在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Trem2 Antibody, HRP conjugated

  • 中文名稱:
    Trem2兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA024405LB01MO
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Mus musculus (Mouse) Trem2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Trem2 antibody; Trem2a antibody; Trem2b antibody; Trem2c antibody; Triggering receptor expressed on myeloid cells 2 antibody; TREM-2 antibody; Triggering receptor expressed on monocytes 2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Triggering receptor expressed on myeloid cells 2 protein (19-171AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade. Required for microglial phagocytosis of apoptotic neurons. Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain. Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide. It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB. During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling. Plays a role in microglial MTOR activation and metabolism. Regulates age-related changes in microglial numbers. Triggers activation of the immune responses in macrophages and dendritic cells. Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages. In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival. Involved in the positive regulation of osteoclast differentiation.
  • 基因功能參考文獻(xiàn):
    1. The present study provide novel evidence that overexpression of TREM2 protects against MPTP-induced PD progression via modulation of microglial function through inhibiting TRAF6/TLR4-mediated activation of the MAPK and NF-kappaB signaling pathways. PMID: 29407460
    2. Our data establish a critical link between oAbeta1-42, a major pathological component of Alzheimer's disease and TREM2 PMID: 29587871
    3. These data suggest that the Alzheimer's disease-associated TREM2 R47H variant increases risk for Alzheimer's disease by conferring a loss of TREM2 function and enhancing neuritic dystrophy around plaques. PMID: 29859094
    4. Data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function. PMID: 29611543
    5. whereas complete TREM2 deficiency protected against tau-mediated microglial activation and atrophy, TREM2 haploinsufficiency elevated expression of proinflammatory markers and exacerbated atrophy at a late stage of disease. The differential effects of partial and complete loss of TREM2 on microglial function and tau pathology PMID: 30232263
    6. TREM2 plays a crucial role in altering the proinflammatory M1 microglia to M2 phenotype and has beneficial effects in the immune pathogenesis of Parkinson's disease. PMID: 29621548
    7. Overexpression of TREM2 downregulated the levels of IL-1beta, ameliorated T396 expression, inhibited the activity of GSK-3beta, and improved sickness behavior. Increased Arg1 expression and a high level of synaptophysin were also observed in the transgenic mice following TREM2 overexpression. PMID: 29689568
    8. These studies of the role of TREM2 in neuroinflammation and neurodegeneration suggest that impairing microglial TREM2 signaling reduces pure tauopathy. PMID: 29073081
    9. This article suggests a potential explanation of why TREM2-deficient microglia are unable to respond to neurotoxic plaques in the Alzheimer's disease brain and highlight a further need to understand microglial biology. PMID: 28978423
    10. TREM2 protects against cerebral ischemia/reperfusion injury through the aspect of post-ischemic inflammatory response and neuronal apoptosis. PMID: 28592261
    11. Results suggest that TREM2 plays a critical role in inflammation and neuronal cell survival and in neurogenesis. Study showed that TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma via radial glial cells. TREM2 protein is essential for neuroplasticity and myelination. A lack of TREM2 protein may accelerate aging. PMID: 27662313
    12. TREM2 deficiency influences both acute and chronic responses to traumatic brain injury, with altered macrophage response early on and improved functional outcome at later time points. PMID: 26976047
    13. A central role of TREM2 is in the regulation of microglia response to acute neurotoxic insults. PMID: 28189343
    14. Loss of TREM2 reduces the ability of microglia to engulf amyloid beta-peptide. PMID: 27402340
    15. TREM2 and TREML2 play opposite roles in microglia activation. PMID: 27143430
    16. Our study suggests that Vps35/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease. PMID: 27717139
    17. sTREM2 plays a crucial role in regulating microglial cell survival and inflammatory responses. PMID: 28209725
    18. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism. PMID: 28802038
    19. This study demonstrate a critical role of TREM2-mediated Wnt/beta-catenin pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival. PMID: 28077724
    20. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia. PMID: 28398927
    21. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation PMID: 27196974
    22. TREM2 deficiency has opposing effects on Alzheimer's disease-related pathologies at early and late stages of disease progression. PMID: 28100745
    23. TREM2 protects from Alzheimer's disease by enabling microglia to surround and alter Abeta plaque structure, thereby limiting neuritic damage. PMID: 27091843
    24. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 and DAP12, both of which are expressed by microglia and have bee PMID: 27798193
    25. The authors demonstrate that a TREM2 loss-of-function mutation causes brain-wide metabolic alterations pointing toward a possible function of microglia in regulating brain glucose metabolism. PMID: 28559417
    26. flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants PMID: 28490631
    27. Study found that TREM2 was upregulated in the brain of P301S mice, an animal model of tau pathology, during disease progression and showed that TREM2 overexpression rescued spatial cognitive impairments and ameliorated neuropathologies including neuronal and synaptic loss as well as tau hyperphosphorylation. PMID: 26802771
    28. This study showed that TREM-2 deficiency restricts the inflammatory response, thereby decreasing organ damage and mortality. PMID: 27253382
    29. TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology. PMID: 26364736
    30. TREM2 is involved in prion-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion infections. PMID: 25816748
    31. These findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages. PMID: 25563793
    32. TREM-1/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role. PMID: 25860078
    33. These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage PMID: 25631124
    34. TREM-2 has a protective effect on inflammatory response of endotoxin-induced acute lung injury in mice. PMID: 24916365
    35. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses. PMID: 25957402
    36. Corpus callosum microglia normally expand with age, but aged Trem2(-/-) mice had fewer microglia with an abnormal morphology which failed to amplify transcripts indicative of activation, phagocytosis, and lipid catabolism in response to myelin damage. PMID: 25893602
    37. Data (including data from studies using knockout mice) suggest that TREM2 is expressed on alveolar macrophages and lung mucosa and plays role innate immunity during pneumococcal pneumonia; knockout of TREM2 increases phagocytosis and survival. PMID: 24945405
    38. viral replication increases lung macrophage levels of intracellular and cell surface TREM-2, and this action prevents macrophage apoptosis PMID: 25897174
    39. TREM2 knockdown reduced microglial activation, decreased phagocytosis of injured neurons and worsened stroke damage. PMID: 25716838
    40. Upon infection with Escherichia coli, the otherwise beneficial effect of an exaggerated early immune response in TREM-2(-/-) animals was counteracted by a 50% reduction in bacterial phagocytosis. PMID: 25477281
    41. important role for TREM2 in inflammatory macrophages and neuroinflammation PMID: 25732305
    42. TREM2 detects damage-associated lipid patterns associated with neurodegeneration, sustaining the microglial response to beta-amyloid accumulation. PMID: 25728668
    43. TREM2 promotes adipogenesis and diet-induced obesity by upregulating adipogenic regulators in conjunction with inhibiting the Wnt10b/beta-catenin signaling pathway. PMID: 25114293
    44. It may play a protective role against aging-related neuroinflammation and cognitive impairment. PMID: 24368090
    45. These data suggest that TREM2 is important for the microglial response to Amyloid-beta deposition PMID: 24893973
    46. Results suggest that an epigenetic mechanism involving an aluminum-triggered, NF-kB-sensitive, miRNA-34a-mediated down-regulation of triggering receptor expressed in myeloid cells 2 (TREM2) expression may impair phagocytic responses. PMID: 23778113
    47. TREM-2-mediated bacterial killing is dependent on the activation of PI3K/Akt signaling. PMID: 24383713
    48. TREM2 protein is expressed only in microglia/macrophages and is developmentally downregulated in a region-dependent manner. PMID: 23977213
    49. TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. PMID: 24218563
    50. Trem-2 plays an important role in the host defense response to sepsis by enhancing bacterial clearance. PMID: 23721075

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性:
    Expressed in the brain, specifically in microglia (at protein level). Expressed in macrophages (at protein level). Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 亚洲综合色噜噜狠狠网站超清| 日本丰满熟妇videossex8k | 国产综合久久亚洲综合| 中文字幕爆乳julia女教师| 亚洲欧美综合区丁香五月小说| 久久综合给合久久国产免费| 欧美黑人巨大xxxxx视频| 人妻一本久道久久综合久久鬼色| 女人爽到高潮免费视频大全| 久久久久国产精品人妻aⅴ毛片| 亚洲无线码一区二区三区| 少妇人妻无码专区视频| 久久久国产一区二区三区四区小说| 欧美日韩无套内射另类| 无码日日模日日碰夜夜爽| 亚洲男人的天堂av手机在线观看| 午夜精品久久久久久久99热| 蜜臀av综合网| 国产精品青草久久久久福利99| 韩国日本三级在线观看| 中文精品久久久久人妻不卡| 国产精品ⅴ无码大片在线看| 医院人妻闷声隔着帘子被中出| 色哟哟免费视频播放网站| 国产精品区av| 欧美巨鞭大战丰满少妇| 久久中文字幕乱码久久午夜| 色在线亚洲视频www| 欧美日韩午夜群交多人轮换| 男女真人国产牲交a做片野外| 久久久女人与动物群交毛片| 亚洲欧美日韩v在线观看不卡| 免费无码黄网站在线看| 日日噜噜夜夜狠狠久久丁香五月| av无码久久久精品免费| 国产在线精品一区在线观看| 天堂а√在线中文在线| 无码人妻丰满熟妇区五十路在线| 免费观看日本污污ww网站| 久久精品国产99国产精品亚洲| 国产蝌蚪视频一区二区三区 |