在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBQLN4 Antibody

  • 中文名稱:
    UBQLN4兔多克隆抗體
  • 貨號:
    CSB-PA040029
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    28S ribosomal protein S7 antibody; A1U antibody; A1Up antibody; AI663987 antibody; Ataxin 1 interacting ubiquitin like protein antibody; Ataxin 1 ubiquitin like interacting protein A1U antibody; Ataxin 1 ubiquitin like interacting protein antibody; Ataxin-1 ubiquitin-like-interacting protein A1U antibody; bMRP 27a antibody; bMRP27a antibody; C1orf6 antibody; CIP75 antibody; Connexin43 interacting protein of 75 kDa antibody; MRP S7 antibody; RGD1308273 antibody; S7mt antibody; UBIN antibody; Ubiquilin 4 antibody; Ubiquilin-4 antibody; UBQL4_HUMAN antibody; UBQLN4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human A1Up.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1. Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.
  • 基因功能參考文獻:
    1. UBQLN4 may induce cell cycle arrest and apoptosis via activation of the ERK pathway and upregulation of cyclin D1 in GES-1 cells. PMID: 29807370
    2. results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis. PMID: 29666234
    3. Here, the authors present a novel variant in UBQLN4 that is associated with ALS and show that its expression compromises motor axon morphogenesis in mouse motor neurons and in zebrafish. PMID: 28463112
    4. UBQLN4, APP, CTNNB1, SHBG, and COL1A1 might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition PMID: 28796060
    5. UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle. PMID: 27113755
    6. results suggested that CIP75 is essential for the interaction of Cx43 and the proteasome, but that alternate compensatory mechanisms exist to supplement the degradation normally facilitated by CIP75 PMID: 24256120
    7. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain. PMID: 23459205
    8. although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 and stimulation of Cx43 proteasomal degradation does not require the ubiquitination of Cx43. PMID: 20940304
    9. Co-immunoprecipitation confirmed the binding of small hydrophobic (SH) protein of mumps virus and ubiquilin 4 and demonstrates that a truncated protein fragment corresponding to amino acids 136-270 of ubiquilin 4 was sufficient for interaction. PMID: 20702650
    10. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43 PMID: 18079109

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Chromosome. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome.
  • 組織特異性:
    Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.
  • 數據庫鏈接:

    HGNC: 1237

    OMIM: 605440

    KEGG: hsa:56893

    STRING: 9606.ENSP00000357292

    UniGene: Hs.283739



主站蜘蛛池模板: 久久婷婷久久一区二区三区| 亚洲色成人网一二三区| 国产成人vr精品a视频| 国产成人乱色伦区| 亚洲国产品综合人成综合网站| 激情爆乳一区二区三区| 好湿好紧太硬了我太爽了视频| 大香伊蕉在人线国产网站首页| 亚洲欧洲日产国产 最新| 少妇人妻偷人精品无码视频新浪| 欧美一区二区三区成人久久片| 精品无码一区二区三区爱欲| 少妇mm被擦出白浆液视频| 亚洲va成无码人在线观看天堂| 波多野结衣在线观看一码| 久久99精品久久久久久齐齐| 精品av中文字幕在线毛片| 18禁午夜宅男成年网站| 久久天天躁狠狠躁夜夜网站| 国产乱人伦偷精品视频免观看| 国产片免费福利片永久| 国产亚洲精品美女久久久| 男人和女人高潮免费网站| 久久人人97超碰爱香蕉| 国产av无码精品色午夜| 两个黑人大战嫩白金发美女| 久久久无码人妻精品无码| 男女下面一进一出好爽视频| 99国精品午夜福利视频不卡| 天天躁夜夜躁狠狠眼泪| 五月丁香六月激情综合在线视频| 蜜桃av蜜臀av色欲av麻| 少妇中文字幕乱码亚洲影视 | 最新精品国偷自产在线美女足| 国产精自产拍久久久久久蜜| 亚洲卡1卡2卡新区网站| 无码人妻一区、二区、三区免费视频 | 亚洲第一无码精品立川理惠| 日本在线高清不卡免费播放| 国产片av片永久免费观看| √天堂中文官网8在线|