在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UFD1 Antibody

  • 中文名稱:
    UFD1兔多克隆抗體
  • 貨號:
    CSB-PA842166ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: UFD1 antibody at 3.22µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Raji whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Lane 4: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 35, 39, 30 kDa
      Observed band size: 35 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA842166ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UFD1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    UB fusion protein 1 antibody; Ubiquitin fusion degradation 1 like (yeast) antibody; Ubiquitin fusion degradation 1 like antibody; Ubiquitin fusion degradation protein 1 homolog antibody; UFD1 antibody; UFD1_HUMAN antibody; UFD1L antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ubiquitin recognition factor in ER-associated degradation protein 1 protein (1-307AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I.
  • 基因功能參考文獻:
    1. We demonstrate that WT p97 can unfold proteins and that this activity is dependent on the p97 adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiquitination, with branched chains providing maximal stimulation. PMID: 28512218
    2. The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100. PMID: 26112410
    3. p97-Ufd1-Npl4 is an integral part of G2/M checkpoint signaling and thereby suppresses chromosome instability. PMID: 24429874
    4. Data indicate that the p97-UFD1L-NPL4 protein complex specifically associates with ubiquitinated IkappaBalpha via the interactions between p97 and the SCF(beta-TRCP) ubiquitin ligase. PMID: 24248593
    5. This study demonistrated that UFD1L may participate in the core cognitive deficits observed in schizophrenia. PMID: 23623450
    6. In coordination with the P97-UFD1-NPL4 complex (P97(UFD1/NPL4)), NUB1L promotes transfer of NEDD8 to proteasome for degradation. PMID: 24019527
    7. increased corpus callosum volume in children with 22q11DS is associated with UFD1L polymorphism. PMID: 22763378
    8. Data indicate that Npl4-Ufd1 heterodimer is required for VCP-FAF1 interaction. PMID: 23293021
    9. Data establish Cdc48/p97-Ufd1-Npl4 as a crucial negative regulator of Aurora B early in mitosis of human somatic cells and suggest that the activity of Aurora B on chromosomes needs to be restrained to ensure faithful chromosome segregation. PMID: 21486945
    10. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control PMID: 21571647
    11. This study suggested that AA genotype of UFD1L gene, which is involved in neurodevelopmental processes, may contribute to early-onset schizophrenia. Therefore, rs5992403 polymorphism may not be a risk factor for schizophrenia. PMID: 20471029
    12. Data suggest that the human cytomegalovirus dislocation reaction in US2 cells is independent of the p97 cofactor Ufd1-Npl4, and different retrotranslocation mechanisms can employ distinct p97 ATPase complexes to dislocate substrates. PMID: 20702414
    13. a functional analysis of its 5' regulatory region PMID: 11979512
    14. Ufd1l is localized around the nucleus and it does not interfere with Fas-and ceramide-mediated apoptosis. PMID: 12910480
    15. Ufd1-nuclear protein localization 4 is a negative regulator of retrotranslocation, delaying the retrotranslocation of endoplasmic reticulum-associated degradation substrates independently of its association with VCP PMID: 17331469
    16. This study identifies Ufd1 as a cofactor of gp78, reveals an unappreciated function of Ufd1 in the ubiquitination reaction during endoplasmic reticulum -associated degradation, and illustrates that Ufd1 plays a critical role in cholesterol metabolism. PMID: 17681147
    17. allelic associations of the UFD1L locus identified; 4-SNP haplotype analysis showed strong association with schizophrenia; possibility that a disease-resistant variant may be carried by two or more haplotypes due to frequent recombination during meiosis. PMID: 18270977
    18. This favors the model where the Ufd1-Npl4 dimer forms a regulatory gate at the exit from the retrotranslocone, rather than actively promoting retrotranslocation like the p97VCP ATPase. PMID: 18586029

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytosol.
  • 蛋白家族:
    UFD1 family
  • 組織特異性:
    Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
  • 數據庫鏈接:

    HGNC: 12520

    OMIM: 601754

    KEGG: hsa:7353

    STRING: 9606.ENSP00000263202

    UniGene: Hs.474213



主站蜘蛛池模板: 无码精品视频一区二区三区| 涩欲国产一区二区三区四区| 无码人妻丰满熟妇啪啪欧美 | 男女做爰真人视频直播| 欧美老妇牲交videos| 无码国产玉足脚交极品网站| 久久不见久久见免费影院国语| 人人妻人人澡人人爽不卡视频| 老子午夜精品无码| 国产自偷在线拍精品热| 国产97色在线 | 欧洲| 熟妇人妻系列aⅴ无码专区友真希 内射囯产旡码丰满少妇 | 免费午夜爽爽爽www视频十八禁| 亚洲人成网站日本片| 国产精华av午夜在线观看| 国产熟人av一二三区| 性欧美激情aa片在线播放| 伊人久久大香线蕉在观看| 精品亚洲国产成人av不卡| 日本va欧美va欧美va精品| 国产a√精品区二区三区四区 | 欧美老妇交乱视频在线观看| 亚洲欧美日韩综合久久久| 中国china体内裑精亚洲日本| 无码国内精品久久综合88| 国产97在线 | 亚洲| 手机看片国产av无码| 亚洲人成网站18禁止中文字幕| 人人插人人插人人爽| 国产午夜大地久久| 无码福利在线观看1000集| 亚洲熟妇无码另类久久久| 少妇无码一区二区二三区| 尤物国精品午夜福利视频| 鲁鲁鲁爽爽爽在线视频观看| 电影内射视频免费观看| 久久精品国产只有精品2020| 无码里番纯肉h在线网站| 狠狠色噜噜狠狠狠888米奇视频 | 午夜无码精品国产片| 精品1卡二卡三卡四卡老狼|