在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRIM11 Antibody

  • 中文名稱:
    TRIM11兔多克隆抗體
  • 貨號:
    CSB-PA856931LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA856931LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TRIM11 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TRIM11
  • 別名:
    BIA 1 antibody; BIA1 antibody; E3 ubiquitin protein ligase TRIM11 antibody; E3 ubiquitin-protein ligase TRIM11 antibody; Protein BIA1 antibody; RING finger protein 92 antibody; RING type E3 ubiquitin transferase TRIM11 antibody; RNF 92 antibody; RNF92 antibody; TRI11_HUMAN antibody; Trim 11 antibody; TRIM11 antibody; Tripartite motif containing 11 antibody; tripartite motif protein 11 antibody; Tripartite motif-containing protein 11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase TRIM11 protein (267-468AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,TRIM11 Antibody (CSB-PA856931LA01HU),的標記方式是Non-conjugated。對于TRIM11 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA856931LB01HU TRIM11 Antibody, HRP conjugated ELISA
    FITC CSB-PA856931LC01HU TRIM11 Antibody, FITC conjugated
    Biotin CSB-PA856931LD01HU TRIM11 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
  • 基因功能參考文獻:
    1. findings identify TRIM11 as an important activator of the proteasome, define a pathway that adjusts proteasome activity, and reveal a mechanism by which tumor cells acquire higher degradative power to support oncogenic growth PMID: 29581427
    2. Data show that miR-24-3p downregulation contributes to tripartite motif-containing protein 11 (TRIM11) upregulation in cancer (CC). PMID: 27888625
    3. TRIM11 promotes the development and progression of HCC through regulating p53 and its downstream signals. PMID: 29190611
    4. data showed that tripartite motif-containing protein 11(TRIM11) expression was significantly elevated in hepatocellular carcinoma(HCC) tissues and overexpression of TRIM11 is closely associated with HCC progression and poor survival PMID: 28065743
    5. Results show that TRIM11 was highly expressed in lung cancer tissues and cell lines and suggest that it acts as an oncogene in lung cancer through promoting cell growth, migration and invasion. PMID: 27329103
    6. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy. PMID: 27498865
    7. TRIM11 to be overexpressed in HCC tissues and cell lines. Downregulation of TRIM11 inhibited HCC cell proliferation and invasion in vitro and in vivo as well as suppressed the epithelial-mesenchymal transition (EMT) process. PMID: 28244856
    8. study identified TRIM11 as a new HIV-1 capsid binding protein; data also reveal that TRIM11 restricts HIV-1 reverse transcription by accelerating viral uncoating, and microtubule dynamics is implicated in TRIM11-imposed block to early events of HIV-1 replication PMID: 27737691
    9. TRIM11 is a host cellular factor that interferes with the early steps of HIV-1 replication and provides a connection between viral protein and host antiviral factors. PMID: 25105968
    10. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth. PMID: 23178488
    11. TRIM11 negatively regulates IFN-beta production and antiviral activity by targeting TBK1. PMID: 23675467
    12. Study shows that the E3 ubiquitin ligase TRIM11 plays a critical role in the clearance of mutant PHOX2B, which causes congenital central hypoventilation syndrome, through the proteasome. PMID: 22307522
    13. PAX6 interacts with HOMER3, DNCL1, and TRIM11. Three C-terminal PAX6 mutations, previously identified in patients with eye malformations, all reduced or abolished the interactions. PMID: 16098226
    14. These results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling. PMID: 16904669
    15. Downregulation of TRIM11 and TRIM15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells. PMID: 18248090
    16. This study suggests a potential role for Trim11 in the specification of NA phenotype by interaction with Phox2b. PMID: 18275850

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    TRIM/RBCC family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 16281

    OMIM: 607868

    KEGG: hsa:81559

    STRING: 9606.ENSP00000284551

    UniGene: Hs.13543



主站蜘蛛池模板: av鲁丝一区鲁丝二区鲁丝三区| 精品国产福利在线视频| 亚洲精品国产高清在线观看| 亚洲精品久久久久久久蜜桃臀| 97精品国产一区二区三区| 国产一区二区三区四区五区vm| 久久人妻国产精品| 四虎影库久免费视频| 一区二区三区在线 | 欧洲| 狠狠色综合网久久久久久| 国产精品人成在线播放新网站| 精品国产电影久久九九| 青青草大香焦在线综合视频| 欧美国产日韩a在线视频| 国产沙发午睡系列999| 欧美亚洲日韩不卡在线在线观看| 免费无码又爽又高潮视频| 乱中年女人伦av| 极品粉嫩福利午夜在线播放| 国产成人青青久久大片| 婷婷综合另类小说色区| 日本一二免费不卡区| 国产亚洲欧美日韩夜色凹凸成人| 学生妹无套内射正在播放| 免费无码又爽又刺激激情视频软件| 高潮毛片无遮挡高清免费| 97夜夜澡人人爽人人喊a| 高清国产亚洲欧洲av综合一区 | 天美传媒精品1区2区3区| 欧美日韩国产中文高清视频 | 免费无码午夜福利片| 亚洲精品成人av观看| 毛片免费视频| 久久久久久久无码高潮| 无码任你躁久久久久久老妇蜜桃| 无码中文字幕乱在线观看| 国产精品ⅴ无码大片在线看 | 久久久久青草线蕉亚洲麻豆| 久久九九国产精品怡红院| 中文字幕日产无码| 人人妻人人澡人人爽人人精品97|