在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TRIM23 Antibody

TRIM23 Antibody

  • 中文名稱：
    TRIM23兔多克隆抗體
  • 貨號：
    CSB-PA024459ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: TRIM23 antibody at 4.55 μg/ml + Raw264.7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 65, 64, 62 kDa
      Observed band size: 65, 35 kDa
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA024459ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA024459ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TRIM23 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TRIM23
  • 別名：
    ADP ribosylation factor domain protein 1 antibody; ADP-ribosylation factor domain-containing protein 1 antibody; ARF domain protein 1 antibody; ARFD1 antibody; E3 ubiquitin-protein ligase TRIM23 antibody; GTP binding protein ARD 1 antibody; GTP-binding protein ARD-1 antibody; N-acetyltransferase ARD1 human homolog of antibody; N-acetyltransferase homolog of S. cerevisiae ARD1 antibody; RING finger protein 46 antibody; TRI23_HUMAN antibody; TRIM23 antibody; Tripartite motif protein TRIM23 antibody; Tripartite motif-containing protein 23 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase TRIM23 protein (1-280AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.; (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.
  • 基因功能參考文獻：
    1. TRIM23 may be associated with progression of gastric cancer PMID: 30477642
    2. work identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation PMID: 28871090
    3. Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM activation PMID: 28681414
    4. TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2. PMID: 25905670
    5. conclude that TRIM23-mediated ubiquitin conjugation to NEMO is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses PMID: 20724660
    6. Data are consistent with a potential function for ADP-ribosylation factor domain protein 1 as an E3 ubiquitin ligase in cells. PMID: 15684077
    7. The authors present a novel role for TRIM23 that is specific to UL144-mediated activation of NF-kappaB during the course of virus infection. PMID: 19176615

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.
  • 蛋白家族：
    Small GTPase superfamily, Arf family
  • 數據庫鏈接：

    HGNC: 660

    OMIM: 601747

    KEGG: hsa:373

    STRING: 9606.ENSP00000231524

    UniGene: Hs.792



主站蜘蛛池模板： 天下第一社区视频www日本| 无码东京热一区二区三区| 免费乱理伦片在线观看| 99久久国产成人免费网站| 伊人久久精品无码麻豆一区| 又大又紧又粉嫩18p少妇| 精品国产av一二三四区| 天堂中文最新版在线官网在线 | 国产高清视频在线观看69| 99这里有精品视频视频| 舌头伸进去搅动好爽视频| 国产精品h片在线播放| 国产成人无码视频一区二区三区| 各处沟厕大尺度偷拍女厕嘘嘘| 久久婷婷五月综合色和| 免费人成网视频在线观看| 欧美精品v欧洲精品| 欧美老妇人与禽交| 无码夜色一区二区三区| 国产精品老熟女露脸视频| 精品欧美аv高清免费视频| 亚洲中字慕日产2020| 亚洲国产区男人本色| 亚洲 欧美日韩 综合 国产| 狠狠人妻久久久久久综合| 久久综合97丁香色香蕉| 精品四虎国产在免费观看 | 天天做天天爱夜夜爽毛片毛片| 国产精品久久久影视青草| 久久久国产精品亚洲一区| 乱人伦无码中文视频在线| 欧美性猛交xxxx三人| 五月婷婷久久草丁香| 男女吃奶做爰猛烈紧视频| 国产精品高潮呻吟av久久小说| 国产真人作爱免费视频道歉| 国产裸体美女永久免费无遮挡| 亚洲国产成人久久精品大牛影视| 成人午夜看黄在线尤物成人| 久久无码精品一一区二区三区 | 成人无码精品免费视频在线观看|