在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBE2T Antibody

  • 中文名稱:
    UBE2T兔多克隆抗體
  • 貨號:
    CSB-PA212556
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, Jurkat cells and K562 cells, using UBE2T antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UBE2T Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UBE2T
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human UBE2T.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
  • 基因功能參考文獻:
    1. Results show that UBE2T expression was increased in gastric tumors. Its suppression altered the expression of epithelial-mesenchymal transition factors and inhibited growth and colony formation, increased G2/M phase cell cycle arrest, and promoted apoptosis in gastric cancer cells. These findings provide evidence that UBE2T plays a critical role in gastric cancer. PMID: 28427240
    2. High UBE2T expression is associated with nasopharyngeal carcinoma. PMID: 26943030
    3. Collectively, our findings suggest UBE2T serves as a promising prognostic factor for HCC and functions as an oncogene. The newly identified miR-543/UBE2T/p53 axis may represent a new potential therapeutic target for HCC intervention. PMID: 28935368
    4. report the identification of a new allosteric pocket on Ube2T through a fragment screening using biophysical methods. Several fragments binding to this site inhibit ubiquitin conjugation in vitro PMID: 28437106
    5. Results showed that UBE2T was overexpressed in osteosarcoma tissues and cell lines. Moreover, UBE2T knockdown inhibited osteosarcoma cell proliferation, migration, and invasion. PMID: 27712593
    6. UBE2T plays an important role in the tumorigenesis of gastric cancer and could act as a potential independent prognostic factor for cancer therapy. PMID: 27020591
    7. Identify critical roles of UBE2T in prostate cancer development and progression. PMID: 26308072
    8. we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer susceptibility gene. PMID: 26085575
    9. UBE2T is the primary E2 of the FA pathway required for FANCD2 and FANCI activation. PMID: 26119737
    10. Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia PMID: 26046368
    11. hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway PMID: 21722982
    12. UBE2T is the ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway. PMID: 16916645
    13. UBE2T was significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype. PMID: 18667844
    14. This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination. PMID: 19111657
    15. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair. PMID: 19589784
    16. Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex. PMID: 19887602

    顯示更多

    收起更多

  • 相關疾病:
    Fanconi anemia complementation group T (FANCT)
  • 亞細胞定位:
    Nucleus. Note=Accumulates to chromatin.
  • 蛋白家族:
    Ubiquitin-conjugating enzyme family
  • 數據庫鏈接:

    HGNC: 25009

    OMIM: 610538

    KEGG: hsa:29089

    STRING: 9606.ENSP00000356243

    UniGene: Hs.5199



主站蜘蛛池模板: 欧美亚洲国产手机在线有码| 国产乱妇无乱码大黄aa片| 久久九九久精品国产| 99精品热在线在线观看视频| 亚洲精品无码aⅴ中文字幕蜜桃| 自慰无码一区二区三区 | 欧洲熟妇色 欧美| 少妇人妻上班偷人精品视频| 国产乱子伦一区二区三区四区五区| 亚洲另类激情综合偷自拍图| 中文字幕乱码人妻一区二区三区| 日产精品卡二卡三卡四卡乱码视频| 亚洲日韩a∨无码久| 日本va在线视频播放| 无码 人妻 在线 视频| 又色又爽又黄的吃奶视频免费观看| 国产明星裸体xxxx视频| 大胆欧美熟妇xx| 一本色道久久88综合日韩精品| 精品国产一区二区三区四区vr | 精品国产一区二区三区香蕉| 又爽又黄无遮拦成人网站| 中文字幕av无码人妻| 国产综合久久久久久鬼色| 国产精品久久无码一区二区三区网 | 丰满人妻翻云覆雨呻吟视频| 人妻丝袜中文无码av影音先锋专区| 在线偷着国产精选视频| 大战丰满无码人妻50p| 18禁高潮出水呻吟娇喘蜜芽| 亚洲精品国产嫩草在线观看东京热| 国产一区国产二区在线精品| 中文字幕有码无码人妻av蜜桃| 国产熟妇搡bbbb搡bbbb搡| 国产精品乱子伦xxxx裸| 国产精品视频免费一区二区| 疯狂做受xxxx高潮视频免费| 五月丁香综合缴情六月小说| 让少妇爽到高潮视频| 亚洲一卡二卡三卡四卡| 亚洲一区在线日韩在线秋葵|