在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TXN Antibody

  • 中文名稱:
    TXN兔多克隆抗體
  • 貨號:
    CSB-PA281213
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA281213(TXN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA281213(TXN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 cells, hela cells, Primary antibody: CSB-PA281213(TXN Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ADF antibody; ATL derived factor antibody; ATL-derived factor antibody; DKFZp686B1993 antibody; MGC61975 antibody; SASP antibody; Surface associated sulphydryl protein antibody; Surface-associated sulphydryl protein antibody; testicular tissue protein Li 199 antibody; THIO_HUMAN antibody; Thioredoxin antibody; thioredoxin delta 3 antibody; TRDX antibody; TRX 1 antibody; Trx antibody; TRX1 antibody; TXN antibody; TXN delta 3 antibody; TXN protein antibody; zgc:92903 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Rat
  • 免疫原:
    Synthetic peptide of Human TXN
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.; ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
  • 基因功能參考文獻:
    1. Data suggest that TSTD1 can utilize thioredoxin as an acceptor in the presence of thioredoxin reductase and NADPH. (TSTD1 = thiosulfate sulfurtransferase-like domain-containing 1 protein) PMID: 29348167
    2. Based on recent research, it has been reported that the modulation of the Trx/TrxR system may be considered as a new target in the management of the metabolic syndrome, insulin resistance, and type 2 diabetes, as well as in the treatment of hypertension and atherosclerosis. In this review evidence about a possible role of this system as a marker of the metabolic syndrome is reported. [review] PMID: 29327078
    3. By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13. PMID: 30104382
    4. TRX1 is an actionable castration-resistant prostate cancer therapeutic target through its protection against AR-induced redox stress. PMID: 29089489
    5. Trx-1 may be an important target for delaying oral malignant transformation, which provides a novel therapeutic strategy for the prevention and treatment of oral squamous cell carcinoma. PMID: 29328386
    6. Results found the mRNA level of TRX-1 was significantly decreased (p<0.005), while the mRNA levels of TBP-2, COX-2, and TNF-alpha were significantly increased in the placentas in preeclampsia when compared to the normal group. PMID: 29999276
    7. This study quantified the contribution of Trx reductase to the redox status of Trx, demonstrating that the redox profile of Trx is determined by the interplay between the elevation of intracellular redox potential and the reduction by Trx reductase and other endogenous molecules. PMID: 29509009
    8. We identified a novel Jab1-Trx axis that is a key cellular process in the pathobiologic characteristics of acute myeloid leukemia (AML-M5). Targeting the ROS/Jab1/Trx pathway could be beneficial in the treatment of AML-M5 PMID: 28270496
    9. study indicates that TRX levels cannot be used as a marker for Treatment Resistant Depression (trd) or repetitive transcranial magnetic stimulation treatment in TRD. In spite of this TRX levels have a positive correlation with language functions of the patients. PMID: 28442424
    10. The reducing system of PTEN was comprised of NADPH, thioredoxin reductase (TrxR1), and thioredoxin (Trx). PMID: 28774816
    11. Thioredoxin 1 modulates signaling mechanisms in the heart via its molecular targets, including transcription factors, microRNAs, histone deactylases, and protein kinases. (Review) PMID: 27993729
    12. The ratio of thioredoxin/Keap1 protein level may be useful for suggesting distant metastasis in colorectal cancer. PMID: 29053012
    13. Overexpression of NOS3 increased the levels and activities of proteins of the redoxin systems, Trx1, Grx1, TrxR1 and TxnIP, and the levels of signaling proteins (Akt1, pAkt1(-)Ser473, MapK, pMapK, Stat3, Fas). PMID: 28162284
    14. Increased serum thioredoxin concentrations are highly associated with trauma severity PMID: 28347674
    15. Plasma-TRX on day 1 was significantly increased in patients who later developed post-injury sepsis. In a logistic regression analysis including TRX, C-reactive protein, injury severity, massive transfusion, and admission blood pressure, TRX was the only variable independently associated with post-injury sepsis PMID: 28087409
    16. High TRX1 expression is associated with myocardial infarction. PMID: 26933812
    17. Data show that suberoylanilide hydroxamic acid (SAHA) induced apoptosis via the down-regulation thioredoxin1 (Trx1), which was regulated by microRNA miR-129-5p. PMID: 28667779
    18. Analysis of 25 independent cohorts with 5910 patients showed that Trx1 and TrxR1 were both associated with a poor patient prognosis in terms of overall survival, distant metastasis free survival and disease free survival. PMID: 26760912
    19. these findings demonstrate that Trx1 is a critical regulator of necroptosis that suppresses cell death by maintaining MLKL in a reduced inactive state. PMID: 28878015
    20. Study shows that TRX1 and APEX1 expressions are up regulated in new Multiple Sclerosis (MS) patients compared to controls and might be implicated in pathogenesis of the disease. PMID: 28844667
    21. CD40 activation resulted in down-regulation of Thioredoxin (Trx)-1 to permit ASK1 activation and apoptosis. Although soluble receptor agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 agonist and pharmacological inhibition of Trx-1 was functionally equivalent to the signal triggered by mCD40L PMID: 27869172
    22. our findings identify the TXN-FOXO1-p300 circuit as the sensor and effector of oxidative stress in DLBCL cells PMID: 27132507
    23. Novel positive feedback loop between Trx-1 and S100P promotes colorectal cancer invasion and metastasis. PMID: 28483515
    24. Thioredoxin attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NOX2-NOX4 activity. PMID: 28688762
    25. from the two catalytic cysteines of TRX1 the residue C32 is responsible for the high-affinity binding of TRX1 to the ASK1-TRX-binding domain in reducing conditions PMID: 27588831
    26. findings suggest that the up-regulated RRM1 and hTrx1 in colorectal cancer directly interact with each other and promote RR activity, resulting in enhanced DNA synthesis and cancer malignancy. PMID: 28411237
    27. Trx and its target proteins involved in redox signaling are critical for the control of cell fate such as cell survival and apoptosis [review] PMID: 27665998
    28. herefore, the length of treatment with Nrf2 activators and/or Trx-1 has first to be studied in more detail in cardiovascular disorders. Moreover, a combination of Nrf2 activators and Trx-1 should be investigated and taken into consideration. PMID: 27923281
    29. In an in vivo model of restenosis, which is characterized by oxidative stress, endothelial activation, and smooth muscle cell proliferation, Thioredoxin-1 protein levels are reduced in the endothelium of the carotids. APEX1 acts anti-apoptotic in endothelial cells. This anti-apoptotic effect depends on the first 20 amino acids of APEX1 PMID: 27835927
    30. Authors found that TXN was under expressed in both AML and ALL groups as compared to the control group. Also TXN expression level was negatively correlated with serum 8-OHdG and tail moment in both AML and ALL. PMID: 27158980
    31. Increased S-Trx and U-Trx concentrations, especially U-Trx/cr ratio, are closely associated with the severity of children hydronephrosis, substantializing Trx as a promising biomarker for the progression of children hydronephrosis PMID: 28111273
    32. TRX in postoperative serum may be a potential biomarker to predict development of postoperative delirium and cognitive dysfunction in elderly patients undergoing hip fracture surgery. PMID: 28093200
    33. Serum levels of thioredoxin and DJ-1 were significantly higher in non-small cell lung cancer patients; therefore, these may be utilized as novel diagnostic and prognostic biomarkers for non-small cell lung cancer PMID: 26334622
    34. Elevated plasma thioredoxin levels are correlated with the severity and poor prognosis in subarachnoid hemorrhage patients. PMID: 27000227
    35. Data show that the overexpression of thioredoxin1 (Trx1) attenuated apoptosis and reactive oxygen species (ROS) level in lung cancer cells. PMID: 26460805
    36. Based on its collective anti-oxidative, cytoprotective, and cytokine-like properties of TRX, TRX is likely to be involved in the optimal growth and maturation of ovarian follicles and responsiveness to hyperstimulation. PMID: 26536897
    37. change of serum levels of thioredoxin in patients with severe traumatic brain injury PMID: 26656445
    38. Serum TRX levels at admission were associated with stroke severity and lesion volumes. PMID: 25520003
    39. Results indicate that reduced Trx1 plays important protective roles against methyl methanesulfonate-induced DNA damage and cell death, suggesting that cell protection is regulated by the intracellular redox state. PMID: 26276860
    40. The results demonstrate that the antiproliferative effect of NO is hampered by Trx1 and Grx1 and support the strategy of weakening the thiolic antioxidant defenses when designing new antitumoral therapies. PMID: 26210445
    41. differential expression in children with allergic asthma PMID: 25979194
    42. identification of the novel interaction between Trx1 and AIF has provided opportunities to design and develop therapeutically relevant strategies that either promote or prevent this protein-protein interaction for the treatment of different disease PMID: 26119781
    43. Thioredoxin 1 mediates TGF-beta-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. PMID: 26325518
    44. In Jurkat cells exposed to ionizing radiatin (4 Gy), constitutively active Trx systems respond to restore cellular redox balance. After 16 hrs, Trx increases and rescues cells against IR-mediated damage. PMID: 26021764
    45. genetic variants of TXN and COMT have roles in regulating abdominal obesity PMID: 26329592
    46. Trx1 inhibition results in reactive oxygen species-induced apoptosis in Multiple myeloma cells, sensitizes Multiple myeloma cells to the NF-small ka, Cyrillicbeta inhibitors, and also induces apoptosis in bortezomib-resistant myeloma cells. PMID: 25945832
    47. thioredoxin is a remote ischemic preconditioning-induced factor in heart tissue of cardiosurgical patients. PMID: 25622749
    48. Plasma TRX levels of male patients in a manic episode were significantly lower than the controls. PMID: 25297388
    49. the overexpression and nuclear translocation of thioredoxin-1 (Trx-1) are closely associated with hypoxia-drug resistance through the regulation of the metabolism by the oxidative stress response to glycolysis. PMID: 25656992
    50. The crystal structure of fully oxidized thioredoxin shows a non-active Cys62-Cys69 disulfide bond in addition to the active Cys32-Cys35 disulfide. PMID: 26453009

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Secreted.
  • 蛋白家族:
    Thioredoxin family
  • 數據庫鏈接:

    HGNC: 12435

    OMIM: 187700

    KEGG: hsa:7295

    STRING: 9606.ENSP00000363641

    UniGene: Hs.435136



主站蜘蛛池模板: 国产精品视频一区二区噜噜| 天堂网www天堂资源网| 国产老熟女狂叫对白| 久久久亚洲精品一区二区三区浴池 | 久久99国产只有精品| 在线v片免费观看视频| 狠狠色丁香久久婷婷综合蜜芽五月| 久久婷婷五月综合色国产| 国产精品久久777777| 国产破外女出血视频| 亚洲爆乳aaa无码专区| 一本大道东京热无码一区| 日韩丰满少妇无吗视频激情内射| 老师黑色丝袜被躁翻了av| 野花社区www视频最新资源| 99久热re在线精品99 6热视频| 欧美老熟妇又粗又大| 国产无限次数成版人视频在线| 国产女人喷潮视频在线观看| 国产欧美日韩综合精品一区二区| 偷看少妇自慰xxxx| 午夜性色吃奶添下面69影院| 久久伊人av综合影院| 人妻大战黑人白浆狂泄| 成人区精品一区二区不卡| 人妻无码中文字幕永久在线| 国产超碰人人模人人爽人人添| 日本三级成本人网站| 亚洲第一狼人天堂久久| 久久久中日ab精品综合 | 天堂一区人妻无码| 亚洲乱码av一区二区| 男女性高爱潮免费观看| 国产成人精品优优av| 丁香五月亚洲综合深深爱| 中文字幕 乱码 中文乱码视频| 成人小说亚洲一区二区三区| 99久久久无码国产精品古装 | 精品精品国产理论在线观看| 蜜臀av无码精品人妻色欲| 久久se精品一区精品二区|