在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UBE2K Antibody

UBE2K Antibody

  • 中文名稱：
    UBE2K兔多克隆抗體
  • 貨號：
    CSB-PA025460GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; Ubiquitin carrier protein antibody; Ubiquitin conjugating enzyme E2 25 kDa antibody; ubiquitin conjugating enzyme E2K antibody; ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody; Ubiquitin protein ligase antibody; Ubiquitin-conjugating enzyme E2 K antibody; Ubiquitin-conjugating enzyme E2(25K) antibody; Ubiquitin-conjugating enzyme E2-25 kDa antibody; Ubiquitin-conjugating enzyme E2-25K antibody; Ubiquitin-protein ligase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UBE2K
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
  • 基因功能參考文獻：
    1. The crystal structure of a Ube2K~ubiquitin conjugate has been described, and it was shown that even though it is monomeric, Ube2K can synthesize Lys48-linked ubiquitin chains. PMID: 26592444
    2. Hip2, a ubiquitin-conjugating enzyme, can overcome radiation-induced G2/M cell cycle arrest and trigger the entry into mitosis. PMID: 23933584
    3. An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin formation by the human ubiquitin-conjugating enzyme E2-25K. PMID: 22164771
    4. one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin chain synthesis, possibly through increased binding to the ubiquitinated substrate. PMID: 21281599
    5. Results suggest that the interaction between E2-25K and UBB(+1) is critical for the synthesis and accumulation of UBB(+1)-anchored polyubiquitin, which results in proteasomal inhibition and neuronal cell death. PMID: 20826778
    6. This study suggests that Hip2 might be involved in the regulation of Smac-mediated apoptosis. PMID: 20537984
    7. Results suggest that in permeabilized, US11-expressing cells polyubiquitination of the MHC class I heavy chain substrate can be catalyzed by E2-25K. PMID: 16868077
    8. E2-25K is involved in aggregate formation of expanded polyglutamine proteins and polyglutamine-induced cell death. PMID: 17092742

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 組織特異性：
    Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest leve
  • 數據庫鏈接：

    HGNC: 4914

    OMIM: 602846

    KEGG: hsa:3093

    STRING: 9606.ENSP00000261427

    UniGene: Hs.50308



主站蜘蛛池模板： 亚洲中文字幕永久在线全国 | 成熟妇人a片免费看网站| 蜜桃视频一区二区在线观看| 亚洲欧美精品suv| 无码人妻巨屁股系列| 精品久久久无码人妻中文字幕豆芽 | 久久丫精品系列| 老太脱裤让老头玩ⅹxxxx| 国产肉体ⅹxxx137大胆| 猫咪www免费人成网站无码| 人妻天天爽夜夜爽精品视频 | 69风韵老熟女口爆吞精| 欧美在线观看免费专区| 国产美女裸体无遮挡免费视频| 色两性网欧美| 天天躁日日躁狠狠躁2018| 人人澡人人妻人人爽人人蜜桃麻豆| 亚洲国产成人一区二区三区| 无遮挡裸体免费视频尤物| 色偷偷噜噜噜亚洲男人| 麻豆精产一二三产区| av不卡国产在线观看| 久久人妻少妇嫩草av| 国模叶桐尿喷337p人体| 影音先锋人妻av中文字幕久久 | 影视先锋av资源噜噜| 少妇高潮喷潮久久久影院| 香蕉精品亚洲二区在线观看| 少妇高潮惨叫久久久久电影| 国产天堂亚洲国产碰碰| 亚洲人成电影在线播放| 久久久www成人免费看片| 无码加勒比一区二区三区四区| 国产又黄又猛又粗又爽的a片动漫 成年女性特黄午夜视频免费看 | 色欲久久久中文字幕综合网| 色一情一乱一伦一区二区三区日本| 亚洲熟女乱综合一区二区在线| 少妇无码精油按摩专区| 无码成人精品区在线观看| 欧美在线看片a免费观看| 日韩一卡二卡三卡四卡免费观在线|