在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRIM21 Antibody

  • 中文名稱:
    TRIM21兔多克隆抗體
  • 貨號:
    CSB-PA024457GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody; 52 kDa Ro protein antibody; 52kD Ro/SSA autoantigen antibody; Autoantigen Ro/SSA, 52-KD antibody; E3 ubiquitin-protein ligase TRIM21 antibody; RING finger protein 81 antibody; RNF81 antibody; Ro 52 antibody; Ro(SS-A) antibody; Ro52 antibody; RO52_HUMAN antibody; Sicca syndrome antigen A antibody; Sjoegren syndrome type A antigen antibody; Sjogren syndrome antigen A1 antibody; Sjogren syndrome type A antigen antibody; SS-A antibody; SSA antibody; SSA1: Sjogren syndrome antigen A1 (52kDa ribonucleoprotein autoantigen SS-A/Ro) antibody; TRIM21 antibody; Tripartite motif protein TRIM21 antibody; Tripartite motif-containing 21 antibody; Tripartite motif-containing protein 21 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TRIM21
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses. Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI.
  • 基因功能參考文獻:
    1. the TRIM21 knockdown increases SALL1 levels, indicating that TRIM21 degrades both SALL1 and SALL4. PMID: 29511085
    2. The expression of TRIM21 mRNA and protein was significantly higher in Systemic lupus erythematosus PBMCs as compared to healthy controls. There was a correlation between TRIM21 mRNA expression and Systemic lupus erythematosus activities. PMID: 29385873
    3. Low TRIM21 expression is associated with RNA virus infections. PMID: 29743353
    4. TRIM21 positively regulated osteosarcoma cell proliferation. Overexpression of TRIM21 enhanced osteosarcoma cell tolerance toward various stresses. YWHAZ protein was identified as a novel interacting partner of TRIM21 and its expression levels were negatively regulated by TRIM21. PMID: 29673441
    5. expression increased in lesional psoriatic skin PMID: 27943421
    6. when misfolded tau assemblies enter the cell, they can be detected and neutralized via a danger response mediated by tau-associated antibodies and the cytosolic Fc receptor tripartite motif protein 21 (TRIM21) PMID: 28049840
    7. Taken together, the current study provides evidence of new function of Ro60/SSA in the development of cancer. It facilitates pancreatic cancer proliferation, migration and invasion. Therefore, it may represent a novel molecular target for the management of pancreatic cancer. PMID: 29274781
    8. We suggest that TRIM21 may be one of the factors associated with the "switching on" the proinflammatory programme in CD16(+) monocytes or monocyte-derived macrophages. PMID: 27773663
    9. Authors demonstrate that TRIM21 expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer. PMID: 27830973
    10. TRIM21 role in TRAIL-induced apoptosis PMID: 27219672
    11. Our data suggest that patients with IIM, mainly DM, are characterized by a deficient expression of Ro52/TRIM21 in different PBMC subsets (CD4(+) lymphocytes and monocytes), along with lower K48-mediated ubiquitination, which is associated with a proinflammatory cytokine response. PMID: 27936488
    12. Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La . PMID: 26725021
    13. downregulation of miR-1207-5p and miR-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogren's syndrome PMID: 26888739
    14. The interaction of TRIM21 and LFG was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out. PMID: 26398169
    15. TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage. PMID: 26942676
    16. TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I PMID: 26506431
    17. we prove that TRIM21 is a potential tumor suppressor in hepatocellular carcinoma and its low expression indicates poor prognosis PMID: 26055142
    18. Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response PMID: 26342464
    19. TRIM20 and TRIM21 mediate precision autophagy, controlling the hub signaling machineries and key factors, inflammasome and type I interferon, directing cardinal innate immunity response systems in humans. PMID: 26347139
    20. This study elucidates a complex mechanism of step-wise ubiquitination and deubiquitination activities that allows contemporaneous innate immune signaling and neutralization by TRIM21. PMID: 26150489
    21. Anti-Ro52/TRIM21 antibodies are independently associated with the presence of interstitial lung disease and poor survival in systemic sclerosis. PMID: 26315678
    22. Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the SS-A and SS-B autoantigens in salivary gland epithelial cells of Sjogren's syndrome patients. PMID: 25845745
    23. These data extend the protective role of TRIM21 from viruses to bacteria and thereby strengthening the general role of antibody-dependent intracellular neutralisation in cellular immunity. PMID: 24920099
    24. Upregulation of SSA1 is associated with alcoholic and nonalcoholic steatohepatitis. PMID: 25526666
    25. TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms. PMID: 25084355
    26. Report association of Anti-Ro/SSA-p200 antibodies with congenital heart block. PMID: 25327946
    27. Although protein expression levels were not affected significantly, the late up-regulation of Ro52/TRIM21 mRNA was accompanied by protein redistribution PMID: 25098814
    28. the up-regulation of Ro52 in ductal epithelium might be a triggering factor for disease progression in Sjogren's syndrome. PMID: 24673429
    29. Cytoplasmic sequestration of GMPS requires ubiquitylation by TRIM21. PMID: 24462112
    30. epitope peptide of the TRIM21 (TRIM: tripartite motif) autoantigen that is recognized by a polyclonal antibody was determined as assembling an "L-E-Q-L" motif on an alpha-helix PMID: 24094071
    31. Regulation of TRIM-21 expression occurs through an ERalpha-dependent mechanism, a pathway that was observed to be overactive in SLE patients. PMID: 24449583
    32. Autoantibodies to the RING domain of Ro52 significantly correlate with disease activity in systemic lupus erythematosus. PMID: 23554036
    33. Our data demonstrate that multiple IRFs tightly regulate expression of Trim21 in immune cells. PMID: 23975864
    34. This retrospective study supports the routine distinction of anti-SSA/Ro60 and anti-Ro52/TRIM21 due to their different clinical associations. PMID: 23039326
    35. Anti-TRIM21 antibodies were the second most common autoantibodies in this systemic sclerosis cohort. PMID: 22394602
    36. Data suggest that the identification of the SS-A/Ro pattern at the ANA-HEp-2 screening routine shall lead to specific tests for the identification of anti-SS-A/Ro antibodies. PMID: 23357050
    37. Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. PMID: 23455675
    38. Anti-Ro52 antibodies were closely associated with the main clinical, histopathological and immunological features of primary Sjogren's syndrome. PMID: 22704838
    39. analysis of a novel role for tyrosine phosphorylation in regulating the interaction with IRF3 and the activity of TRIM21 downstream of TLR3 and TLR4 PMID: 22479513
    40. The direct interaction between TRIM21 and neutralizing antibody is essential, as single-point mutations within the TRIM21-binding site in the Fc region of a potently neutralizing antibody impair virus neutralization. PMID: 22647693
    41. data suggest that Ro52/SSA is involved in death receptor-mediated apoptosis by regulating c-FLIP(L) PMID: 22288650
    42. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity. PMID: 22178074
    43. anti-Ro52 autoantibodies binding the RING domain of Ro52 may be actively involved in the pathogenesis of rheumatic autoimmune disease by inhibiting Ro52-mediated ubiquitination. PMID: 21862588
    44. FADD and TRIM21 together negatively regulate the late IFN-alpha pathway in response to viral infection. PMID: 21183682
    45. 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity PMID: 20224770
    46. Cells possess a cytosolic IgG receptor, tripartite motif-containing 21 (TRIM21), which binds to antibodies with a higher affinity than any other IgG receptor in the human body. PMID: 21045130
    47. Results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. PMID: 20668674
    48. Ro52-mediated monoubiquitination is involved in the subcellular translocation of active IKK beta to autophagosomes. PMID: 20627395
    49. Importantly, the Ro52 cytoplasmic bodies are highly motile and are located along the microtubule network. These results suggest that the Ro52 cytoplasmic bodies are unidentified structures that are transported along the microtubule network. PMID: 20013343
    50. Ro52 down-regulates Tax-induced NF-kappaB signalling by monoubiquitinating IKKbeta and by reducing the level of Tax PMID: 19675099

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasmic vesicle, autophagosome. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called processing bodies (P-bodies) that are located underneath the plasma membrane and also diffusely in the cytoplasm. They are located along the microtubules and are highly motile in cells. Colocalizes with DCP2 in P-bodies.
  • 蛋白家族:
    TRIM/RBCC family
  • 組織特異性:
    Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
  • 數據庫鏈接:

    HGNC: 11312

    OMIM: 109092

    KEGG: hsa:6737

    STRING: 9606.ENSP00000254436

    UniGene: Hs.532357



主站蜘蛛池模板: 无码少妇精品一区二区免费动态 | 日韩无码电影| 欧美午夜精品久久久久久浪潮| 欧美高清精品一区二区| 中文字幕无码专区一va亚洲v专区在线 | 国产99爱在线视频免费观看| 4444亚洲人成无码网在线观看| 午夜精品久久久久久久| 337p人体粉嫩胞高清视频| 国产成人免费97在线观看| 亚洲综合无码中文字幕第2页| 免费看女人与公拘交酡过程| 国产福利姬喷水福利在线观看| 亚洲欧美日韩综合一区二区| 亚洲乱码中文字幕在线| 人妻少妇乱子伦无码专区| 亚洲欧美成人片在线观看| 中国老熟妇自拍hd发布| 特级西西人体444www高清大胆| 亚洲国产成人精品女人久久久| 老熟女毛茸茸浓毛| 国产成人啪精品视频免费网站软件| 免费人成网视频在线观看| 日本三级在线播放线观看视频 | 久久精品国产99国产精2020丨| 末发育娇小性色xxxxx| 国产精品人妻一码二码| 少妇人妻精品一区二区三区| 自拍偷在线精品自拍偷99| 日本wv一本一道久久香蕉| 男女爽爽无遮挡午夜视频| 又色又爽又高潮免费视频观看| 久久精品黄aa片一区二区三区| 欧美人与动牲交zooz男人| 人妻影音先锋啪啪av资源| 日本一卡二卡3卡四卡网站精品 | 69国产精品久久久久久人妻| 亚洲乱码国产乱码精品精| 亚洲欧洲日产国码在线| 色又黄又爽18禁免费网站| 精品亚洲aⅴ无码一区二区三区|