在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TOMM40 Antibody

  • 中文名稱:
    TOMM40兔多克隆抗體
  • 貨號:
    CSB-PA024050GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TOMM40
  • 別名:
    C19orf1 antibody; D19S1177E antibody; Haymaker protein antibody; Mitochondrial import receptor subunit TOM40 homolog antibody; Mitochondrial outer membrane protein antibody; Mitochondrial outer membrane protein TOM40 antibody; p38.5 antibody; PER EC1 antibody; PEREC1 antibody; Probable mitochondrial import receptor subunit TOM40 homolog antibody; Protein Haymaker antibody; TOM40 antibody; TOM40_HUMAN antibody; TOMM40 antibody; Translocase of outer membrane 40 kDa subunit homolog antibody; Translocase of outer mitochondrial membrane 40 antibody; Translocase of outer mitochondrial membrane 40 homolog (yeast) antibody; Translocase of outer mitochondrial membrane 40 homolog antibody; Translocase of outer mitochondrial membrane 40, yeast, homolog of antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TOMM40
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria.
  • 基因功能參考文獻:
    1. TOM40 over-expression blocked Ab-elicited decreases in the mitochondrial membrane potential, cellular ATP levels, and cellular viability in the control cells. These data suggest elevated expression of TOM40 may be protective of mitochondrial function. PMID: 28768149
    2. PPARgamma knockdown resulted in increased levels of TOMM40, APOE and APOC1 -mRNAs, showing the strongest impact on APOE transcript levels. PMID: 28065845
    3. Results from this exploratory analysis suggest that regulatory element methylation levels within the larger TOMM40-APOE-APOC2 gene region correlate with AD-related biomarkers and TOMM40 or APOE gene expression in AD. PMID: 29371683
    4. This study demonstrated that the association of TOMM40 '523-L with cognitive decline is primarily mediated by common neuropathologies. By contrast, the association of TOMM40 '523-S/S is relatively independent of these pathologies. PMID: 28624335
    5. This study found in middle-aged and aged cohorts that FH altered TOMM40 '523 poly-T genotype associations on memory, and additionally in aged participants for both global decline and cognitive impairment risk. PMID: 28549947
    6. Our data provide support for TOMM40 variant repeat length as an important contributor to AD-like Medial Temporal Lobe pathology in the absence of APOE epsilon4. PMID: 28183529
    7. Survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele. The age of disease onset is earlier if APOE4/4 is present in the Colombian population studied. PMID: 27023435
    8. report association of APOE and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 with progressive non-fluent aphasia. PMID: 28387812
    9. Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40], rs4420638 [APOC1], and rs429358 [APOE]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise PMID: 27707806
    10. Each epsilon4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 '523-L PMID: 28672022
    11. meta-analysis to investigate the association between rs2075650 polymorphism and Alzheimer's disease (AD) in Asian, Caucasian, and mixed populations; analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations PMID: 27328316
    12. Results reveal an association of APOE epsilon3/3-TOMM40'523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory. PMID: 28108637
    13. These findings indicated that variants in TOMM40/APOE/APOC1 region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity. PMID: 26657933
    14. Our results do not support the notion that TOMM40 poly-T repeat variants have independent effects on Parkinson's disease with dementia and Dementia with Lewy bodies pathology PMID: 26756745
    15. rs2075650 polymorphism in TOMM40 gene may increase the risk of Alzheimer disease. PMID: 26572157
    16. investigate the influence of the TOMM40 intron 6 poly-T variant (rs10524523) on TOMM40 gene expression and cognitive abilities and decline in a cohort of 1613 community-dwelling elderly volunteers PMID: 26742953
    17. rs2075650 at intron region TOMM40 is associated with the A beta-42 levels in CSF. PMID: 26576771
    18. No significant effects of APOE epsilon or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants PMID: 26310205
    19. Epilepsy, impaired fine motor function and gastrostomy tube feeding were less common in cerebral palsy children with single nucleotide polymorphisms in the APOE or TOMM40 genes PMID: 25703783
    20. Its variants are related to impairment in allocentric spatial navigation and reduced cortical thickness of specific brain regions among aMCI individuals with (LOAD neutral) APOE epsilon3/epsilon3 genotype. PMID: 25862420
    21. TOMM40 VL polyT repeat, although not influencing disease susceptibility, has a disease-modifying effect on sIBM, which can be enhanced by the APOE genotype epsilon3/epsilon3. PMID: 25670332
    22. This study show genome-wide significant SNP-based associations within three genomic regions 6q16.1 (MIR2113), 14q12 (AKAP6/NPAS3 region) and 19q13.32 (TOMM40/APOE region) with cognition. PMID: 25644384
    23. Elevated levels of TOMM40 and APOE transcripts found in the brains of late-onset Alzheimer's disease-affected individuals compared with unaffected control brains PMID: 24439168
    24. PVRL2, TOMM40 and APOE might be associated with human longevity. PMID: 24924924
    25. The results of this study suggested that previous findings of an association of the TOMM40 short allele with better cognitive performance, independently from the APOE variant status, are pertinent to elderly with diabetes. PMID: 25044051
    26. Two genetic risk factors for late onset Alzheimer's disease are in the apolipoprotein-e and translocase of outer mitochondrial membrane 40 (TOMM40) gene poly-T repeat loci. PMID: 25247594
    27. Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity. PMID: 25140902
    28. The findings of this study consistently lower TOMM40 expression on longitudinal 2-year sampling support its potential role as a diagnostic blood AD biomarker. PMID: 25201778
    29. The present study shows for the first time that TOMM40 rs157581 polymorphism may modulate regional spontaneous brain activity and related to the progression of amnestic mild cognitive impairment. PMID: 24838536
    30. study did not confirm the impact of rs2075650 on advanced AMD risk, indicating that rs2075650 is unlikely a superior marker for APOE/TOMM40 susceptible region with advanced AMD in Han Chinese population. PMID: 25304313
    31. It was discovered that polymorphic variants of TOMM40 rs741780, rs1160985, and rs8106922 are associated with serum triglyceride concentrations. PMID: 25711031
    32. This study development of depression characterized by reduced extraversion, impaired executive function, and decreased positive emotional recall, and reduced top-down cortical control during sad emotion processing. PMID: 24549102
    33. It is an Alzheimer-disease susceptibility gene. PMID: 24508314
    34. in a large community-dwelling sample of older adults, we found no effects of APOE epsilon or TOMM40 523 genotypes on hippocampal volumes. PMID: 24260406
    35. The results of this study suggested that Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms. PMID: 24103330
    36. Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery. PMID: 24149440
    37. This study associating theTOMM40rs10524523 genotype with clinical characteristics ofpatients carrying thePSEN1M146L mutation belong-ing to the same kindred. PMID: 23792692
    38. TOMM40 intron 6 poly-T length may explain some of the variation in age at onset in PSEN2 familial mouseclick Alzheimer's disease PMID: 23183136
    39. These data provide no evidence to support an association of rs2075650 in TOMM40 with neovascular age-related macular degeneration or polypoidal choroidal vasculopathy. PMID: 24146538
    40. This study demonstrated that the TOMM40 gene does not have an APOE-independent role in the risk of developing LOAD and FTLD. PMID: 23546992
    41. 3 SNPs (rs157580, rs2075650, and rs11556505)were studied in late-onset Alzheimer disease after adjustment for risk factors. Haplotypes derived from SNPs in rs2075650, rs11556505, and rs1160985 were associated with either risk or protective effects. PMID: 23288655
    42. the interaction of alpha-Syn with the mitochondrial protein import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity. PMID: 23626796
    43. TOMM40 and APOE common genetic variants are not Parkinson's disease risk factors. PMID: 23522842
    44. TOMM40 gene expression remains significantly lower in Alzheimer's disease patients compared to controls. PMID: 23234877
    45. we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) showing that chronic family stress moderates the association between TOMM40 SNP rs157580 and triglyceride levels. PMID: 23435269
    46. Three SNPs of TOMM40 and APOC1 representating linkage disequilibrium at the 19q13-q13.2 chromosomal region suggest the presence of a different genetic background underlying primary progressive aphasia and the behavioral variant of frontotemporal dementia. PMID: 22710912
    47. Expression levels of TOMM40 protein in mitochondria do not reveal any differences related to the very long or short poly-T variant associated with the risk of late onset Alzheimer's disease. PMID: 22596268
    48. Both TOMM40 and APOE significantly influence age-related memory performance, but they appear to do so independently of each other PMID: 23102119
    49. The results of this study suggested important APOE-independent associations between the TOMM40 '523' polymorphism and specific cognitive domains of memory and executive control that are preferentially affected in early-stage Alzheimer's disease. PMID: 22863908
    50. In chronic hepatitis C, genetic heterogeneity in the APOE/TOMM40 genomic region is significantly associated with variation in serum ApoE and ApoB levels, and also with fibrosis suggesting a pleiotropic attribute of this genomic region. PMID: 22898894

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Tom40 family
  • 數據庫鏈接:

    HGNC: 18001

    OMIM: 608061

    KEGG: hsa:10452

    STRING: 9606.ENSP00000252487

    UniGene: Hs.655909



主站蜘蛛池模板: 午夜成人亚洲理伦片在线观看 | 国产精品久久毛片| 一本色道久久综合亚洲精品| 久久精品夜色噜噜亚洲a∨| 少妇饥渴偷公乱av在线观看涩爱| 无码精品人妻一区二区三区98| 东北妇女xx做爰视频| 午夜成人理论无码电影在线播放| 丰满岳乱妇在线观看中字无码| 亚洲精品久久久久久婷婷| 亚洲精品久久久久久久久久久捆绑 | av小次郎收藏| 曰韩内射六十七十老熟女影视| 国产精品久久久久久妇女| 亚洲综合小说专区图片| 13小箩利洗澡无码视频网站| 浪潮av激情高潮国产精品| 狠狠狠狼鲁亚洲综合网| 麻豆自媒体 一区 二区| 日本边添边摸边做边爱边 | 国产成人啪精品视频网站午夜| 特级做a爰片毛片免费看无码| 双腿张开被9个黑人调教影片 | 醉酒后少妇被疯狂内射视频| 国产成人欧美日韩在线电影| 久久精品人妻无码专区| 亚洲精品久久久中文字幕痴女| 亚洲337少妇裸体艺术| 男人和女人高潮做爰视频| 综合图区亚洲欧美另类图片| 无码av波多野结衣| 午夜a理论片在线播放| 99久热国产精品视频尤物| 一区二区三区在线 | 欧洲| а√中文在线资源库| 中文字幕av一区乱码| 99精品无人区乱码1区2区3区| 国产欠欠欠18一区二区| av天堂永久资源网亚洲高清| 蜜臀av片在线观看| 日本爽爽爽爽爽爽在线观看免|