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TSPAN33 Antibody, FITC conjugated

  • 中文名稱：
    TSPAN33兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA768209LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TSPAN33 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TSPAN33
  • 別名：
    TSPAN33; PEN; Tetraspanin-33; Tspan-33; Penumbra; hPen; Proerythroblast new membrane
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tetraspanin-33 protein (118-235AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
  • 基因功能參考文獻：
    1. The results suggest that TSPAN33 represents a new control element in the development of inflammation by macrophages that could constitute a potential therapeutic target. PMID: 27574297
    2. Data show that tetraspanin 33 (tspan33) is an early activation marker, and that disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) protein expression does not correlate with Tspan33 expression in B cells. PMID: 28449222
    3. TSPAN33 is overexpressed in activated and malignant B cells. PMID: 24211713
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Cytoplasm.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 組織特異性：
    Predominantly expressed in erythroblasts.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28743

    OMIM: 610120

    KEGG: hsa:340348

    STRING: 9606.ENSP00000289407

    UniGene: Hs.27267



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