在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UBR1 Antibody, HRP conjugated

UBR1 Antibody, HRP conjugated

  • 中文名稱：
    UBR1兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA812883LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) UBR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UBR1
  • 別名：
    E3 ubiquitin-protein ligase UBR1 antibody; JBS antibody; N-recognin-1 antibody; ubiquitin protein ligase E3 component n-recognin 1 antibody; Ubiquitin-protein ligase E3-alpha-1 antibody; Ubiquitin-protein ligase E3-alpha-I antibody; UBR1 antibody; UBR1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase UBR1 protein (722-862AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
  • 基因功能參考文獻(xiàn)：
    1. UBR1 mutations of single or multi-exon deletions or duplications account for a substantial proportion of Johanson-Blizzard syndrome. PMID: 29178640
    2. The frequency of any non-synonymous or synonymous variants was not different between the patients with chronic pancreatitis and controls PMID: 27397733
    3. Reduced UBR1 expression affects MGMT turnover and DNA repair in the smokers lungs. PMID: 26183928
    4. For all previously reported and novel UBR1 mutations together with their clinical data, a mutation database has been established at LOVD. PMID: 24599544
    5. Testing the fetus and the affected sibling with recurrent Johanson-Blizzard syndrome revealed a homozygous truncating mutation in UBR1. PMID: 21711208
    6. Results confirmed the relevance of specific missense UBR1 alleles to JBS, and suggested that a residual activity of a missense allele is causally associated with milder variants of JBS. PMID: 21931868
    7. Molecular studies revealed a novel homozygous nonsense mutation in exon 38 of the UBR1 gene, which confirmed the diagnosis of Johanson-Blizzard syndrome. PMID: 20556423
    8. Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1 PMID: 21041297
    9. Deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway. PMID: 16311597
    10. Sustained ERK5 activity and the E3 ligase UBR1 regulate the stability and subcellular localization of c-Fos. PMID: 17018293
    11. Thus we propose that autoISGylation of EFP negatively regulates its ISG15 E3 ligase activity for 14-3-3sigma. PMID: 17222803
    12. These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity. PMID: 17462600
    13. Thiazolidinediones modulate the expression of beta catenin and other cell cycle proteins by targeting UBR1 independently of PPARG. PMID: 17569795
    14. E3 ubiquitin ligase is an essential downstream component of the RAS signal transduction pathway. PMID: 18089810
    15. study reports on two apparently unrelated girls with Johanson-Blizzard syndrome, in both children caused by a homozygous IVS26+5G>A mutation in the UBR1 gene PMID: 19006206
    16. Case Report: Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing. PMID: 19058315

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Johanson-Blizzard syndrome (JBS)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    UBR1 family
  • 組織特異性：
    Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16808

    OMIM: 243800

    KEGG: hsa:197131

    STRING: 9606.ENSP00000290650

    UniGene: Hs.591121



主站蜘蛛池模板： 国产午夜精品一区理论片飘花| 麻豆精品导航| av在线播放无码线| 99久久综合狠狠综合久久| 国产精品刮毛| 爱色精品视频一区二区| 真实国产精品视频400部| av无码中出一区二区三区| 精品久久久无码人妻中文字幕豆芽 | 国产午夜激无码av毛片不卡| 国产92成人精品视频免费 | 老司机导航亚洲精品导航| 大香伊蕉在人线国产最新75| 亚洲男人的天堂在线va| 天堂在线.www天堂在线资源| 无码精品人妻一区二区三区影院 | 一本丁香综合久久久久不卡网站| 无码不卡中文字幕av| 国产亚洲精aa在线观看see| 欧美日韩精品一区二区在线观看 | 国模大胆一区二区三区| 中文字幕av久久激情亚洲精品| 国产69精品久久久久乱码| 国产乱子伦精品无码码专区| 18禁裸体动漫美女无遮挡网站| 久久综合丝袜日本网| 亚洲国产成人最新精品| 人妻av无码专区| 国产无套内射久久久国产| 伊人亚洲综合影院首页| 中美日韩毛片免费播放| 久久午夜无码鲁丝片| 亚洲国产精品久久久久秋霞影院| 欧美孕妇乳喷奶水在线观看| 99久久国产亚洲高清观看| 少妇又紧又深又湿又爽视频| 久久精品国产99国产精品亚洲 | 蜜臀avwww国产天堂| 野外少妇愉情中文字幕| 国产麻豆乱子伦午夜视频观看| 18禁无遮挡羞羞污污污污网站|