在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TXN2 Antibody

  • 中文名稱:
    TXN2兔多克隆抗體
  • 貨號(hào):
    CSB-PA025366GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    TXN2 antibody; TRX2 antibody; Thioredoxin antibody; mitochondrial antibody; MTRX antibody; Mt-Trx antibody; Thioredoxin-2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TXN2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
  • 基因功能參考文獻(xiàn):
    1. Overexpression of mitochondrial Trx2 attenuates the intracellular ROS accumulation and ATP production. Most interestingly, mitochondrial Trx2 may be involved in the cardiac hypertrophy signaling of diabetes. PMID: 28914755
    2. Trx2 overexpression failed to attenuate hypoxia-induced human pulmonary arterial smooth muscle cells proliferation in vitro or hypoxia-induced Pulmonary hypertension in vivo. PMID: 28130258
    3. study demonstrated that miR-27a and -b, which are widely expressed in host cells, suppress SNAP25 and TXN2 expression through posttranscriptional gene silencing. PMID: 28356525
    4. No evidence that SNPs in TRX2 have effects, but the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy. PMID: 26763822
    5. Thioredoxin 2 Is a Novel E2-Interacting Protein That Inhibits the Replication of Classical Swine Fever Virus by promoting the nuclear translocation of the p65 subunit of NF-kappaB. PMID: 26041303
    6. The Grx2 system could help to keep Trx2/1 reduced during an oxidative stress, thereby contributing to the anti-apoptotic signaling. PMID: 24295294
    7. CERKL interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway. PMID: 24735978
    8. TGF-beta-mediated expression of the epithelial-mesenchymal transition marker fibronectin was inhibited not only by chemicals that interfere with reactive oxygen species signaling but also by exogenously expressed mitochondrial thioredoxin. PMID: 24342608
    9. We showed that overexpression of TRXs reduced cell death; TRX2 was expressed in the mitochondria, while TRX1 was expressed in the cytoplasm. PMID: 23485938
    10. knockdown of TRX-1 or TRX-2 sensitizes cells to CYP2E1-induced oxidant stress partially via ASK-1 and JNK1 signaling pathways. Both TRX-1 and TRX-2 are important for defense against CYP2E1-induced oxidative stress. PMID: 21557999
    11. Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA, all potential therapeutic targets in cancer. PMID: 21327297
    12. TRX1 and TRX2 regulate the proliferation and survival of adipocyte derived stem cells; these processes are mediated by the activation of ERK1/2 PMID: 21158569
    13. mitochondrial thioredoxin may play important roles in protection against oxidant-induced apoptosis PMID: 12032145
    14. MT-TRX has a role in the regulation of the mitochondrial membrane potential and cell death PMID: 12080052
    15. Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha. PMID: 17220299
    16. The LC/ICPMS analyses showed that the trivalent arsenic species were able to form complexes with both human and E. coli Trx. PMID: 17939155
    17. upon stimulation of Fas, thioredoxin-2 mediated denitrosylation of mitochondria-associated caspase-3, a process required for caspase-3 activation, and promoted apoptosis PMID: 18497292
    18. a novel Ins/Del polymorphism in the human TXN2 gene proximal promoter region that altered the transcriptional activity and is associated with spina bifida risk PMID: 19165900
    19. Trx2 modulates transcription of GR and NF-kappaB reporter genes. PMID: 19570036
    20. These results suggest that TRX2 not only functions as an antioxidant, but also supports mtTFA functions PMID: 19885567

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Combined oxidative phosphorylation deficiency 29 (COXPD29)
  • 亞細(xì)胞定位:
    Mitochondrion.
  • 蛋白家族:
    Thioredoxin family
  • 組織特異性:
    Widely expressed in adult (at protein level) and fetal tissues.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 17772

    OMIM: 609063

    KEGG: hsa:25828

    STRING: 9606.ENSP00000216185

    UniGene: Hs.211929



主站蜘蛛池模板: 少妇被猛男粗大的猛进出| 国产成人综合日韩精品无码不卡| 丰满岳妇乱一区二区三区| 国产欠欠欠18一区二区| 久久久久爽爽爽爽一区老女人| 黑人尾随强伦姧人妻爽翻天| 老女老肥熟国产在线视频| 野花社区视频www官网| 青娱乐极品视觉盛宴国产视频 | 国产素人在线观看人成视频| 久久99av无色码人妻蜜| 国产熟女内射oooo| 国产亚洲日韩欧美另类第八页| 亚洲第一成年免费网站| 日本免费一本一二区三区| 内射爽无广熟女亚洲| 99久久综合狠狠综合久久止| 国产精品99久久精品爆乳| 久久国产精品无码hdav| 一区二区狠狠色丁香久久婷婷| 国产深夜男女无套内射| 欧美又大粗又爽又黄大片视频| 97影院理论午夜伦不卡| 国产av成人无码精品网站| 窝窝午夜看片| 美女张开腿黄网站免费| 狠狠色丁香婷婷综合尤物| 岛国在线无码高清视频| 亚洲精品人成无码中文毛片| 欧美孕妇变态重口另类| 色综合欧美亚洲国产| 欧美阿v高清资源在线| 国产又粗又猛又黄又爽无遮挡| 亚洲欧美综合区丁香五月小说| 扒开双腿猛进入喷水高潮叫声| 欧美最新精品videossexohd | 亚洲一区精品二人人爽久久| 女人被男人桶30分钟无遮挡动态图| 国产超碰人人做人人爱| 免费裸体美女网站| 狼人大香伊蕉国产www亚洲|