在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TOMM70A Antibody

  • 中文名稱:
    TOMM70A兔多克隆抗體
  • 貨號(hào):
    CSB-PA024055GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    TOMM70; KIAA0719; TOM70; TOMM70A; Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TOM70
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis.
  • 基因功能參考文獻(xiàn):
    1. Collectively, this study characterizes a novel protein complex, Tom70/Hsp90/IRF3/Bax, that is important for Sendai virus-induced apoptosis. PMID: 25609812
    2. Tom70 acts as a molecular switch that orchestrates hypertrophic stresses and mitochondrial responses to determine pathological cardiac hypertrophy. PMID: 25022898
    3. Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery. PMID: 24149440
    4. PINK1 is imported into mitochondria by a unique pathway that is independent of the TOM core complex but crucially depends on the import receptor Tom70 PMID: 23472196
    5. The hepatitis C virus NS3/4A protein induced Tom70 expression. PMID: 22032846
    6. used biophysical tools to study the interaction between the C-terminal domain of Hsp90 (C-Hsp90), which contains the EEVD motif that binds to TPR domains, and the cytosolic fragment of Tom70 PMID: 21781956
    7. This study revealed a novel finding, that is, human TOM70 is linked with the hepatitis C virus NS3 protein and the apoptotic response. PMID: 21412788
    8. Tom70 as a critical adaptor linking MAVS to TBK1/IRF3, revealing that mitochondrion is evolutionarily integrated with innate immunity. PMID: 20628368
    9. results indicate that the Tom70 monomers are the functional form of the receptor, whereas the homodimers appear to be a minor population, and may represent an inactive state PMID: 20504278
    10. TOMM70A is ubiquitously expressed in human tissues, maps on chromosome 3q13.1-q13.2 and consists of 12 coding exons spanning over 37 kb. PMID: 12200962
    11. The internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway. PMID: 16822835
    12. suggests a novel active role for Hsp90 in import steps subsequent to Tom70 targeting. PMID: 16968702
    13. S100A2 and S100A6 interact with another TPR protein Tom70 and regulate the Tom70-ligand interaction in vitro PMID: 18669640
    14. nuclear respiratory factor-2 binding site methylation suppresses the promoter activity of the human TOMM70 gene PMID: 18852034

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion outer membrane; Single-pass membrane protein.
  • 蛋白家族:
    Tom70 family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11985

    OMIM: 606081

    KEGG: hsa:9868

    STRING: 9606.ENSP00000284320

    UniGene: Hs.227253



主站蜘蛛池模板: 狠狠做深爱婷婷久久综合一区 | 久久青草费线频观看| 国产精品亚洲一区二区三区| 99精品热在线在线观看视频| 99热久久精里都是精品6| 小鲜肉自慰网站| 日本japanese丰满白浆| 真人做人60分钟啪啪免费看| 欧美老肥妇多毛xxxxx| 中文字幕美人妻亅u乚一596| 日韩国产丝袜人妻一二区| 午夜伦4480yy私人影院| 久久天天躁狠狠躁夜夜躁app| 沈阳45老熟女高潮喷水亮点| 国产亚洲精品久久久ai换| 日韩高清成片免费视频| 2019最新中文字幕在线观看| 大又大粗又爽又黄少妇毛片| 午夜高清在线无码| 337p日本大胆欧美裸体艺术| 女女女女女裸体处开bbb| 女人18片毛片60分钟| 男女性潮高清免费网站| 亚洲国产精品一区二区制服| 国产精品盗摄!偷窥盗摄| 蜜桃一区二区三区| 中文无码伦av中文字幕在线| 亚洲自偷自拍另类11p| 麻豆av福利av久久av| 成人区精品一区二区不卡| 人妻性奴波多野结衣无码| 水蜜桃亚洲一二三四在线| 久99久无码精品视频免费播放| 亚洲国产精品第一区二区三区| 无码一区二区三区久久精品| 国产尤物精品视频| 国产精品无码2021在线观看| 午夜无码国产理论在线| 亚洲一区二区三区成人网站| 人人玩人人添人人澡| 欧美激欧美啪啪片|