在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBE2D1 Antibody

  • 中文名稱:
    UBE2D1兔多克隆抗體
  • 貨號:
    CSB-PA025443GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    E2(17)KB1 antibody; SFT antibody; Stimulator of Fe transport antibody; UB2D1_HUMAN antibody; UBC 4/5 antibody; UBC4/5 antibody; UBC4/5 homolog antibody; UBC4/5, S. cerevisiae, homolog of antibody; UBCH 5 antibody; UBCH 5A antibody; UbcH5 antibody; UBCH5A antibody; Ube2d1 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein D1 antibody; Ubiquitin conjugating enzyme E2 17 kDa 1 antibody; Ubiquitin conjugating enzyme E2 D1 antibody; Ubiquitin conjugating enzyme E2D 1 (UBC4/5 homolog yeast) antibody; Ubiquitin conjugating enzyme E2D 1 antibody; Ubiquitin conjugating enzyme UBCH5A antibody; Ubiquitin protein ligase D1 antibody; Ubiquitin-conjugating enzyme E2 D1 antibody; Ubiquitin-conjugating enzyme E2(17)KB 1 antibody; Ubiquitin-conjugating enzyme E2-17 kDa 1 antibody; Ubiquitin-protein ligase D1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human UBE2D1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
  • 基因功能參考文獻:
    1. The anaphase-promoting complex/cyclosome C activity in human cells is tuned by the combinatorial use of three E2 ubiquitin-conjugating enzymes, namely UBE2C, UBE2S, and UBE2D. PMID: 26904940
    2. Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual. PMID: 26502057
    3. The Asp17 mutation in MDM2 stimulated its discharge of the UBCH5a-ubiquitin thioester adduct. PMID: 25543083
    4. The SMURF2:UBCH5 complex is critical in maintaining KRAS protein stability. PMID: 24709419
    5. Biochemical characterization of recombinant UBTD1 and UBE2D demonstrated that the two proteins form a stable, stoichiometric complex that can be purified to near homogeneity. PMID: 24211586
    6. crystal structure of the dimeric RING domain of rat RNF4 in complex with E2 (UbcH5A) linked by an isopeptide bond to ubiquitin PMID: 22842904
    7. These data demonstrate that the ability of ICP0 to interact with cellular E2 ubiquitin-conjugating enzyme UBE2D1 is fundamentally important for its biological functions during HSV-1 infection. PMID: 22438555
    8. identify the IDOL-UBE2D complex as an important determinant of LDLR activity, and provide insight into molecular mechanisms underlying the regulation of cholesterol uptake PMID: 21685362
    9. This structure reveals an interaction between the ubiquitin surface flanking K11 and residues adjacent to the E2 catalytic cysteine and suggests a possible role for this surface in formation of K11 linkages. PMID: 21396940
    10. The authors demonstrate that c-IAP1 and UbcH5 family promote K11-linked polyubiquitination of receptor-interacting protein 1 (RIP1) in vitro and in vivo. PMID: 21113135
    11. Whereas UbcH5(A, B and C) is highly efficient in converting IkBa into monoubiquitinated forms, Cdc34 drives ubiquitin (Ub)-Ub conjugation PMID: 20347421
    12. conformational changes in CHIP upon binding of Hsp70, Hsp90, and their respective C-terminal EEVD peptides, and in complex with the different E2 ubiquitin-conjugating enzymes UbcH5a and Ubc13 PMID: 20146531
    13. UbcH5A is up-regulated in the liver of iron-overloaded patients with hereditary hemochromatosis, but in vitro studies failed to show regulation in response to iron loading or chelation. Earlier in vivo mRNA expression data for SFT might be UbcH5A. PMID: 12480712
    14. comparison of the regional distribution of SFT/UbcH5A and DMT1 mRNA in the adult brain PMID: 15139022
    15. Ro52 has both cytoplasmic and nuclear substrates, and mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus. PMID: 18845142
    16. Catalytically active Ubc5 is required for IRF3 activation by viral infection. PMID: 19854139

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Ubiquitin-conjugating enzyme family
  • 組織特異性:
    Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.
  • 數據庫鏈接:

    HGNC: 12474

    OMIM: 602961

    KEGG: hsa:7321

    STRING: 9606.ENSP00000363019

    UniGene: Hs.129683



主站蜘蛛池模板: 麻豆一区二区在我观看| 乱码精品一区二区三区| 无码一区二区三区av在线播放| 精品欧美一区二区三区久久久 | 天天看片天天av免费观看| 中文字字幕在线精品乱码 | 夜夜高潮夜夜爽高清完整版1 | 国产精品亚洲一区二区z| 无码人妻一区二区三区线| 国产无遮挡又黄又爽免费网站| 色综合久久久久综合99| 亚洲欧美国产成人综合欲网| 欧美人与善在线com| 337p日本欧洲亚洲大胆在线| 国产精品18久久久久久麻辣| 国产午夜精品久久精品电影 | 国产欧美日韩综合精品一区二区| 未满十八18禁止免费无码网站| 婷婷五月综合丁香在线 | 国产人成高清在线视频99最全资源 | 亚洲精品无码av中文字幕电影网站 | 男女啪啪抽搐高潮动态图| 无码一区二区三区久久精品| 国产精品v欧美精品∨日韩| 亚洲精品人成网线在线播放va| 52综合精品国产二区无码| 日日碰狠狠躁久久躁| 国产成人综合色在线观看网站| 国产v精品成人免费视频| 午夜三级a三级三点在线观看 | 99久热re在线精品视频| 国产成人一区二区三区免费| 久久久亚洲欧洲日产国码是av| 久久精品农村毛片| 成人a毛片视频免费看| av午夜福利一片免费看久久| 奇米影视777四色狠狠| 国产成 人 综合 亚洲网站| 色 综合 欧美 亚洲 国产| 无码欧精品亚洲日韩一区 | 成人影片麻豆国产影片免费观看 |