在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TXNRD2 Antibody

  • 中文名稱:
    TXNRD2兔多克隆抗體
  • 貨號:
    CSB-PA885675ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Thioredoxin reductase 2, mitochondrial antibody at 6μg/ml
      Lane 1: Mouse liver tissue
      Lane 2: Mouse gonad tissue
      Lane 3: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57, 54, 47, 31 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA885675ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA885675ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TXNRD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TXNRD2
  • 別名:
    mitochondrial antibody; Selenoprotein Z antibody; SelZ antibody; Thioredoxin reductase 2 antibody; Thioredoxin reductase 2 mitochondrial antibody; Thioredoxin reductase 3 antibody; Thioredoxin reductase beta antibody; Thioredoxin reductase TR3 antibody; TR 3 antibody; TR antibody; TR beta antibody; TR-beta antibody; TR3 antibody; TRXR 2 antibody; TRXR2 antibody; TRXR2_HUMAN antibody; TXNRD 2 antibody; Txnrd2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Thioredoxin reductase 2, mitochondrial protein (100-310AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
  • 基因功能參考文獻:
    1. Based on recent research, it has been reported that the modulation of the Trx/TrxR system may be considered as a new target in the management of the metabolic syndrome, insulin resistance, and type 2 diabetes, as well as in the treatment of hypertension and atherosclerosis. In this review evidence about a possible role of this system as a marker of the metabolic syndrome is reported. [review] PMID: 29327078
    2. TrxR2 was overexpressed in non-small-cell lung cancer cells; our results suggest that TrxR2 acts as an oncogenic gene in the context of lung cancer progression PMID: 28414076
    3. p53R2 acts as a positive regulator of TrxR2 activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage PMID: 27866984
    4. TrxR2 deficiency-induced impaired proliferation and death of chondrocytes may be the pathological mechanism of the osteoarthropathy due to Selenium deficiency. PMID: 27107686
    5. Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy. PMID: 26763822
    6. Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS). PMID: 26573231
    7. A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2, and FOXC1 PMID: 26752265
    8. The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin. PMID: 25703281
    9. Data suggest TXNRD1 and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults. PMID: 24624337
    10. Absence of TXNRD2 in humans leads to glucocorticoid deficiency. PMID: 24601690
    11. Single Nucleotide Polymorphisms in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population. PMID: 24058403
    12. Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance. PMID: 23597419
    13. Data suggest that dietary factor (selenium supplementation) up-regulates endogenous antioxidant systems and protects trophoblasts from oxidative stress; selenium upregulates GPX1 (glutathione peroxidase 1) and thioredoxin reductases (TXNRD1; TXNRD2). PMID: 23063346
    14. A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
    15. No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to Kashin-Beck disease. PMID: 20965815
    16. Mutation of this gene is involved in regulation of cellular redoc state in Dilated Cardiomyopathy. PMID: 21247928
    17. study reveals significant differences between TrxR1 and TrxR2 in substrate specificity and metal compound inhibition in vitro and in cells PMID: 21172426
    18. mammary tumors expressing the wild-type TR were readily suppressed by the IFN/RA combination. In contrast, the tumors bearing a mutant TR were resistant to regression. PMID: 12374691
    19. Mitochondrial thioredoxin reductase and peroxiredoxin III are overexpressed in hepatocellular carcinomas. PMID: 12530083
    20. Involvements of mitochondrial thioredoxin reductase in cell proliferation. PMID: 12705894
    21. the function of TR3 is not limited to its role in Trx2 reduction PMID: 16774913
    22. Nuclear extracts from rat lungs administered this reduced recombinant protein suggest a role for NF-kappaB in proinflammatory responses. PMID: 17395017
    23. The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer. PMID: 19035188
    24. Observations underpin a likely critical antioxidant role for TrxR2 and TrxR1 in the endothelium. PMID: 19595745
    25. Over-expression of TXNRD2, COMT and ARVCF affects incentive learning and working memory in transgenic mice. PMID: 19617637

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Class-I pyridine nucleotide-disulfide oxidoreductase family
  • 組織特異性:
    Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608
  • 數據庫鏈接:

    HGNC: 18155

    OMIM: 606448

    KEGG: hsa:10587

    STRING: 9606.ENSP00000383365

    UniGene: Hs.443430



主站蜘蛛池模板: 国产av无码专区亚汌a√| 中国人妻被两个老外三p| 私人家庭影院5777| 丰满熟妇乱子伦| 国产男女爽爽爽免费视频| 亚洲a∨国产av综合av| 日韩制服国产精品一区| 亚洲欭美日韩颜射在线| 亚洲最新无码中文字幕久久 | 高潮添下面视频免费看| 色妺妺av爽爽影院| 无码精品人妻一区二区三区98| 欧美丰满老妇性猛交| 无码无套少妇毛多69xxx| 蜜臀aⅴ国产精品久久久国产老师| 久久本色成人综合网| 亚洲国产成人爱av网站| 40岁成熟女人牲交片20分钟| 人成午夜大片免费视频77777| 中文无码伦av中文字幕在线| 亚洲跨种族黑人xxxxx| 日出水了特别黄的视频| 国产av一区二区三区天堂综合网| 五月丁香六月综合缴情在线| 老熟妇性老熟妇性色| 欧美一区二区| 97久久国产露脸精品国产| 女高中生自慰污污网站| 成人h动漫精品一区二区无码| 男女啪啪做爰高潮免费网站| 亚洲爆乳成av人在线蜜芽| 人妻换人妻a片爽麻豆| 亚洲精品国产品国语在线| 亚洲国产v高清在线观看| 亚洲人成色77777在线观看大战| 亚洲国产中文字幕在线视频综合| 中国熟妇牲交视频免费| 在线观看国产精品va| 国产网红无码精品视频| 无码精品日韩中文字幕| 色777狠狠狠综合|