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TRAF7 Antibody, Biotin conjugated

  • 中文名稱:
    TRAF7兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA757671LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TRAF7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TRAF7
  • 別名:
    E3 ubiquitin protein ligase TRAF7 antibody; E3 ubiquitin-protein ligase TRAF7 antibody; RFWD1 antibody; Ring finger and WD repeat domain 1 antibody; RING finger and WD repeat-containing protein 1 antibody; RING finger protein 119 antibody; RNF119 antibody; TNF receptor associated factor 7 antibody; TNF receptor-associated factor 7 antibody; TRAF7 antibody; TRAF7_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase TRAF7 protein (1-90AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
  • 基因功能參考文獻:
    1. TRAF7 mutations icause intraneural perineuriomas. PMID: 28019650
    2. TRAF7 is a direct target of miR-126 in human umbilical cord vascular endothelial cells. PMID: 25318608
    3. Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer. PMID: 23128672
    4. The findings of this study suggested an essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 meningiomas. PMID: 23404370
    5. Nearly one-fourth of all meningiomas have mutations in TRAF7. PMID: 23348505
    6. TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB transcription factor. PMID: 22105767
    7. an important role for TRAF7 in the activation of JNK following TNFalpha stimulation and involvement of this protein in regulating the turnover of c-FLIP PMID: 22219201
    8. this study identifies TRAF7 as a NEMO- and p65-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB transcriptional activity. PMID: 21518757
    9. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis PMID: 15001576

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  • 亞細胞定位:
    Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
  • 蛋白家族:
    WD repeat TRAF7 family
  • 組織特異性:
    Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
  • 數據庫鏈接:

    HGNC: 20456

    OMIM: 606692

    KEGG: hsa:84231

    STRING: 9606.ENSP00000318944

    UniGene: Hs.713632



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