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  4. TRIM36 Antibody, Biotin conjugated

TRIM36 Antibody, Biotin conjugated

  • 中文名稱：
    TRIM36兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA868285LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TRIM36 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TRIM36
  • 別名：
    Acrosome RBCC protein antibody; E3 ubiquitin protein ligase TRIM36 antibody; E3 ubiquitin-protein ligase Trim36 antibody; Haprin antibody; RBCC728 antibody; RING finger protein 98 antibody; RNF98 antibody; TRI36_HUMAN antibody; TRIM 36 antibody; Trim36 antibody; Tripartite motif containing 36 antibody; Tripartite motif containing protein 36 antibody; Tripartite motif protein 36 antibody; Tripartite motif-containing protein 36 antibody; Zinc binding protein Rbcc728 antibody; Zinc-binding protein Rbcc728 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase TRIM36 protein (70-280AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
  • 基因功能參考文獻：
    1. aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure PMID: 28359976
    2. The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly . PMID: 28087737
    3. TRIM36 is the causative gene for autosomal recessive anencephaly PMID: 28087737
    4. The overexpression of the TRIM36 in the vast majority of prostate cancer suggest that this gene might be involved in the prostate tumorigenesis. PMID: 15145053
    5. molecular cloning and characterization of a human haprin ortholog. PMID: 15955891
    6. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H, potentially associated with chromosome segregation and its excess may cause chromosomal instability. PMID: 19232519

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  • 相關疾病：
    Anencephaly (ANPH)
  • 亞細胞定位：
    Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRIM/RBCC family
  • 組織特異性：
    Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. Expressed in fetal tissues.
  • 數據庫鏈接：

    HGNC: 16280

    OMIM: 206500

    KEGG: hsa:55521

    STRING: 9606.ENSP00000282369

    UniGene: Hs.519514



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