在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TOP3B Antibody

TOP3B Antibody

  • 中文名稱：
    TOP3B兔多克隆抗體
  • 貨號：
    CSB-PA004316
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using Topo IIIβ-1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TOP3B
  • 別名：
    DNA topoisomerase 3 beta 1 antibody; DNA topoisomerase 3-beta-1 antibody; DNA topoisomerase III beta 1 antibody; DNA topoisomerase III beta-1 antibody; FLJ39376 antibody; TOP 3B antibody; TOP3B antibody; TOP3B_HUMAN antibody; TOP3B1 antibody; Topo III beta antibody; Topoisomerase (DNA) III beta antibody; Topoisomerase DNA III beta antibody; Topoisomerase III beta antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Topo IIIβ-1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Possesses negatively supercoiled DNA relaxing activity.
  • 基因功能參考文獻：
    1. Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported. PMID: 28176834
    2. Results identified TOP3B gene deletion as candidate gene in the etiology of neurodevelopmental disorders including juvenile myoclonic epilepsy. PMID: 29490292
    3. Top3beta mutants lacking either its RNA-binding domain or catalytic residue fail to promote synapse formation, suggesting that Top3beta requires both its mRNA-binding and catalytic activity to facilitate neurodevelopment. PMID: 28039324
    4. Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast. PMID: 27257063
    5. TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations. PMID: 24507716
    6. Topoisomerase IIIbeta expression can be a useful marker in assessing the prognosis of patients with breast cancer and is an independent predictor of survival. PMID: 20950730
    7. the positive regulatory region including the 5'GGAACC3' core element is essential for efficient expression of the DNA topoisomerase III beta gene PMID: 15358519
    8. Two isoforms of human DNA topoisomerase IIIbeta were expressed in HeLa cells. Isoform 1 was localized to the nucleus and associated with chromosomes during metaphase and anaphase. Isoform 2 was found in the cytoplasm. PMID: 11549288

    顯示更多

    收起更多

  • 蛋白家族：
    Type IA topoisomerase family
  • 組織特異性：
    Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 11993

    OMIM: 603582

    KEGG: hsa:8940

    STRING: 9606.ENSP00000349705

    UniGene: Hs.436401



主站蜘蛛池模板： 亚洲午夜无码久久久久蜜臀av| 亚洲乱码一区二区三区在线观看| 少妇系列之白嫩人妻| 久久综合久久鬼色| 麻豆国产人妻欲求不满| 最近日本精品一卡2卡3卡4卡| 免费观看成人毛片a片| 男阳茎进女阳道视频大全 | 国产亚洲精品自在久久| 无码人妻精品一区二| 成人麻豆日韩在无码视频| 全部露出来毛走秀福利视频| 女人被爽到高潮视频免费国产| 国产成人无码一区二区三区在线| 日本少妇高潮喷水视频| 国产欧美综合在线观看第十页 | 男人女人做爽爽18禁网站| 国产成人无码a区视频在线观看| 色护士极品影院| 天天做av天天爱天天爽| 无码乱肉视频免费大全合集| 国产人妖xxxx做受视频| 激情偷乱人成视频在线观看| 国产成人a∨麻豆精品| 久久精品人人做人人爽| 亚在线观看免费视频入口| 国产线观看免费观看| 亚洲愉拍自拍另类图片| 狠狠色综合激情丁香五月| 成人无遮羞视频在线观看| 成人免费午夜无码视频在线播放| 成人爽a毛片在线视频| 丁香激情综合久久伊人久久| 无码高潮又爽又黄a片软件| 又爽又黄无遮挡高潮视频网站| 人妻巨大乳hd免费看| 色老久久精品偷偷鲁| 西西人体大胆扒开下部337卩| 日韩av片无码一区二区不卡电影 | 综合色区国产亚洲另类| 亚洲国产成人久久综合|