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  4. UBA7 Antibody

UBA7 Antibody

  • 中文名稱：
    UBA7兔多克隆抗體
  • 貨號(hào)：
    CSB-PA025421GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    D8 antibody; MGC12713 antibody; UBA1, ubiquitin activating enzyme E1 homolog B antibody; UBA1B antibody; UBA7 antibody; UBA7, ubiquitin activating enzyme E1 antibody; UBA7_HUMAN antibody; Ube 1L antibody; UBE 2 antibody; UBE1L antibody; UBE2 antibody; Ubiquitin activating enzyme 2 antibody; Ubiquitin activating enzyme E1 homolog antibody; Ubiquitin Activating Enzyme E1 Like antibody; Ubiquitin activating enzyme E1 related protein antibody; Ubiquitin-activating enzyme 7 antibody; Ubiquitin-activating enzyme E1 homolog antibody; ubiquitin-activating enzyme-2 antibody; ubiquitin-like modifier activating enzyme 7 antibody; Ubiquitin-like modifier-activating enzyme 7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human UBA7
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
  • 基因功能參考文獻(xiàn)：
    1. RNF170, an endoplasmic reticulum (ER)-associated ubiquitin E3 ligase, interacted with pUL50 and promoted pUL50-mediated UBE1L degradation via ubiquitination. PMID: 29743376
    2. the cellular effects of progerin expression in Hutchinson-Gilford progeria syndrome are transduced, at least in part, through reduced function of the Ran GTPase and E2 SUMOylation pathways. PMID: 21670151
    3. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20601676
    4. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia PMID: 11891284
    5. RA treatment of APL and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 as well as intracellular ISG15 conjugates. A physical association was found between UBE1L and ISG15 in vivo. PMID: 14976209
    6. Ube1L was required for transfer of ISG15 to UbcH8 and for binding of Ube1L to UbcH8 PMID: 18583345
    7. UBE1L-ISG15 preferentially inhibits cyclin D1 in lung cancer PMID: 19074853

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  • 蛋白家族：
    Ubiquitin-activating E1 family
  • 組織特異性：
    Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12471

    OMIM: 191325

    KEGG: hsa:7318

    STRING: 9606.ENSP00000333266

    UniGene: Hs.16695



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