the UFM1-system, dramatically increases UFM1-conjugate formation at the endoplasmic reticulum. PMID: 27926783
    7. data imply that the combination of a hypomorphic p.Ala371Thr variant in trans with a loss-of-function allele in UBA5 underlies a severe infantile-onset encephalopathy PMID: 27545674
    8. Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy PMID: 27545681
    9. results of an in vitro truncation assay suggest that Uba5 residues 57-363 comprise the minimal fragment required for the high-efficiency activation of Ufm1 PMID: 24915089
    10. ASC1 is a target for ufmylation and that UFBP1 is an essential component for ASC1 ufmylation. PMID: 25219498
    11. binding of ATP to Uba5 approximately Ufm1 thioester was required for efficient transfer of Ufm1 from Uba5 to Ufc1 via transthiolation. PMID: 24966333
    12. Thus, UfSP2 proteins have protease- and Ufm1-independent functions in GPCR biogenesis. PMID: 24603482
    13. the Ufm1 system plays a critical role in vesicle trafficking, and its inhibition may lead to protein overload in the ER and UPR activation. PMID: 23152784
    14. A novel type of E3 ligase for the Ufm1 conjugation system. PMID: 20018847
    15. The solution structure and dynamics of human Ufm1 (hsUfm1) by nuclear magnetic resonance spectroscopy was analysed. PMID: 16527251

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    UFM1 family
  • 數據庫鏈接:

    HGNC: 20597

    OMIM: 610553

    KEGG: hsa:51569

    STRING: 9606.ENSP00000239878

    UniGene: Hs.643655



主站蜘蛛池模板: 又黄又硬又湿又刺激视频免费 | 国产交换配偶在线视频| 激情av无码后入| 成人午夜福利视频后入| 中文字幕乱码亚洲无线三区| 乱人伦人妻中文字幕| 鲁丝片一区二区三区毛片| 国产99视频精品免费视频36| 爆乳护士一区二区三区在线播放| 国产精品av一区二区三区不卡蜜| 国产精品乱码高清在线观看| 一品二品三品中文字幕| 国产一区二区精品久久岳| 亚洲国产99精品国自产拍| 中国少妇偷人hd| 国产精品久久无码一区| 亚洲成av人片在线观看| 女人爽到喷水的视频大全| 国产成人片无码免费视频软件 | 亚洲精品无码不卡在线播放| 亚洲情综合五月天| 国产在线精品一区二区不卡麻豆| 国语精品福利自产拍在线观看| 丁香五月激情综合国产| 内谢少妇xxxxx8老少交| 亚洲综合色视频在线观看| 日韩精品一区二区三区在线观看| 色护士极品影院| 高清不卡毛片免费观看| 92午夜福利少妇系列| 国产3p露脸普通话对白| 午夜男女爽爽影院免费视频下载| 99国产精品久久久久久久成人| 黄网站色成年片在线观看| 国产福利酱国产一区二区| 中文字幕人妻丝袜二区| 中文字幕乱码中文乱码777 | 久久精品女人的天堂av| 无码人妻一区二区中文| 亚洲精品久久久久中文字幕二区 | 精品综合久久久久久888蜜芽|