在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TUBB4A Antibody, HRP conjugated

TUBB4A Antibody, HRP conjugated

  • 中文名稱：
    TUBB4A兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA025324LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TUBB4A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Beta 4 antibody; Beta 4 tubulin antibody; beta 5 antibody; beta four tubulin antibody; Dystonia 4 torsion (autosomal dominant) antibody; MC1R antibody; TBB4_HUMAN antibody; TUB B4 antibody; TUBB 4 antibody; tubb4 antibody; TUBB4A antibody; TUBB5 antibody; Tubulin 5 beta antibody; Tubulin beta 3 antibody; Tubulin beta 4 antibody; Tubulin beta 4 chain antibody; Tubulin beta 4A class IVa antibody; Tubulin beta 5 antibody; Tubulin beta IV antibody; Tubulin beta-4 chain antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tubulin beta-4A chain protein (1-444AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻：
    1. The data of this studies suggest that mutations in TUBB4A exceedingly rarely contribute to the etiology of isolated dystonia. PMID: 28655586
    2. The different clinical phenotypes associated with TUBB4A reflect the selective and specific cellular effects of the causative mutations. Cellular specificity of disease pathogenesis is relevant to developing targeted treatments for this disabling condition. PMID: 28973395
    3. Together, DYT4-associated TUBB4A mutants themselves form aberrant tubulin networks and inhibit neuronal process growth, possibly explaining progress through the pathological states at cellular levels. PMID: 29127012
    4. Genetic screening targeted at currently known disease-causing mutations in TOR1A, THAP1, and TUBB4 appears to have low diagnostic yield in sporadic spasmodic dysphonia. In our cohort, only 2 patients tested positive for novel/rare variants in THAP1. PMID: 27188707
    5. TUBB4A-mutated patients manifest a comparable clinical and neuroimaging picture but they can differ from each other in terms of rate of disease progression PMID: 26643067
    6. our data indicate that TUBB4A coding mutations do not play a critical role in the broad population of isolated dystonia patients PMID: 26318963
    7. a paclitaxel-resistant beta-tubulin isotype, betaIVa-tubulin, was the most up-regulated gene compared with other beta-tubulin isotypes in H460 floating cells, concomitant with elevated ERK activation PMID: 26375501
    8. The study adds complicated hereditary spastic paraplegia to the clinical spectrum of TUBB4A-associated neurological disorders. PMID: 25772097
    9. Data suggested H-ABC and DYT4 belong to a continuous phenotypic spectrum associated with TUBB4A mutations. PMID: 25545912
    10. Novel TUBB4A mutations and expansion of the neuroimaging phenotype of hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC). PMID: 24706558
    11. Novel TUBB4A mutations expands the phenotype of TUBB4A-related hypomyelinating conditions beyond hypomyelination with atrophy of the basal ganglia and cerebellum. PMID: 25085639
    12. This study demonistrated that Hypomyelination with atrophy of the basal ganglia and cerebellum with TUBB4A mutation. PMID: 24785942
    13. TUBB4A mutations cause typical hypomyelinating leukoencephalopathies. PMID: 24850488
    14. The c.4C>G DYT4 mutation appears to be private, and clinical testing for TUBB4A mutations is not justified in spasmodic dysphonia or other forms of primary dystonia PMID: 24598712
    15. This study demonistrated that TUBB4A mutation in the autoregulatory domain cause hereditary dystonia. PMID: 23424103
    16. This study provided strong evidence supporting the causative role of a mutation in TUBB4, altering a highly conserved and functionally important amino acid, in DYT4 dystonia. PMID: 23595291
    17. Data indicate that leucine-rich repeat kinase 2 (LRRK2) selectively interacts with three beta-tubulin isoforms: TUBB, TUBB4, and TUBB6. PMID: 24275654
    18. DYT4 is a familial form of dystonia unrelated to known dystonia genes and loci. Phenotypic expression is variable, ranging from isolated spasmodic dysphonia (often with mild craniocervical dystonia) to severe generalized dystonia. PMID: 21956287
    19. A de novo mutation in the beta-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum. PMID: 23582646
    20. Destruction of the beta-tubulin:CCT-beta complex provokes Hsp90-dependent protein ubiquitination and degradation. PMID: 23190606
    21. Data show six differentially expressed proteins were identified as HSP70, PPIA and alpha-Enolase (up-regulated) S100-A9, PIMT and beta-5 tubulin (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis. PMID: 21839816
    22. The results provide the first evidence that a specific isoform of beta-tubulin is required for mitosis. PMID: 18553364
    23. Suggest that nuclear accumulation of soluble tubulin is part of an intrinsic defense mechanism, which tends to limit cell proliferation under pathological conditions. PMID: 19299461

    顯示更多

    收起更多

  • 相關疾病：
    Dystonia 4, torsion, autosomal dominant (DYT4); Leukodystrophy, hypomyelinating, 6 (HLD)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    Major isotype in brain, where it represents 46% of all beta-tubulins. In the brain, highest expression levels in the cerebellum, followed by putamen and white matter. Moderate levels in testis. Very low levels, if any, in other tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20774

    OMIM: 128101

    KEGG: hsa:10382

    STRING: 9606.ENSP00000264071

    UniGene: Hs.110837



主站蜘蛛池模板： 潮喷失禁大喷水av无码| 久久er99热精品一区二区| 亚洲精品乱码久久久久久| 国产99在线 | 免费| 影音先锋中文无码一区| 国产亚洲精品久久一区二区| 亚洲精品成人网站在线观看| 国产午夜福利短视频| 麻豆国产97在线 | 欧美| 国产av一区二区三区天堂综合网| 欧美日产国产新一区| 顶级欧美熟妇高潮xxxxx| 亚洲精品成av人片天堂无码| 亚洲日韩中文字幕无码一区 | 色舞月亚洲综合一区二区| 国产一区二区丝袜高跟鞋| 啪啪无码人妻丰满熟妇| 国产特级毛片aaaaaa毛片| 人与禽交av在线播放| 男人猛戳女人30分钟视频大全| 国产午夜草莓视频在线观看| 免费观看的av毛片的网站| 蜜臀av在线播放| 国产产无码乱码精品久久鸭| 无码国内精品久久人妻蜜桃| 777米奇色狠狠俺去啦| 亚洲熟妇丰满多毛xxxx| 国产人妻人伦精品1国产丝袜 | 99久久婷婷国产综合精品电影| 亚洲人成精品久久久久桥| 日本亲子乱子伦xxxx50路| 青青草原精品资源站久久| 激情五月婷婷| 亚洲精品久久久久中文第一幕| 久久精品亚洲国产av老鸭网| 久久久久久综合岛国免费观看 | www国产亚洲精品| 国产精品成人永久在线四虎| 国产精品_九九99久久精品| 成人无码亚洲精品无码| 日本熟妇浓毛hdsex|