在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRIM14 Antibody

  • 中文名稱:
    TRIM14兔多克隆抗體
  • 貨號:
    CSB-PA024451GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    TRIM14
  • 別名:
    5830400N10Rik antibody; KIAA0129 antibody; pub antibody; TRI14_HUMAN antibody; TRIM14 antibody; tripartite motif protein 14 antibody; tripartite motif protein TRIM14 antibody; tripartite motif-containing 14 antibody; Tripartite motif-containing protein 14 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human TRIM14
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.
  • 基因功能參考文獻:
    1. Results showed that TRIM14 is increased in gastric cancer (GC) tissues and cell lines and associated with malignant features and unfavorable prognosis. Gain and lossoffunctional data confirmed that TRIM14 promotes migration, invasion and EMT progression by activating AKT signaling. TRIM14 was found to function as an oncogene in regulating EMT and metastasis of GC via AKT signaling, which was regulated by miR195. PMID: 30272351
    2. Our findings collectively suggest that TRIM14 functions as an oncogene by upregulating the AKT signaling pathway in osteosarcoma cells, supporting its potential utility as a therapeutic target for this disease. PMID: 28205534
    3. Study shows that tripartite Motif 14 (TRIM14) is a putative tumor suppressor and regulator of innate immune response in non-small cell lung cancer. The functional data establishes a novel tumor suppressive role for TRIM14 in non-small cell lung cancer progression. PMID: 28059079
    4. we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in oral squamous cell carcinoma is dependent on the interaction with TRIM14. PMID: 29204446
    5. In searching for mechanisms how TRIM14 exerts its antiviral function we found that TRIM14 interacted with HCV encoded non-structural protein NS5A and could strongly induce its degradation dependent on the NS5A1 subdomain. Interestingly extensive domain mapping analyses revealed that NS5A degradation was mediated by the highly conserved SPRY domain of TRIM14, which might involve the K48 ubiquitination pathway PMID: 27578425
    6. findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. PMID: 29053956
    7. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response PMID: 28476934
    8. survival of xenograft mice was prolonged by BsAbBmi/TRIM treatment compared to either AbBmi-1 or AbTRIM-14 treatment. In conclusion, these results provided new evidence that BsAbBmi/TRIM inhibited the progression of osteosarcoma, which suggest that BsAbBmi/TRIM may be a novel anti-cancer agent for osteosarcoma therapy PMID: 28631557
    9. MiR-15b degrades TRIM14 in oral tongue squamous cell cancer.TRIM14 role in oral tongue squamous cell cancer resistance to cisplatin. PMID: 28350138
    10. Data suggest that tripartite motif containing 14 protein (TRIM14) might play an important role in the malignant progression of tongue squamous cells carcinoma (TSCC) and in regulation of the NF_Kappa B (NF-kappaB) signaling pathway. PMID: 26799420
    11. stable enhanced expression of trim14 gene in cells activates the transcription of many immunity genes and suppresses Sindbis virus reproduction, but Sindbis virus infection of HEK-trim14 cells promotes inhibition of some genes involved in innate immunity. PMID: 25948474
    12. Upon virus infection, TRIM14 recruits NF-kappaB essential modulator (NEMO) to the MAVS complex via ubiquitin chains. PMID: 24379373

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion outer membrane. Cytoplasmic vesicle, phagosome.
  • 蛋白家族:
    TRIM/RBCC family
  • 組織特異性:
    Highest expression in liver; undetectable in skeletal muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16283

    OMIM: 606556

    KEGG: hsa:9830

    STRING: 9606.ENSP00000343990

    UniGene: Hs.575631



主站蜘蛛池模板: 女人高潮抽搐喷液30分钟视频| 亚洲精品少妇高清30p| 久久人妻夜夜做天天爽| 午夜男女很黄的视频| 精品一区二区三区在线观看视频| 亚洲 另类 在线 欧美 制服| 久久天天躁夜夜躁狠狠躁| 青青草免费国产线观720| √天堂8资源中文在线| 精品人妻少妇一区二区三区在线| 亚洲午夜无码极品久久| 2021精品亚洲中文字幕| 无套中出丰满人妻无码| 98国产精品综合一区二区三区 | 中文字幕丰满伦子无码| 国产无遮挡a片又黄又爽漫画| 久久综合伊人| 欧美成人一区二区三区在线视频 | 国产人妻xxxx精品hd| 国产精品久久久久高潮| 久久国产精品-国产精品| 成人爽a毛片免费网站| 在线观看精品视频网站| 中文精品久久久久人妻不卡| 亚洲中文字幕无码专区| 黄网站色视频免费观看| 国产v在线在线观看视频免费 | 国产免费一区二区三区在线观看| 日日躁夜夜躁狠狠躁超碰97| 欧洲美熟女乱又伦免费视频| 人摸人人人澡人人超碰97| 熟女少妇人妻中文字幕| 亚洲天堂2017无码中文| 97色伦97色伦国产欧美| 欧美三级午夜理伦三级| 青娱乐极品视觉盛宴国产视频| 久久www免费人成人片| 亚洲欧美中文日韩v在线97| 伊人久久大香线蕉av色婷婷色| 女人被做到高潮免费视频| 一本大道东京热无码视频|