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  4. TRERF1 Antibody

TRERF1 Antibody

  • 中文名稱：
    TRERF1兔多克隆抗體
  • 貨號：
    CSB-PA030253
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TRERF1
  • 別名：
    TRERF1 antibody; BCAR2 antibody; RAPA antibody; TREP132 antibody; Transcriptional-regulating factor 1 antibody; Breast cancer anti-estrogen resistance 2 antibody; Transcriptional-regulating protein 132 antibody; Zinc finger protein rapa antibody; Zinc finger transcription factor TReP-132 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human TReP-132.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.
  • 基因功能參考文獻：
    1. the present study was the first to identify 2 novel, potentially 'diseasecausing' TRERF1 somatic mutations in the endometriotic lesions in 2 out of 92 patients with ovarian endometriosis; therefore, TRERF1 mutations may be involved in the pathogenesis of ovarian endometriosis. PMID: 29393434
    2. TReP-132 plays a role in regulating p450scc expression with steroidogenic factor-1 and CBP/p300 PMID: 12101186
    3. TReP-132 interacts with steroidogenic factor-1 (SF-1) through specific domains; and along with the interaction with CBP/p300 these factors are postulated to form a complex to regulate expression of the P450scc gene. PMID: 12530663
    4. TReP-132 is a trans-acting factor of genes involved in adrenal glucocorticoid, C(19) steroid and estrogen production. PMID: 15072559
    5. TReP-132 is a basal cell cycle regulatory protein interacting with Sp1 to activate the p21 and p27 gene promoters. PMID: 15899840
    6. identify TReP-132 as a coactivator of progesterone receptor mediating the growth-inhibitory and differentiation effects of progesterone on breast cancer cells PMID: 17015480

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells.
  • 數據庫鏈接：

    HGNC: 18273

    OMIM: 610322

    KEGG: hsa:55809

    STRING: 9606.ENSP00000362013

    UniGene: Hs.485392



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