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Your Good Partner in Biology Research

TTF2 Antibody

  • 中文名稱:
    TTF2兔多克隆抗體
  • 貨號:
    CSB-PA120090
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA120090(TTF2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    F2 antibody; Factor 2 antibody; Factor2 antibody; HuF 2 antibody; HuF2 antibody; Human factor 2 antibody; Lodestar homolog antibody; Lodestar protein antibody; RNA polymerase II termination factor antibody; Transcription release factor 2 antibody; Transcription termination factor 2 antibody; Transcription termination factor RNA polymerase II antibody; TTF2 antibody; TTF2_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human TTF2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:5-1:20
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
  • 基因功能參考文獻:
    1. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing PMID: 12927788
    2. TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase. PMID: 15125840
    3. Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes. PMID: 15467445
  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
  • 蛋白家族:
    SNF2/RAD54 helicase family
  • 數據庫鏈接:

    HGNC: 12398

    OMIM: 604718

    KEGG: hsa:8458

    STRING: 9606.ENSP00000358478

    UniGene: Hs.32333



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