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TP53AIP1 Antibody

  • 中文名稱:
    TP53AIP1兔多克隆抗體
  • 貨號:
    CSB-PA046843
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemistry analysis of paraffin-embedded human thymus gland tissue using TPIP1 antibody.
    • Immunofluorescence analysis of A549 cells, using TPIP1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TP53AIP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human TPIP1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play an important role in mediating p53/TP53-dependent apoptosis.
  • 基因功能參考文獻:
    1. results show that constitutional truncating TP53AIP1 mutations predispose to CMM in the French population PMID: 29359367
    2. Data indicate that p53-regulated apoptosis-inducing protein 1 (p53AIP1) inhibits the proliferation of PC-3M cells, arrests cell cycle at S/G2-M phase, decreases the abilities of invasion and migration and promotes cell apoptosis. PMID: 25108434
    3. These studies indicate the critical role of p53AIP1 under DNA damaging stresses for cell fate determination in rheumatoid arthritis-fibroblast-like synovioctes containing the p53R248Q mutation. PMID: 24316591
    4. Apak competes with p53 for binding to inhibit p53AIP1 expression. PMID: 22334068
    5. large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition PMID: 22457820
    6. p53AIP1 regulates the mitochondrial apoptotic pathway. PMID: 12019168
    7. The expression of Ki67 and p53 in various forms of leukoplakia point to the increasing instability of the genome in parallel with the severity of leukoplakia. PMID: 14707453
    8. expression of the p53 mutant, R248Q, in liver cancer cells may enhance their drug resistance and upregulation of P-glycoprotein activity may contribute to this protective effect. PMID: 15004724
    9. Roscovitine induced up-regulation of p53AIP1 protein and the depolarization of mitochondrial potential. PMID: 15657359
    10. p53AIP1 gene is important for non-small cell lung cancer progression and may be a possible prognostic marker PMID: 17851056
    11. Insufficient expression of p53AIP1 may play a role in gastric carcinogenesis in patients infected with H. pylori infection. PMID: 18277906
    12. Data suggest that the combination of p53AIP1 and survivin gene expression may be a powerful tool to stratify subgroups with better or worse prognosis from the variable non-small cell lung cancer population. PMID: 19228369

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  • 亞細胞定位:
    Mitochondrion.
  • 組織特異性:
    Only found to be expressed in thymus.
  • 數據庫鏈接:

    HGNC: 29984

    OMIM: 605426

    KEGG: hsa:63970

    STRING: 9606.ENSP00000432743

    UniGene: Hs.160953



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