在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRPC4AP Antibody

  • 中文名稱:
    TRPC4AP兔多克隆抗體
  • 貨號:
    CSB-PA777153
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA777153(TRPC4AP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TRPC4AP
  • 別名:
    antibody; TRPC4AP antibody; Chromosome 20 open reading frame 188 antibody; Protein TAP1 antibody; Protein TRUSS antibody; Short transient receptor potential channel 4 associated protein antibody; Short transient receptor potential channel 4-associated protein antibody; TAP1 protein antibody; TNF receptor ubiquitous scaffolding/signaling protein antibody; TNF-receptor ubiquitous scaffolding/signaling protein antibody; TP4AP_HUMAN antibody; Transient receptor potential cation channel; subfamily C; member 4 associated protein antibody; Trp4 associated protein antibody; Trp4-associated protein antibody; Trpc4 associated protein antibody; Trpc4-associated protein antibody; TRPC4AP antibody; TRRP4AP antibody; TRUSS antibody; Tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human TRPC4AP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
  • 基因功能參考文獻:
    1. TRUSS is a novel substrate of E3 ligase Skp2. PMID: 26038816
    2. The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years. PMID: 19059308
    3. These findings suggest that TNF-R1, TRUSS, and TRPC4 augment Ca(2+) loading of endoplasmic reticulum Ca(2+) stores in the context of m1AchR stimulation PMID: 20458742
    4. TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus PMID: 20551172
    5. results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families PMID: 18449908

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, perinuclear region.
  • 數據庫鏈接:

    HGNC: 16181

    OMIM: 608430

    KEGG: hsa:26133

    STRING: 9606.ENSP00000252015

    UniGene: Hs.168073



主站蜘蛛池模板: 内射老阿姨1区2区3区4区| 在线偷着国产精选视频| 狠狠亚洲色一日本高清色| 国产无套粉嫩白浆在线观看| 国产人与zoxxxx另类| 少妇愉情理伦片高潮日本| 在线天堂资源www在线中文| 久青草国产97香蕉在线视频| 国产男女猛烈无遮挡免费视频| 国精产品999国精产| 精品婷婷色一区二区三区| 护士奶头又大又软又好摸| а√在线中文网新版地址在线| 日本japanese丰满白浆| 一二三四视频在线观看日本| 亚洲男人的天堂在线aⅴ视频| 精品久久久久久| 色哟哟网站在线观看| 天堂在线最新版www中文| 亚洲精品久久久久avwww潮水 | 人妻丰满熟妇无码区免费| 青乐娱精品视频一国产分类| 五月天精品视频在线观看| 欧美激情在线播放| 精品亚洲一区二区三区在线播放| 日本三级欧美三级人妇视频| 熟妇人妻中文字幕无码老熟妇| 国产农村乱对白刺激视频| 亚洲中文欧美在线视频| 国产精品人妻久久久久| xx性欧美肥妇精品久久久久久| 人妻少妇乱子伦无码专区| 亚洲成av人片高潮喷水| 国产午夜亚洲精品国产成人小说 | 成人午夜高潮免费视频在线观看| 久久精品中文字幕第一页| 无码成人一区二区| 久久精品女人天堂av麻| 国产亚洲精aa在线观看see| 亚洲中文字幕一区精品自拍| 欧美巨大黑人极品精男|