在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TRPM5 Antibody

TRPM5 Antibody

  • 中文名稱：
    TRPM5兔多克隆抗體
  • 貨號：
    CSB-PA025087GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TRPM5
  • 別名：
    9430099A16Rik antibody; Long transient receptor potential channel 5 antibody; LTrpC-5 antibody; LTrpC5 antibody; MLSN1 and TRP related gene 1 antibody; MLSN1 and TRP related gene 1 protein antibody; MLSN1 and TRP-related antibody; MLSN1- and TRP-related gene 1 protein antibody; MTR1 antibody; Novel protein similar to vertebrate transient receptor potential cation channel, subfamily M, member 5 antibody; Transient receptor potential cation channel subfamily M member 5 antibody; Transient receptor potential cation channel, subfamily M, member 5 antibody; Trpm5 antibody; TRPM5 transient receptor potential cation channel, subfamily M, member 5 antibody; TRPM5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human TRPM5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
  • 基因功能參考文獻：
    1. genetic association studies in populations in Northern Europe, Maghreb, and Sri Lanka: Data suggest that SNPs in TAS2R50 (rs1376251), TRPM5 (rs800345), and TAS2R16 (rs860170) are associated with cultural food preferences; TAS2R16 (rs860170) strongly differentiates populations and is associated to salicin bitterness perception. (TAS2R = taste receptor type 2) PMID: 28366770
    2. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis PMID: 26546534
    3. The PKC-dependent effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores PMID: 26571400
    4. In a Turkish population, genetic polymorphism in TRPM5 genes modify individual susceptibility to metabolic syndrome. PMID: 25967713
    5. TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via an NCX to trigger MUC5AC secretion PMID: 23741618
    6. TrpM5 expression was similar throughout the olfactory glomeruli. PMID: 24288162
    7. The TRPM5 gene rs34551253 (Ala456Thr) polymorphism may be associated with increased risk of developing primary open angle glaucoma in the Turkish population. PMID: 24019741
    8. AZIN1 rs2679757 and TRPM5 rs886277 are associated with the risk of HBV-related liver cirrhosis in Chinese. PMID: 23844940
    9. extracellular Zn(2+) inhibits TRPM5 channels, and the residues in the outer pore loop of TRPM5 are critically involved in the inhibition. PMID: 23884414
    10. common TRPM5 variants are likely to be associated with prediabetic phenotypes; and this may in turn contribute to the development of type 2 diabetes mellitus PMID: 21489577
    11. results suggest TRPM5 may play a role in upregulating endogenous expression of TRPA1, that TRPA1 activation may be an additional trigger for co-expressed calcium-dependent ion channels such as TRPM5, and that TRPM5 may amplify responses to TRPA1 ligands PMID: 21133676
    12. TRPM5 gene is imprinted, with preferential expression from the paternal allele. PMID: 10607831
    13. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i PMID: 14634208
    14. regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system PMID: 14657398
    15. data show that extracellular acidification acts through specific residues on transient receptor potential cation channel, subfamily M(TRPM5) to block conduction through two distinct but related mechanisms PMID: 15731110
    16. understanding the structural basis for TRPM5 function will ultimately allow the design of pharmaceuticals to enhance or interfere with taste sensations--{REVIEW} PMID: 17217064

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM5 sub-subfamily
  • 組織特異性：
    Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive pa
  • 數據庫鏈接：

    HGNC: 14323

    OMIM: 604600

    KEGG: hsa:29850

    STRING: 9606.ENSP00000155858

    UniGene: Hs.272287



主站蜘蛛池模板： 欧美第一黄网免费网站| 蜜臀av性久久久久蜜臀aⅴ| 男女做爰猛烈叫床视频免费| 亚洲欧美日韩国产成人| 国产人妻大战黑人第1集| 人妻少妇无码专视频在线| 欧美日产国产精品| 欧美性猛交xxxx乱大交3| 欧美在线 | 亚洲| 国产精品性夜天天拍拍2021| 天天摸天天做天天添欧美| 国产女人乱人伦精品一区二区| 亚洲精品久久久久久一区二区| 国产成人亚洲综合精品| 色又黄又爽18禁免费网站| 国产真实老熟女无套内射| а√资源新版在线天堂 | 欧洲熟妇色xxxxx视频| 国产肉丝袜在线观看| 丰满熟妇被猛烈进入高清片| 久久久久久毛片免费播放| 精品国产你懂的在线观看| 男人狂躁进女人下面免费视频| 人人妻人人澡人人爽欧美二区| 国产一区二区在线影院| 亚洲熟少妇在线播放999| 亚洲成年轻人电影网站www| 国产成人免费视频| 东方aⅴ免费观看久久av| 免费人成又黄又爽的视频 | 国产精品爽爽久久久久久无码| 国产v在线在线观看视频免费 | 高大丰满熟妇丰满的大白屁股| av国産精品毛片一区二区网站| 亚洲人亚洲人成电影网站色| 国产sm调教折磨视频| 天天爱天天做天天做天天吃中文| 日本熟妇厨房xxxxx乱| 国产suv精品一区二区| 揉捏奶头高潮呻吟视频| 未满十八勿入午夜免费网站|