在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBQLN4 Antibody

  • 中文名稱:
    UBQLN4兔多克隆抗體
  • 貨號:
    CSB-PA040029
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    28S ribosomal protein S7 antibody; A1U antibody; A1Up antibody; AI663987 antibody; Ataxin 1 interacting ubiquitin like protein antibody; Ataxin 1 ubiquitin like interacting protein A1U antibody; Ataxin 1 ubiquitin like interacting protein antibody; Ataxin-1 ubiquitin-like-interacting protein A1U antibody; bMRP 27a antibody; bMRP27a antibody; C1orf6 antibody; CIP75 antibody; Connexin43 interacting protein of 75 kDa antibody; MRP S7 antibody; RGD1308273 antibody; S7mt antibody; UBIN antibody; Ubiquilin 4 antibody; Ubiquilin-4 antibody; UBQL4_HUMAN antibody; UBQLN4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human A1Up.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1. Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.
  • 基因功能參考文獻:
    1. UBQLN4 may induce cell cycle arrest and apoptosis via activation of the ERK pathway and upregulation of cyclin D1 in GES-1 cells. PMID: 29807370
    2. results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis. PMID: 29666234
    3. Here, the authors present a novel variant in UBQLN4 that is associated with ALS and show that its expression compromises motor axon morphogenesis in mouse motor neurons and in zebrafish. PMID: 28463112
    4. UBQLN4, APP, CTNNB1, SHBG, and COL1A1 might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition PMID: 28796060
    5. UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle. PMID: 27113755
    6. results suggested that CIP75 is essential for the interaction of Cx43 and the proteasome, but that alternate compensatory mechanisms exist to supplement the degradation normally facilitated by CIP75 PMID: 24256120
    7. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain. PMID: 23459205
    8. although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 and stimulation of Cx43 proteasomal degradation does not require the ubiquitination of Cx43. PMID: 20940304
    9. Co-immunoprecipitation confirmed the binding of small hydrophobic (SH) protein of mumps virus and ubiquilin 4 and demonstrates that a truncated protein fragment corresponding to amino acids 136-270 of ubiquilin 4 was sufficient for interaction. PMID: 20702650
    10. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43 PMID: 18079109

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Chromosome. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome.
  • 組織特異性:
    Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.
  • 數據庫鏈接:

    HGNC: 1237

    OMIM: 605440

    KEGG: hsa:56893

    STRING: 9606.ENSP00000357292

    UniGene: Hs.283739



主站蜘蛛池模板: 欧美成人精品午夜免费影视| 国产xxxx做受性欧美88| 妺妺跟我一起洗澡没忍住| 久久久亚洲欧洲日产国码二区 | 成人免费无码不卡毛片视频| 2021国产精品成人免费视频| 亚洲大尺度无码专区尤物| 国内精品免费久久久久电影院| 在线观看无码不卡av中文| 九九热久久只有精品2| av片在线播放| 久久午夜福利无码1000合集| 无码日韩精品一区二区人妻| 99精品国产一区二区三区| 夜夜躁狠狠躁日日躁202| 色琪琪av中文字幕一区二区| 好吊妞人成视频在线观看27du| 国产精品毛片无遮挡高清 | 国产熟女亚洲精品麻豆| 久久99精品国产自在现线小黄鸭 | 亚洲色欧美色2019在线| 中文字幕精品久久久久人妻红杏ⅰ | 精品国产乱码久久久久久免费| 午夜国产免费视频亚洲| 亚洲成a∧人片在线播放无码| 性一交一黄一片| 日韩人妻无码一区二区三区99| 久久青青草原国产最新片完整| 中文字幕av无码专区第一页| av老司机亚洲精品天堂| 狠狠躁夜夜躁人人躁婷婷| 国产成人人综合亚洲欧美丁香花| 国产一卡2卡3卡4卡网站精品| 自愉自愉产区二十四区| 综合无码精品人妻一区二区三区 | 人人澡人人曰人人摸看| 久久www色情成人免费观看| 少妇太爽了在线观看| 精品国产一区二区三区色欲| 免费无码午夜福利片69| 蜜臀av在线观看|