在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TYRP1 Antibody, Biotin conjugated

  • 中文名稱:
    TYRP1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA025399LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) TYRP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    TYRP1; CAS2; TYRP; TYRRP; 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human 5,6-dihydroxyindole-2-carboxylic acid oxidase protein (91-186AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
  • 基因功能參考文獻(xiàn):
    1. The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype. PMID: 26450459
    2. TYRP1-dependent miR-16 sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16-binding sites on TYRP1 mRNA. PMID: 28991221
    3. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. PMID: 29087386
    4. DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively. PMID: 28186599
    5. Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma. PMID: 25837821
    6. Mutation in TYRP1 is associated with oculocutaneous albinism. PMID: 26252096
    7. Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity PMID: 26068396
    8. These data suggest that UVB-stimulated Ucn1 contributes to TRP1 production via the transcription of both Nurr-1 and Nur77. Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner. PMID: 25240771
    9. These data indicate that galectin-3 is a regulatory component in melanin synthesis affecting the expression of Tyrp-1. PMID: 25054620
    10. p53 regulation by TRP2 is not pervasive in melanoma. PMID: 24475287
    11. Due to mutation in Tyrp1 protein, it became more rigid and might disturb the structural conformation and catalytic function of the structure and might also play a significant role in inducing oculocutaneous albinism type III. PMID: 23862152
    12. in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation. PMID: 23416839
    13. High TYRP1/S100B mRNA expression in lymph node metastases from melanoma patients is associated with unfavourable clinical outcome. PMID: 23519055
    14. We report four Pakistani albinism mutations, including three SLC45A2 alleles and one 22-nucleotide deletion in TYRP1. PMID: 23190901
    15. identifed an arginine-to-cysteine change at a highly conserved residue in TYRP1 as a major determinant of blond hair in Solomon Islanders; this missense mutation predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode of inheritance PMID: 22556244
    16. We used the first ranked gene, tyrosinase-related protein 1 (TYRP1), further measured its expression in the validation population by real-time PCR and found it to be significantly correlated with distant metastasis-free survival. PMID: 22045183
    17. two novel mutations in TYRP1 gene in two Chinese patients with oculocutaneous albinism type 3 PMID: 21739261
    18. Case Report: Report a Japanese girl with oculocutaneous albinism type 3 and novel mutations in TYRP1 gene. PMID: 21996312
    19. This review focuses on TYRP1, a melanosomal protein involved in the pigmentary machinery of the melanocyte and often used as differentiation marker, with a special emphasis on its emerging roles in the malignant melanocyte and melanoma progression. PMID: 21324755
    20. interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
    21. Adoptive transfer of TRP1-specific T cells into -expressing recipients produces large confluent patches of vitiligo and ocular damage in TRP1-specific T cell receptor transgenic mice. PMID: 20668223
    22. Tyrp1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. Tyrp1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and melanocyte cell death. PMID: 11775055
    23. DNA sequence variants in the human TYRP1 gene are not associated with inherited pigmentary glaucoma in humans. PMID: 12011806
    24. We have identified the first TYRP1 mutation in non-Africans and have confirmed that TYRP1 mutations are associated with a milder phenotype of oculocutaneous albinism. PMID: 15996218
    25. The presence of a distal Tyrp1 regulatory element, which specifies melanocyte-specific expression, supports the idea that separate regulatory sequences can mediate differential gene expression in melanocytes and RPE. PMID: 16934245
    26. Melanocytes in vitiligo demonstrate reduced ability to withstand oxidative stress due, partly, to a disruption in microphthalmia-associated transcription factor regulation of Tyrp1. PMID: 17071589
    27. We observe strong evidence for positive selection for TYRP1 alleles in Africans and in Asians PMID: 18312627
    28. An eye color variant in TYRP1 was associated with risk of cutaneous melanoma. PMID: 18488027
    29. Mutation of TYRP1 (OCA3) can modify the OCA2 phenotype, resulting in red hair. PMID: 18680187
    30. Both TRP-1 and galectin-1 were highly expressed in normal melanocytes and melanoma. There was no correlation between TRP-1 or galectin-1 expression and survival. PMID: 19287070
    31. TYRP1 rs1408799 is associated with melanoma. PMID: 19384953

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Albinism, oculocutaneous, 3 (OCA3)
  • 亞細(xì)胞定位:
    Melanosome membrane; Single-pass type I membrane protein. Melanosome.
  • 蛋白家族:
    Tyrosinase family
  • 組織特異性:
    Pigment cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 12450

    OMIM: 115501

    KEGG: hsa:7306

    STRING: 9606.ENSP00000373570

    UniGene: Hs.270279



主站蜘蛛池模板: 亚洲超清无码制服丝袜无广告| 日韩精品一区二区三区中文| 无罩大乳的熟妇正在播放| 欧美一区二区日韩国产| 亚洲综合久久精品无码色欲| 女人爽到高潮视频免费直播| 亚洲蜜桃v妇女| 国模叶桐尿喷337p人体| 亚洲中文字幕乱码电影| 超caopor在线公开视频| 粗大的内捧猛烈进出视频| 国产一区二区精品丝袜| 亚洲精品国产精品制服丝袜 | 国产欧美va天堂在线电影| 69久久精品无码一区二区无码| 色诱视频在线观看| 国产成人精品久久亚洲高清不卡| 疯狂做受xxxx高潮欧美日本| 中文字幕精品视频在线看免费| 日本少妇自慰免费完整版| 大地资源网中文第五页| 国产亚洲精品久久久久久小舞 | 色欲av蜜桃一区二区三| 色欲色香天天天综合vvv| 五月花成人网| 在线亚洲高清揄拍自拍一品区| 特级毛片全部免费播放| 日本人妻巨大乳挤奶水| 国产熟妇搡bbbb搡bbbb| 电影内射视频免费观看| 亚洲精品无码不卡av| 日本特黄特色aaa大片免费| 中文www新版资源在线| 西西444www大胆无码视频| 在线不卡av片免费观看| 国产婷婷色一区二区三区| 国产成a人亚洲精v品无码| 香港特级三a毛片免费观看| 国产高清在线精品一区免费| 欧美日韩精品一区二区三区不卡| 看国产黄大片在线观看|