在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TP53INP1 Antibody, HRP conjugated

  • 中文名稱:
    TP53INP1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA822174LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TP53INP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TP53INP1
  • 別名:
    DKFZp434M1317 antibody; FLJ22139 antibody; p53 damage inducible nuclear protein 1 antibody; p53 dependent damage inducible nuclear protein 1 antibody; p53 inducible nuclear protein 1 antibody; p53 inducible p53DINP1 antibody; p53-dependent damage-inducible nuclear protein 1 antibody; p53DINP1 antibody; SIP antibody; Stress induced protein antibody; Stress-induced protein antibody; T53I1_HUMAN antibody; Teap antibody; TP53 DINP1 antibody; TP53 INP1 antibody; TP53DINP1 antibody; TP53INP1 antibody; TP53INP1A antibody; TP53INP1B antibody; Tumor protein p53 inducible nuclear protein 1 antibody; Tumor protein p53-inducible nuclear protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
  • 基因功能參考文獻:
    1. Upregulated miR-200a enhances treatment resistance via antagonizing TP53INP1 and YAP1 in breast cancer. PMID: 29329575
    2. these results revealed that TP53INP1 is a target gene of miR-504 and that miR-504 enhances osteosarcoma growth and promotes distant metastases by targeting TP53INP1. Thus, miR-504/TP53INP1 may be associated with osteosarcoma size and clinical stage. PMID: 29048685
    3. Low TP53INP1 expression is associated with Metastasis of Hepatocellular Carcinoma. PMID: 28674078
    4. Negative TP53INP1 protein levels correlated with a poor outcome in pediatric ependymoma. Direct binding of miR-124-3p to its target TP53INP1 is demonstrated. PMID: 28437838
    5. Results showed that TP53INP1 and E-cadherin mRNA and protein were significantly down-regulated in glioma tumors and positively correlated with higher grade and poor survival. Also, the study provides evidence that TP53INP1 3'-UTR could inhibit the epithelial-mesenchymal transition, thus hindering the migration and invasion of glioma via acting as a competitive endogenous RNA for E-cadherin. PMID: 27341836
    6. miR-205/TP53INP1 mediated autophagy pathway might be an important molecular mechanism regulating radiosensitivity of prostate cancer cells PMID: 26813458
    7. silencing of TP53inp1 leads radiation induced autophagy impairment and induces accumulation of damaged mitochondria in primary human fibroblasts. PMID: 26512655
    8. MicroRNA205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting TP53INP1 protein. PMID: 26252115
    9. FOXP1, TP53INP1, TNFAIP3, and TUSC2 were identified as miR-19a targets. PMID: 26367773
    10. GWAS identifies TP53INP1 as new susceptibility gene for Alzheimer's disease. PMID: 24922517
    11. TP53INP1 SUMOylation is essential for the regulation of p53 activity induced by oxidative stress. PMID: 24608790
    12. TGFB1 induced miR-155 regulates TP53INP1 expression, epithelial-mesenchymal transition and acquisition of a stem cell phenotype. PMID: 25633840
    13. miR-155 may play an important role in promoting the generation of stem cell-like cells and their self-renewal by targeting the gene TP53INP1. PMID: 25601564
    14. Results demonstrate that miR-569 is overexpressed in a subset of ovarian and breast cancers and alters cell survival and proliferation through downregulation of TP53INP1 expression. PMID: 25490449
    15. Study reveals that miR-155 acts as an oncogene by targeting TP53INP1 in esophageal squamous cell carcinoma. PMID: 24551280
    16. Expression of miR-155 is significantly higher in MCF-7 cells compared with MDA-MB-231 cells. Ectopic expression of TP53INP1 inhibits growth of MCF-7 cells by inducing cell apoptosis and inhibiting cell cycle progression. PMID: 24152184
    17. miR-182/TP53INP1 signaling represents a novel pathway regulating chemoresistance in cisplatin-treated hepatocellular carcinoma PMID: 24447717
    18. Upregulation of miR-155, mediated by estradiol, and consequent downregulation of TP53INP1 potentially promotes breast cancer development and progression. PMID: 23568502
    19. Fndings indicate that miR-17-5p/20a promote gastric cancer cell proliferation and inhibit cell apoptosis via post-transcriptional modulation of p21 and TP53INP1. PMID: 23333058
    20. miR-17-5p functions as a tumor suppressor in cervical cancer cells by targeting tumor protein p53-induced nuclear protein 1. PMID: 22730212
    21. TP53INP1 antisense oligonucleotide inhibits proliferation and induces apoptosis in castration-sensitive LNCaP tumor cells. PMID: 22213058
    22. TP53INP1 identified two conserved regions in the DOR family that concentrate multiple functions crucial for autophagy and transcription. PMID: 22470510
    23. In normal prostate tissues, TP53INP1 is only expressed in prostate basal cells. There is a de novo TP53INP1 expression in prostate luminal cells in inflammatory prostate tissues, high grade PIN lesions and in prostate cancer. PMID: 21538421
    24. This novel TP53INP1 activity on the regulation of SPARC expression could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process PMID: 21339733
    25. TP53INP1 is a tumor suppressor in esophageal squamous cell carcinoma (ESCC0; c-Myc-mediated DNA methylation-associated silencing of TP53INP1 contributed to the pathogenesis of human ESCC. PMID: 21219856
    26. Data show that induction of the stress-induced proteins (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is absent from cells with deleted, mutated or inactive p53, suggesting that regulation of SIP gene expression is dependent on p53. PMID: 12067065
    27. Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. PMID: 12438758
    28. TP53INP1s and HIPK2 could be partners in regulating p53 activity. PMID: 12851404
    29. TP53INP1s are functionally associated with p73 to regulate cell cycle progression and apoptosis. PMID: 16044147
    30. TP53INP1 protein negativity is significantly associated with aggressive pathological phenotypes of gastric cancer. PMID: 16521180
    31. TP531NP1 plays a significant role in the progression of anaplastic carcinoma or contributes to anaplastic transformation from papillary or follicular carcinoma, which is in sharp contrast to findings in previous in vitro and in vivo studies. PMID: 17393983
    32. PLZF upregulates apoptosis-inducer TP53INP1, ID1, and ID3 genes, and downregulates the apoptosis-inhibitor TERT gene PMID: 17537403
    33. The p53DINP1 mRna expression in the antral mucosa was significantly lower in the gastric cancer patients than in the chronic gastritis patients. PMID: 18277906
    34. P53DINP1 mRNA expression promotes Ser46 phophlrylation of p53, without finding a significant correlation between mRNA expression of p53AIP1. PMID: 18277909
    35. findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells PMID: 18974142

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 18022

    OMIM: 606185

    KEGG: hsa:94241

    STRING: 9606.ENSP00000344215

    UniGene: Hs.492261



主站蜘蛛池模板: 午夜精品影视国产一区在线麻豆| 国产亚洲精品欧洲在线视频| 日本欧美一区二区免费视频| 亚洲乱码中文字幕小综合| 一区二区三区内射美女毛片| 97免费人妻无码视频| 亚洲欧美日韩二三区在线| 免费国产黄网站在线观看可以下载| 国产精品美女久久久久av超清| 99久久国产露脸国语对白| 欧美成人综合久久精品| 欧美国产日韩a欧美在线观看 | 99久久人妻精品免费二区| 国产mv在线天堂mv免费观看| 国产亚洲视频在线观看网址| 欧美噜噜久久久xxx| 我的公把我弄高潮了视频| 久久五十路丰满熟女中出| 国产丰满人妻一区二区| 少妇激情一区二区三区视频小说| 插一插射一射视频| 九九久久精品国产av片国产| 丝袜高跟麻麻浓精受孕人妻| 青青草国产免费国产是公开| 51国产偷自视频区视频| 在线精品一区二区三区| 中国少妇初尝黑人巨高清| 免费的av网站手机版| 夜夜爽妓女8888视频免费观看| 女人被男人桶30分钟无遮挡动态图| 久久无码精品一一区二区三区 | 麻豆精品偷拍人妻在线网址| 亚洲色成人网站www永久| 老湿机69福利区无码| 日日天日日夜日日摸| 免费无码又爽又刺激聊天app| 97久久综合区小说区图片区| 九九久久精品免费观看| 国产一区二区丝袜高跟鞋| 欧美一进一出抽搐大尺度视频| 亚洲久热中文字幕在线|