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  4. TNP1 Antibody, Biotin conjugated

TNP1 Antibody, Biotin conjugated

  • 中文名稱：
    TNP1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA024018LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TNP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TNP1
  • 別名：
    Spermatid nuclear transition protein 1 antibody; Spermatid nuclear transition protein1 antibody; STP 1 antibody; STP-1 antibody; STP1 antibody; STP1_HUMAN antibody; TNP 1 antibody; TNP1 antibody; TP 1 antibody; TP-1 antibody; TP1 antibody; Transition protein 1 (during histone to protamine replacement) antibody; Transition protein1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Spermatid nuclear transition protein 1 protein (12-50AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
  • 基因功能參考文獻：
    1. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively. PMID: 26098692
    2. frequency of the haplotype GCG (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level. PMID: 20522125
    3. a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility PMID: 16291974
    4. We found significantly lower levels of HILS1, TNP1, and TNP2 transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men. PMID: 17852044
    5. The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos. PMID: 18292840
    6. The presence of transition proteins (TP1 and/or TP2) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men. PMID: 18727729

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  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Nuclear transition protein 1 family
  • 組織特異性：
    Expressed by spermatids (at protein level).
  • 數據庫鏈接：

    HGNC: 11951

    OMIM: 190231

    KEGG: hsa:7141

    STRING: 9606.ENSP00000236979

    UniGene: Hs.3017



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