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  4. TSPEAR Antibody, Biotin conjugated

TSPEAR Antibody, Biotin conjugated

  • 中文名稱：
    TSPEAR兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA848817LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TSPEAR Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TSPEAR
  • 別名：
    Thrombospondin-type laminin G domain and EAR repeat-containing protein antibody; TSEAR_HUMAN antibody; TSP-EAR antibody; TSPEAR antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Thrombospondin-type laminin G domain and EAR repeat-containing protein (248-433AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
  • 基因功能參考文獻：
    1. TSPEAR mutation is associated with tooth agenesis. PMID: 30046887
    2. using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter PMID: 27736875
    3. TSPEAR expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    4. TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice. PMID: 22678063
    5. The TSPEAR/C21orf29 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980

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  • 相關疾病：
    Deafness, autosomal recessive, 98 (DFNB98)
  • 亞細胞定位：
    Secreted. Cell surface. Cell projection, stereocilium.
  • 數據庫鏈接：

    HGNC: 1268

    OMIM: 612920

    KEGG: hsa:54084

    STRING: 9606.ENSP00000321987

    UniGene: Hs.660703



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