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  4. TWF1 Antibody, Biotin conjugated

TWF1 Antibody, Biotin conjugated

  • 中文名稱：
    TWF1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA622511LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TWF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    A6 antibody; A6 protein tyrosine kinase antibody; MGC105817 antibody; MGC23788 antibody; MGC41876 antibody; Protein A6 antibody; Protein tyrosine kinase 9 antibody; PTK9 antibody; PTK9 protein tyrosine kinase 9 antibody; TWF 1 antibody; twf1 antibody; TWF1_HUMAN antibody; Twinfilin 1 antibody; Twinfilin actin binding protein, homolog 1 antibody; Twinfilin antibody; Twinfilin, actin-binding protein, homolog 1 (Drosophila) antibody; Twinfilin, Drosophila, homolog of, 1 antibody; Twinfilin-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Twinfilin-1 protein (199-252AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
  • 基因功能參考文獻：
    1. Univariate Cox regression analysis showed high expression of TWF1 to be independent prognostic indicator involved in overall survival and recurrence-free survival in lung adenocarcinoma, but not in lung squamous cell carcinoma PMID: 30391462
    2. TWF1 and VIM are required for miR-30c to regulate breast cancer cell invasion. PMID: 23224145
    3. An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. PMID: 23340433
    4. protein overexpression promotes cardiomyocyte hypertrophy PMID: 20571053
    5. These data suggest that the association with an actin monomer induces a first-order conformational change within the twinfilin molecule. PMID: 12429826
    6. mammals have two twinfilin isoforms, which are differentially expressed and regulated through distinct cellular signaling pathways PMID: 12807912

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  • 相關疾病：
    Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Actin-binding proteins ADF family, Twinfilin subfamily
  • 組織特異性：
    Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
  • 數據庫鏈接：

    HGNC: 9620

    OMIM: 610932

    KEGG: hsa:5756

    STRING: 9606.ENSP00000449428

    UniGene: Hs.189075



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