在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRPV5 Antibody

  • 中文名稱:
    TRPV5兔多克隆抗體
  • 貨號:
    CSB-PA885690ESR1HU
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TRPV5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TRPV5
  • 別名:
    TRPV5; ECAC1; Transient receptor potential cation channel subfamily V member 5; TrpV5; Calcium transport protein 2; CaT2; Epithelial calcium channel 1; Osm-9-like TRP channel 3; OTRPC3
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transient receptor potential cation channel subfamily V member 5 protein (1-325AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
  • 基因功能參考文獻:
    1. The alterations may lead to misfolding of TRPV5, reduction in translocation of the channel to the plasma membrane and/or impaired Ca(2+) transport function of the channel, and ultimately disrupt TRPV5-mediated Ca(2+) reabsorption. PMID: 28847730
    2. These findings indicate that the A563T variation induces structural, dynamical, and electrostatic changes in the TRPV5 pore, providing structural insight into the functional alterations associated with the A563T variation. PMID: 26837804
    3. Data found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype PMID: 26089600
    4. High TRPV5 expression is aassociated with adenoma of parathyroid glands. PMID: 25164318
    5. Klotho up-regulates TRPV5 from both the inside and outside of cells. PMID: 25378396
    6. Decreased expression of TRPV5 is associated with non-small cell lung cancer. PMID: 24761864
    7. Upregulating the expression of TRPV5 can be utilized to manipulate transmembrane Ca2+ transport, and may serve as an alternative for the treatment of Ca2+ balance-related diseases. PMID: 25139832
    8. Data indicate that transient receptor potential vanilloid type 5 (TRPV5) plasma membrane retention is regulated via lipid rafts. PMID: 23970553
    9. urinary plasmin could contribute to the downstream effects of proteinuria on the tubulointerstitium by negatively modulating TRPV5 PMID: 23024298
    10. apically secreted tissue transglutaminase functions as an inhibitor of TRPV5 and thereby contributes to the regulation of body Ca2+ homeostasis. PMID: 21952826
    11. Data show that calmodulin negatively modulates TRPV5 activity, which is reversed by parathyroid hormone-mediated channel phosphorylation. PMID: 21576356
    12. A calmodulin binding site was located in the C-termini of TRPV2 (654-683) and TRPV5 (587-616). PMID: 20686800
    13. WNK4 and NHERF2 synergistically regulate TRPV5 by enhancing its forward trafficking and increasing its stability at plasma membrane, respectively. PMID: 21187068
    14. G(2)/M cell cycle arrest was preceded by activation of TRPV5/6-like nonselective cation channels in the plasma membrane resulting in an elevated Ca(2+) entry as evident from fura-2 Ca(2+) imaging. PMID: 21063097
    15. TRPV5 channel is susceptible for helix breaking mutations and the proximal intracellular region of TM5 of this channel plays an important role in Ca(2+)-dependent inactivation PMID: 21035851
    16. Findings suggest that TRPV-5 contributes to maintaining the homeostasis of the human skeleton via a negative feedback loop in RANKL-induced bone resorption. PMID: 20547482
    17. Functional properties of the epithelial Ca2+ channel, ECaC. PMID: 11765215
    18. does not play a primary role in autosomal dominant hypercalciuria PMID: 12198212
    19. Our results indicate that the pattern of CaT1 and CaT2 expression correlates with the Ca2+ uptake potential along the differentiation of cultured human trophoblasts isolated from term placenta PMID: 12390878
    20. The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. PMID: 16291808
    21. WNK4 positively regulates TRPV5-mediated Ca transport & inhibitory effect of thiazide-sensitive Na+Cl- cotransporter on this process may be involved in pathogenesis of hypercalciuria of familial hyperkalemic hypertension caused by gene mutation in WNK4. PMID: 17018846
    22. TRPV5 is involved in regulation and function in renal Ca2+ reabsorption and overall Ca2+ homeostasis--{review} PMID: 17217059
    23. malin ubiquitinates PTG in a laforin-dependent manner, both in vivo and in vitro, and targets PTG for proteasome-dependent degradation. These results suggest an additional mechanism, involving laforin and malin, in regulating glycogen metabolism PMID: 18077461
    24. activation of protein kinase C increases cell surface abundance of TRPV5 by inhibiting endocytosis PMID: 18305097
    25. review covers the distinctive properties and regulation of the highly Ca(2+)-selective TRPV5 channel and highlights the implications for our understanding of the process of Ca(2+) reabsorption. PMID: 18596722
    26. This study was aimed at the mechanism underlying the difference in the effects of WNK4 on TRPV5 and TRPV6 through analyzing the difference in TRPV5 and TRPV6 expression in the plasma membrane. PMID: 18703016
    27. Genotyping TRPV5 in renal hypercalciuria revealed three non-synonymous and five synonymous polymorphisms. Electrophysiological study of the TRPV5 mutants did not reveal significant functional changes compared to wild-type TRPV5 channel recordings. PMID: 19131347
    28. The expression pattern and the selective Ca2+ permeation properties of TRPV5 channel indicate an important role of this channel in the Ca2+ homeostasis. PMID: 19140341
    29. Activation of the CaR stimulates TRPV5-mediated Ca(2+) influx via a PMA-insensitive PKC isoform pathway. PMID: 19157541
    30. the A563T variation in TRPV5 may contribute to the superior ability of renal Ca(2+) conservation in African Americans PMID: 19261737
    31. Parathyroid hormone activates the cAMP-PKA signaling cascade, which rapidly phosphorylates threonine-709 of TRPV5, increasing the channel's open probability and promoting Ca(2+) reabsorption in the distal nephron. PMID: 19423690

    顯示更多

    收起更多

  • 亞細胞定位:
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV5 sub-subfamily
  • 組織特異性:
    Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
  • 數據庫鏈接:

    HGNC: 3145

    OMIM: 606679

    KEGG: hsa:56302

    STRING: 9606.ENSP00000265310

    UniGene: Hs.283369



主站蜘蛛池模板: 99re久久热在这里精品| 豆国产96在线 | 亚洲| 欧美黑人欧美精品刺激| 精品国产精品久久一区免费式| 精品无码欧美黑人又粗又| 大屁股国产白浆一二区| 高清免费精品国自产拍| 国自产偷精品不卡在线| 人人澡超碰碰97碰碰碰| 国产精品无码综合区| 精品一卡2卡三卡4卡乱码精品视频| 成人午夜精品无码一区二区三区 | 色偷偷色噜噜狠狠网站年轻人| 中国少妇内射xxxx狠干| 欧美成人家庭影院| 野花社区在线www日本| 一二三四观看视频社区在线| 日韩中文字幕在线专区| 欧洲熟妇精品视频| 欧美老熟妇喷水| 亚洲成av人片在www| 国内乱码一线二线三线| 日本一卡2卡3卡4卡无卡免费网站| 国产精品久久久久影院嫩草| 做爰高潮视频免费的看| 九九99久久精品在免费线18| aⅴ亚洲 日韩 色 图网站 播放| 欧美老妇与禽交| 成人精品一区二区三区中文字幕| 中文字日产乱码免费1~3软件 | 狠狠色噜噜狠狠狠狠米奇777| 九九综合va免费看| 青草草在线视频永久免费| 男人用嘴添女人私密视频| 国产成人剧情av麻豆果冻| 中文字幕丝袜第1页| 国产剧情av麻豆香蕉精品| 久国产精品人妻aⅴ| 国产成人无码av大片大片在线观看| 成人无码亚洲精品无码| 亚洲精品色在线网站|