在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UBXN6 Antibody, Biotin conjugated

UBXN6 Antibody, Biotin conjugated

  • 中文名稱：
    UBXN6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA874859LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UBXN6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    UBX domain containing 1 antibody; UBX domain containing 2 antibody; UBX domain containing protein 1 antibody; UBX domain containing protein 6 antibody; UBX domain protein 6 antibody; UBX domain-containing protein 1 antibody; UBX domain-containing protein 6 antibody; UBXD1 antibody; UBXDC2 antibody; Ubxn6 antibody; UBXN6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human UBX domain-containing protein 6 protein (1-388AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
  • 基因功能參考文獻：
    1. These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin. PMID: 27913212
    2. UBXD1-N intercalates into the p97-ND1 interface, thereby modulating interdomain communication of p97 domains and its activity with relevance for disease pathogenesis PMID: 26475856
    3. Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1. PMID: 23335559
    4. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53. PMID: 22337587
    5. Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells. PMID: 21822278
    6. UBXD1 is a novel co-factor of the human p97 ATPase. PMID: 18656546
    7. An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified. PMID: 19174149
    8. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP. PMID: 19275885

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
  • 組織特異性：
    Enhanced expression in testis.
  • 數據庫鏈接：

    HGNC: 14928

    OMIM: 611946

    KEGG: hsa:80700

    STRING: 9606.ENSP00000301281

    UniGene: Hs.435255



主站蜘蛛池模板： 大陆精大陆国产国语精品| 国产亚洲视频中文字幕97精品| av天堂永久资源网| 偷偷要色偷偷中文无码| 中文字幕av伊人av无码av狼人| 亚洲六月丁香六月婷婷| 中国孕妇变态孕交xxxx| 一本色道久久综合狠狠躁| 自拍偷在线精品自拍偷99| 国产高清在线精品一区小说| 亚洲欧洲成人a∨在线| 内射国产内射夫妻免费频道| 国产伦精品一区二区三区妓女下载| 中文无码伦av中文字幕在线| 中文字幕精品av乱码在线| 国产男女猛烈无遮挡免费网站| 色综合久久久无码中文字幕| 国产成人av区一区二区三| 丰满熟女高潮毛茸茸欧洲视频| 久久综合狠狠综合久久综合88| 内射少妇36p亚洲区| 成人毛片av免费| 久久伊人av综合影院 | 久久老子午夜精品无码怎么打| 精品人妻伦一二三区久久aaa片 | 最近中文字幕mv在线视频2018| 同性男男黄g片免费网站| 亚洲乱亚洲乱妇| 久久久精品456亚洲影院| 免费观看的av毛片的网站| 色护士极品影院| 日韩高清成片免费视频| 被拉到野外强要好爽黑人| 国模大胆一区二区三区| 久久精品国产第一区二区三区| 亚洲国产丝袜精品一区| 国产又黄又硬又粗| 在线成人a毛片免费播放| 曰本女人牲交高潮视频| 人妻体内射精一区二区三区| 欧美18精品久久久无码午夜福利|