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  4. TSEN15 Antibody, HRP conjugated

TSEN15 Antibody, HRP conjugated

  • 中文名稱：
    TSEN15兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA840989LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TSEN15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TSEN15
  • 別名：
    TSEN15 antibody; C1orf19 antibody; SEN15 antibody; tRNA-splicing endonuclease subunit Sen15 antibody; SEN15 homolog antibody; HsSEN15 antibody; tRNA-intron endonuclease Sen15 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
  • 基因功能參考文獻：
    1. results demonstrate that mutations in any known subunit of the TSEN complex can cause pontocerebellar hypoplasia and progressive microcephaly, emphasizing the importance of its function during brain development PMID: 27392077
    2. A candidate SNP associated with the tRNA-splicing protein gene TSEN15 was independently associated with the risk of atrial fibrillation. PMID: 24944287
  • 相關疾病：
    Pontocerebellar hypoplasia 2F (PCH2F)
  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    SEN15 family
  • 組織特異性：
    Widely expressed. Highly expressed in testis and uterus.
  • 數據庫鏈接：

    HGNC: 16791

    OMIM: 608756

    KEGG: hsa:116461

    STRING: 9606.ENSP00000355299

    UniGene: Hs.548197



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