在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRIP13 Antibody

  • 中文名稱:
    TRIP13兔多克隆抗體
  • 貨號:
    CSB-PA623008LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623008LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA623008LA01HU at dilution of 1:100
    • Western blot
      All lanes: TRIP13 antibody at 1µg/ml + A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 49, 23 kDa
      Observed band size: 49 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TRIP13 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TRIP13
  • 別名:
    16E1-BP antibody; 16E1BP antibody; Homo sapiens HPV16 E1 protein binding protein mRNA complete cds antibody; HPV16 E1 protein binding protein antibody; HPV16 E1 protein-binding protein antibody; Human papillomavirus type 16 E1 protein binding protein antibody; Human papillomavirus type 16 E1 protein-binding protein antibody; Pachytene checkpoint protein 2 homolog antibody; PCH2 antibody; Thyroid hormone receptor interactor 13 antibody; Thyroid receptor interacting protein 13 antibody; Thyroid receptor-interacting protein 13 antibody; TR-interacting protein 13 antibody; TRIP-13 antibody; Trip13 antibody; TRP13_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Pachytene checkpoint protein 2 homolog protein (181-390AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,TRIP13 Antibody (CSB-PA623008LA01HU),的標記方式是Non-conjugated。對于TRIP13 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA623008LB01HU TRIP13 Antibody, HRP conjugated ELISA
    FITC CSB-PA623008LC01HU TRIP13 Antibody, FITC conjugated
    Biotin CSB-PA623008LD01HU TRIP13 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation.
  • 基因功能參考文獻:
    1. heightened TRIP13 expression appears to promote lung adenocarcinoma tumor progression. PMID: 29567476
    2. TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region. PMID: 29208896
    3. Microarray analyses indicated that the biological function of TRIP13 in CLL is majorly cell apoptosis and cell proliferation associated. TRIP13 siRNA expressing cells exhibited a slower cell proliferation rate and underwent apoptosis compared with control cells. PMID: 28424416
    4. TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM. PMID: 28157697
    5. These results identify an unexpected dependency on TRIP13 in cells overexpressing Mad2. PMID: 28564602
    6. 6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC impairment. PMID: 28553959
    7. Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP. PMID: 28659378
    8. These results establish a paradigm of the roles of p31(comet) and TRIP13 in both checkpoint activation and inactivation. PMID: 26832417
    9. the oligomeric form of TRIP13 binds both p31(comet) and MCC PMID: 26324890
    10. TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer. PMID: 25078033
    11. suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development PMID: 25012665
    12. propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation PMID: 25092294

    顯示更多

    收起更多

  • 相關疾病:
    Mosaic variegated aneuploidy syndrome 3 (MVA3)
  • 蛋白家族:
    AAA ATPase family, PCH2 subfamily
  • 數據庫鏈接:

    HGNC: 12307

    OMIM: 604507

    KEGG: hsa:9319

    STRING: 9606.ENSP00000166345

    UniGene: Hs.436187



主站蜘蛛池模板: 日本在线视频www色| 樱花草在线社区www日本影院| 精品无码日韩一区二区三区不卡 | 国产精品久久香蕉免费播放| 国产午夜无码片在线观看网站| 亚洲 日韩 国产欧美 另类| 日韩欧美群交p片內射中文| 麻豆精品久久久久久久99蜜桃| 久久精品丝袜高跟鞋| 日本丰满熟妇乱子伦| 国产午夜无码福利在线看网站| 成在线人视频免费视频| 国产 在线 | 日韩| 亚洲 欧美 另类 制服 日韩| 国产国产裸模裸模私拍视频| 国产成人免费视频| 亚洲性无码av中文字幕| 国产白丝精品爽爽久久久久久蜜臀| 伊人99综合精品视频| 97久久精品亚洲中文字幕无码| 色狠狠av一区二区三区| 99九九99九九视频精品| 肉体裸交137日本大胆摄影| 成年女人免费视频播放体验区| 未满十八18禁止免费无码网站| 99久久无色码中文字幕人妻| 中文字幕亚洲综合久久蜜桃| 亚洲欧美另类久久久精品| 欧美巨波霸乳影院| 丁香五月综合久久激情| 国产乱子伦精品无码码专区 | 永久免费无码国产| 色偷偷久久一区二区三区| 偷偷色噜狠狠狠狠的777米奇| 少妇厨房愉情理伦bd在线观看| 国产高清不卡免费视频| 亚洲人成伊人成综合网久久久| 国产情侣真实露脸在线| 亚洲综合在线视频自拍| 国产又黄又爽胸又大免费视频| 成人免费一区二区三区|