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TOM1 Antibody

  • 中文名稱:
    TOM1兔多克隆抗體
  • 貨號:
    CSB-PA024043GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TOM1
  • 別名:
    TOM1 antibody; Target of Myb protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TOM1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be involved in intracellular trafficking. Probable association with membranes.
  • 基因功能參考文獻:
    1. This study demonstrated that Tom1 is localized in dystrophic neurites of brain in patient with Alzheimer's disease. PMID: 27206884
    2. Tom1 modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism. PMID: 26320582
    3. candidate multiple myeloma risk locus PMID: 26007630
    4. phosphatidylinositol 5-monophosphate (PI5P) enrichment in signaling endosomes prevents endosomal maturation through the recruitment of TOM1, and point to a new function of PI5P in regulating discrete maturation steps in the endosomal system. PMID: 25588840
    5. It was shown that that myosin VI, in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI binding partner on endosomes. PMID: 23023224
    6. TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis lung. PMID: 20083669
    7. a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin PMID: 14563850
    8. marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
    9. Tollip and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins PMID: 15047686
    10. The results suggest that TOM1 is an important molecule for membrane recruitment of clathrin, and that endofin is able to exploit this recruitment at the endosome. PMID: 15657082
    11. A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage PMID: 17671966

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  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    TOM1 family
  • 組織特異性:
    Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver.
  • 數據庫鏈接:

    HGNC: 11982

    OMIM: 604700

    KEGG: hsa:10043

    STRING: 9606.ENSP00000413697

    UniGene: Hs.474705



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