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  4. TREML2 Antibody, Biotin conjugated

TREML2 Antibody, Biotin conjugated

  • 中文名稱：
    TREML2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA729201LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TREML2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    TREML2 antibody; C6orf76 antibody; TLT2 antibody; UNQ6268/PRO20473 antibody; Trem-like transcript 2 protein antibody; TLT-2 antibody; Triggering receptor expressed on myeloid cells-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Trem-like transcript 2 protein (19-268AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
  • 基因功能參考文獻：
    1. Mutation of TREML2 is a major factor leading to ankylosing spondylitis for HLA-B27 (+) members in a large family and that TREML2 is also a susceptibility gene promoting the development of ankylosing spondylitis in HLA-B27 (+) individuals. PMID: 29778423
    2. A missense variant in TREML2 was associated with a reduced risk of Alzheimer's Disease in a Han Chinese population. PMID: 26797517
    3. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
    4. Missense variant in TREML2 protects against Alzheimer's disease. PMID: 24439484
    5. TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation. PMID: 16670310
    6. analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation PMID: 18650384
    7. Data do not point to a role for TREML2 as a receptor for B7-H3. PMID: 19544488

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
  • 數據庫鏈接：

    HGNC: 21092

    OMIM: 609715

    KEGG: hsa:79865

    STRING: 9606.ENSP00000418767

    UniGene: Hs.164797



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