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  4. UBXN6 Antibody, Biotin conjugated

UBXN6 Antibody, Biotin conjugated

  • 中文名稱：
    UBXN6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA874859LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UBXN6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    UBX domain containing 1 antibody; UBX domain containing 2 antibody; UBX domain containing protein 1 antibody; UBX domain containing protein 6 antibody; UBX domain protein 6 antibody; UBX domain-containing protein 1 antibody; UBX domain-containing protein 6 antibody; UBXD1 antibody; UBXDC2 antibody; Ubxn6 antibody; UBXN6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human UBX domain-containing protein 6 protein (1-388AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
  • 基因功能參考文獻：
    1. These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin. PMID: 27913212
    2. UBXD1-N intercalates into the p97-ND1 interface, thereby modulating interdomain communication of p97 domains and its activity with relevance for disease pathogenesis PMID: 26475856
    3. Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1. PMID: 23335559
    4. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53. PMID: 22337587
    5. Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells. PMID: 21822278
    6. UBXD1 is a novel co-factor of the human p97 ATPase. PMID: 18656546
    7. An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified. PMID: 19174149
    8. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP. PMID: 19275885

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
  • 組織特異性：
    Enhanced expression in testis.
  • 數據庫鏈接：

    HGNC: 14928

    OMIM: 611946

    KEGG: hsa:80700

    STRING: 9606.ENSP00000301281

    UniGene: Hs.435255



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